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Atomistic–continuum model for probing the biomechanical properties of human erythrocyte membrane under extreme conditions

Adesola Ademiloye Orcid Logo, L.W. Zhang, K.M. Liew

Computer Methods in Applied Mechanics and Engineering, Volume: 325, Pages: 22 - 36

Swansea University Author: Adesola Ademiloye Orcid Logo

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DOI (Published version): 10.1016/j.cma.2017.06.033

Abstract

A precise first attempt is performed to quantify the biomechanical properties of human erythrocyte membrane subjects to extreme temperature and loading conditions. An improved three-dimensional (3D) atomistic–continuum model based on the Cauchy–Born rule is proposed to investigate the elastic proper...

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Published in: Computer Methods in Applied Mechanics and Engineering
ISSN: 0045-7825
Published: Elsevier BV 2017
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URI: https://cronfa.swan.ac.uk/Record/cronfa44905
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first_indexed 2018-10-16T13:47:48Z
last_indexed 2018-11-16T20:16:12Z
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spelling 2018-11-16T13:45:32.3882822 v2 44905 2018-10-16 Atomistic–continuum model for probing the biomechanical properties of human erythrocyte membrane under extreme conditions e37960ed89a7e3eaeba2201762626594 0000-0002-9741-6488 Adesola Ademiloye Adesola Ademiloye true false 2018-10-16 MEDE A precise first attempt is performed to quantify the biomechanical properties of human erythrocyte membrane subjects to extreme temperature and loading conditions. An improved three-dimensional (3D) atomistic–continuum model based on the Cauchy–Born rule is proposed to investigate the elastic properties and biomechanical responses of the erythrocyte membrane. A membrane rigidity model is developed to estimate the membrane elastic properties over an extreme temperature range. Our computational results reveal that the membrane is able to sustain large strains up to a certain limit; beyond which, mechanically induced hemolysis may occur as exponential stress increment, fluctuations and multiple peaks were observed in the stress–strain curves. Additionally, we found that the overall deformability of the erythrocyte membrane significantly decreases as temperature increases. It is concluded that the observed increase in membrane rigidity may be attributed to the denaturation, structural remodeling and cross-linking of membrane cytoskeletal proteins. Journal Article Computer Methods in Applied Mechanics and Engineering 325 22 36 Elsevier BV 0045-7825 Erythrocyte membrane deformability, Large strains and deformation, Multiscale Cauchy–Born framework, Elastic properties, Temperature effect 31 10 2017 2017-10-31 10.1016/j.cma.2017.06.033 COLLEGE NANME Biomedical Engineering COLLEGE CODE MEDE Swansea University 2018-11-16T13:45:32.3882822 2018-10-16T12:47:43.0137916 Faculty of Science and Engineering School of Engineering and Applied Sciences - Biomedical Engineering Adesola Ademiloye 0000-0002-9741-6488 1 L.W. Zhang 2 K.M. Liew 3
title Atomistic–continuum model for probing the biomechanical properties of human erythrocyte membrane under extreme conditions
spellingShingle Atomistic–continuum model for probing the biomechanical properties of human erythrocyte membrane under extreme conditions
Adesola Ademiloye
title_short Atomistic–continuum model for probing the biomechanical properties of human erythrocyte membrane under extreme conditions
title_full Atomistic–continuum model for probing the biomechanical properties of human erythrocyte membrane under extreme conditions
title_fullStr Atomistic–continuum model for probing the biomechanical properties of human erythrocyte membrane under extreme conditions
title_full_unstemmed Atomistic–continuum model for probing the biomechanical properties of human erythrocyte membrane under extreme conditions
title_sort Atomistic–continuum model for probing the biomechanical properties of human erythrocyte membrane under extreme conditions
author_id_str_mv e37960ed89a7e3eaeba2201762626594
author_id_fullname_str_mv e37960ed89a7e3eaeba2201762626594_***_Adesola Ademiloye
author Adesola Ademiloye
author2 Adesola Ademiloye
L.W. Zhang
K.M. Liew
format Journal article
container_title Computer Methods in Applied Mechanics and Engineering
container_volume 325
container_start_page 22
publishDate 2017
institution Swansea University
issn 0045-7825
doi_str_mv 10.1016/j.cma.2017.06.033
publisher Elsevier BV
college_str Faculty of Science and Engineering
hierarchytype
hierarchy_top_id facultyofscienceandengineering
hierarchy_top_title Faculty of Science and Engineering
hierarchy_parent_id facultyofscienceandengineering
hierarchy_parent_title Faculty of Science and Engineering
department_str School of Engineering and Applied Sciences - Biomedical Engineering{{{_:::_}}}Faculty of Science and Engineering{{{_:::_}}}School of Engineering and Applied Sciences - Biomedical Engineering
document_store_str 0
active_str 0
description A precise first attempt is performed to quantify the biomechanical properties of human erythrocyte membrane subjects to extreme temperature and loading conditions. An improved three-dimensional (3D) atomistic–continuum model based on the Cauchy–Born rule is proposed to investigate the elastic properties and biomechanical responses of the erythrocyte membrane. A membrane rigidity model is developed to estimate the membrane elastic properties over an extreme temperature range. Our computational results reveal that the membrane is able to sustain large strains up to a certain limit; beyond which, mechanically induced hemolysis may occur as exponential stress increment, fluctuations and multiple peaks were observed in the stress–strain curves. Additionally, we found that the overall deformability of the erythrocyte membrane significantly decreases as temperature increases. It is concluded that the observed increase in membrane rigidity may be attributed to the denaturation, structural remodeling and cross-linking of membrane cytoskeletal proteins.
published_date 2017-10-31T03:56:23Z
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score 11.016235

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