No Cover Image

Journal article 942 views 160 downloads

Sodium Tertiary Pentoxide: A Mild and Efficient Base to Make C-C Bond between Acetylenes and Aldehydes (or) Ketones Producing Propargyl Alcohols

Sebastian Antony Savarimuthu, Hajeeth Thankappan, Selvaraj Augustine Thomas, Devarajan Gnanaprakasi Leo Prakash, Leo Prakash Orcid Logo

ChemistrySelect, Volume: 3, Issue: 29, Pages: 8479 - 8482

Swansea University Author: Leo Prakash Orcid Logo

Check full text

DOI (Published version): 10.1002/slct.201801640

Abstract

This report confirms that sodium tertiary‐pentoxide is a very effective base for the nucleophilic addition of acetylenes to aldehydes and ketones in 1,4‐dioxane at room temperature. These mild and operationally simple procedures have been working well with a variety of aromatic and heteroaromatic al...

Full description

Published in: ChemistrySelect
ISSN: 2365-6549
Published: 2018
Online Access: Check full text

URI: https://cronfa.swan.ac.uk/Record/cronfa43524
Tags: Add Tag
No Tags, Be the first to tag this record!
first_indexed 2018-08-20T13:53:38Z
last_indexed 2018-11-12T20:19:19Z
id cronfa43524
recordtype SURis
fullrecord <?xml version="1.0"?><rfc1807><datestamp>2018-11-12T15:43:18.0725822</datestamp><bib-version>v2</bib-version><id>43524</id><entry>2018-08-20</entry><title>Sodium Tertiary Pentoxide: A Mild and Efficient Base to Make C-C Bond between Acetylenes and Aldehydes (or) Ketones Producing Propargyl Alcohols</title><swanseaauthors><author><sid>bd72868c48af6c0b04bf9f6bb48ce324</sid><ORCID>0000-0002-8812-8927</ORCID><firstname>Leo</firstname><surname>Prakash</surname><name>Leo Prakash</name><active>true</active><ethesisStudent>false</ethesisStudent></author></swanseaauthors><date>2018-08-20</date><deptcode>MTLS</deptcode><abstract>This report confirms that sodium tertiary&#x2010;pentoxide is a very effective base for the nucleophilic addition of acetylenes to aldehydes and ketones in 1,4&#x2010;dioxane at room temperature. These mild and operationally simple procedures have been working well with a variety of aromatic and heteroaromatic aldehydes and also equally working well with aliphatic, aromatic and heteroaromatic ketones. A very clean product of secondary and tertiary propargylic alcohols were obtained from 70&#x2013;94% yield. This process has been explored in bulk scale synthesis on selected molecules and also adapted the column free purification for most of the substrates.</abstract><type>Journal Article</type><journal>ChemistrySelect</journal><volume>3</volume><journalNumber>29</journalNumber><paginationStart>8479</paginationStart><paginationEnd>8482</paginationEnd><publisher/><issnPrint>2365-6549</issnPrint><keywords>Aldehydes, Alkynes, C&#x2013;C bond formation Ketones, Propargyl alcohols</keywords><publishedDay>31</publishedDay><publishedMonth>12</publishedMonth><publishedYear>2018</publishedYear><publishedDate>2018-12-31</publishedDate><doi>10.1002/slct.201801640</doi><url/><notes/><college>COLLEGE NANME</college><department>Materials Science and Engineering</department><CollegeCode>COLLEGE CODE</CollegeCode><DepartmentCode>MTLS</DepartmentCode><institution>Swansea University</institution><apcterm/><lastEdited>2018-11-12T15:43:18.0725822</lastEdited><Created>2018-08-20T09:43:50.1151246</Created><path><level id="1">Faculty of Science and Engineering</level><level id="2">School of Engineering and Applied Sciences - Materials Science and Engineering</level></path><authors><author><firstname>Sebastian Antony</firstname><surname>Savarimuthu</surname><order>1</order></author><author><firstname>Hajeeth</firstname><surname>Thankappan</surname><order>2</order></author><author><firstname>Selvaraj Augustine</firstname><surname>Thomas</surname><order>3</order></author><author><firstname>Devarajan Gnanaprakasi Leo</firstname><surname>Prakash</surname><order>4</order></author><author><firstname>Leo</firstname><surname>Prakash</surname><orcid>0000-0002-8812-8927</orcid><order>5</order></author></authors><documents><document><filename>0043524-18092018091017.pdf</filename><originalFilename>savarimuthu2018.pdf</originalFilename><uploaded>2018-09-18T09:10:17.6430000</uploaded><type>Output</type><contentLength>499007</contentLength><contentType>application/pdf</contentType><version>Accepted Manuscript</version><cronfaStatus>true</cronfaStatus><embargoDate>2019-08-02T00:00:00.0000000</embargoDate><copyrightCorrect>true</copyrightCorrect><language>eng</language></document></documents><OutputDurs/></rfc1807>
spelling 2018-11-12T15:43:18.0725822 v2 43524 2018-08-20 Sodium Tertiary Pentoxide: A Mild and Efficient Base to Make C-C Bond between Acetylenes and Aldehydes (or) Ketones Producing Propargyl Alcohols bd72868c48af6c0b04bf9f6bb48ce324 0000-0002-8812-8927 Leo Prakash Leo Prakash true false 2018-08-20 MTLS This report confirms that sodium tertiary‐pentoxide is a very effective base for the nucleophilic addition of acetylenes to aldehydes and ketones in 1,4‐dioxane at room temperature. These mild and operationally simple procedures have been working well with a variety of aromatic and heteroaromatic aldehydes and also equally working well with aliphatic, aromatic and heteroaromatic ketones. A very clean product of secondary and tertiary propargylic alcohols were obtained from 70–94% yield. This process has been explored in bulk scale synthesis on selected molecules and also adapted the column free purification for most of the substrates. Journal Article ChemistrySelect 3 29 8479 8482 2365-6549 Aldehydes, Alkynes, C–C bond formation Ketones, Propargyl alcohols 31 12 2018 2018-12-31 10.1002/slct.201801640 COLLEGE NANME Materials Science and Engineering COLLEGE CODE MTLS Swansea University 2018-11-12T15:43:18.0725822 2018-08-20T09:43:50.1151246 Faculty of Science and Engineering School of Engineering and Applied Sciences - Materials Science and Engineering Sebastian Antony Savarimuthu 1 Hajeeth Thankappan 2 Selvaraj Augustine Thomas 3 Devarajan Gnanaprakasi Leo Prakash 4 Leo Prakash 0000-0002-8812-8927 5 0043524-18092018091017.pdf savarimuthu2018.pdf 2018-09-18T09:10:17.6430000 Output 499007 application/pdf Accepted Manuscript true 2019-08-02T00:00:00.0000000 true eng
title Sodium Tertiary Pentoxide: A Mild and Efficient Base to Make C-C Bond between Acetylenes and Aldehydes (or) Ketones Producing Propargyl Alcohols
spellingShingle Sodium Tertiary Pentoxide: A Mild and Efficient Base to Make C-C Bond between Acetylenes and Aldehydes (or) Ketones Producing Propargyl Alcohols
Leo Prakash
title_short Sodium Tertiary Pentoxide: A Mild and Efficient Base to Make C-C Bond between Acetylenes and Aldehydes (or) Ketones Producing Propargyl Alcohols
title_full Sodium Tertiary Pentoxide: A Mild and Efficient Base to Make C-C Bond between Acetylenes and Aldehydes (or) Ketones Producing Propargyl Alcohols
title_fullStr Sodium Tertiary Pentoxide: A Mild and Efficient Base to Make C-C Bond between Acetylenes and Aldehydes (or) Ketones Producing Propargyl Alcohols
title_full_unstemmed Sodium Tertiary Pentoxide: A Mild and Efficient Base to Make C-C Bond between Acetylenes and Aldehydes (or) Ketones Producing Propargyl Alcohols
title_sort Sodium Tertiary Pentoxide: A Mild and Efficient Base to Make C-C Bond between Acetylenes and Aldehydes (or) Ketones Producing Propargyl Alcohols
author_id_str_mv bd72868c48af6c0b04bf9f6bb48ce324
author_id_fullname_str_mv bd72868c48af6c0b04bf9f6bb48ce324_***_Leo Prakash
author Leo Prakash
author2 Sebastian Antony Savarimuthu
Hajeeth Thankappan
Selvaraj Augustine Thomas
Devarajan Gnanaprakasi Leo Prakash
Leo Prakash
format Journal article
container_title ChemistrySelect
container_volume 3
container_issue 29
container_start_page 8479
publishDate 2018
institution Swansea University
issn 2365-6549
doi_str_mv 10.1002/slct.201801640
college_str Faculty of Science and Engineering
hierarchytype
hierarchy_top_id facultyofscienceandengineering
hierarchy_top_title Faculty of Science and Engineering
hierarchy_parent_id facultyofscienceandengineering
hierarchy_parent_title Faculty of Science and Engineering
department_str School of Engineering and Applied Sciences - Materials Science and Engineering{{{_:::_}}}Faculty of Science and Engineering{{{_:::_}}}School of Engineering and Applied Sciences - Materials Science and Engineering
document_store_str 1
active_str 0
description This report confirms that sodium tertiary‐pentoxide is a very effective base for the nucleophilic addition of acetylenes to aldehydes and ketones in 1,4‐dioxane at room temperature. These mild and operationally simple procedures have been working well with a variety of aromatic and heteroaromatic aldehydes and also equally working well with aliphatic, aromatic and heteroaromatic ketones. A very clean product of secondary and tertiary propargylic alcohols were obtained from 70–94% yield. This process has been explored in bulk scale synthesis on selected molecules and also adapted the column free purification for most of the substrates.
published_date 2018-12-31T03:54:44Z
_version_ 1763752735951290368
score 11.016235

Similar Items