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Atomistic–continuum model for probing the biomechanical properties of human erythrocyte membrane under extreme conditions

Adesola Ademiloye Orcid Logo, L.W. Zhang, K.M. Liew

Computer Methods in Applied Mechanics and Engineering, Volume: 325, Pages: 22 - 36

Swansea University Author: Adesola Ademiloye Orcid Logo

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Abstract

A precise first attempt is performed to quantify the biomechanical properties of human erythrocyte membrane subjects to extreme temperature and loading conditions. An improved three-dimensional (3D) atomistic–continuum model based on the Cauchy–Born rule is proposed to investigate the elastic proper...

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Published in: Computer Methods in Applied Mechanics and Engineering
ISSN: 0045-7825
Published: Elsevier BV 2017
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URI: https://cronfa.swan.ac.uk/Record/cronfa44905
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Abstract: A precise first attempt is performed to quantify the biomechanical properties of human erythrocyte membrane subjects to extreme temperature and loading conditions. An improved three-dimensional (3D) atomistic–continuum model based on the Cauchy–Born rule is proposed to investigate the elastic properties and biomechanical responses of the erythrocyte membrane. A membrane rigidity model is developed to estimate the membrane elastic properties over an extreme temperature range. Our computational results reveal that the membrane is able to sustain large strains up to a certain limit; beyond which, mechanically induced hemolysis may occur as exponential stress increment, fluctuations and multiple peaks were observed in the stress–strain curves. Additionally, we found that the overall deformability of the erythrocyte membrane significantly decreases as temperature increases. It is concluded that the observed increase in membrane rigidity may be attributed to the denaturation, structural remodeling and cross-linking of membrane cytoskeletal proteins.
Keywords: Erythrocyte membrane deformability, Large strains and deformation, Multiscale Cauchy–Born framework, Elastic properties, Temperature effect
College: College of Engineering
Start Page: 22
End Page: 36