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A multiscale Cauchy–Born meshfree model for deformability of red blood cells parasitized by Plasmodium falciparum

L.W. Zhang, Adesola Ademiloye Orcid Logo, K.M. Liew

Journal of the Mechanics and Physics of Solids, Volume: 101, Pages: 268 - 284

Swansea University Author: Adesola Ademiloye Orcid Logo

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Abstract

In normal physiological and healthy conditions, red blood cells (RBCs) deform readily as they pass through the microcapillaries and the spleen, however, upon invasion by the malaria parasite, the host RBC membrane begins to lose their deformability. In spite of the progress in understanding malaria...

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Published in: Journal of the Mechanics and Physics of Solids
ISSN: 0022-5096
Published: Elsevier BV 2017
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URI: https://cronfa.swan.ac.uk/Record/cronfa44910
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spelling 2020-07-01T16:29:58.9736133 v2 44910 2018-10-16 A multiscale Cauchy–Born meshfree model for deformability of red blood cells parasitized by Plasmodium falciparum e37960ed89a7e3eaeba2201762626594 0000-0002-9741-6488 Adesola Ademiloye Adesola Ademiloye true false 2018-10-16 MEDE In normal physiological and healthy conditions, red blood cells (RBCs) deform readily as they pass through the microcapillaries and the spleen, however, upon invasion by the malaria parasite, the host RBC membrane begins to lose their deformability. In spite of the progress in understanding malaria pathogenesis, the primary mechanism responsible for the loss of deformability remains unclear. In this paper, we examine the effects of Plasmodium falciparum infection and maturation on the deformability of parasitized or infected red blood cells (iRBCs) by means of a three-dimensional (3D) multiscale red blood cell (RBC) framework. This multiscale framework is developed based on the Cauchy–Born rule and the meshfree IMLS-Ritz method. The atomistic scale strain energy density function of the RBC membrane was computed using a selected representative cell based on the membrane spectrin network. The results obtained from our numerical simulations affirm that the presence of malaria infection significantly increases the rigidity of RBC membrane. It was observed that in the trophozoite and schizont infection stages, biconcave cell geometry leads to better prediction than nearly spherical geometry in comparison with experimental studies. Furthermore, we confirm that increase in temperature also results to increased stiffening of the cell membrane. Lastly, the observed decrease in the deformability of iRBC membrane may be primarily due to the structural remodeling and changes in the microstructure of the membrane rather than the change in cell shape. Journal Article Journal of the Mechanics and Physics of Solids 101 268 284 Elsevier BV 0022-5096 Multiscale modeling, Meshfree IMLS-Ritz method, Cauchy-Born rule, Red blood cells, Large deformation, Plasmodium falciparum 31 1 2017 2017-01-31 10.1016/j.jmps.2017.01.009 COLLEGE NANME Biomedical Engineering COLLEGE CODE MEDE Swansea University 2020-07-01T16:29:58.9736133 2018-10-16T12:47:49.9758477 College of Engineering Engineering L.W. Zhang 1 Adesola Ademiloye 0000-0002-9741-6488 2 K.M. Liew 3
title A multiscale Cauchy–Born meshfree model for deformability of red blood cells parasitized by Plasmodium falciparum
spellingShingle A multiscale Cauchy–Born meshfree model for deformability of red blood cells parasitized by Plasmodium falciparum
Adesola Ademiloye
title_short A multiscale Cauchy–Born meshfree model for deformability of red blood cells parasitized by Plasmodium falciparum
title_full A multiscale Cauchy–Born meshfree model for deformability of red blood cells parasitized by Plasmodium falciparum
title_fullStr A multiscale Cauchy–Born meshfree model for deformability of red blood cells parasitized by Plasmodium falciparum
title_full_unstemmed A multiscale Cauchy–Born meshfree model for deformability of red blood cells parasitized by Plasmodium falciparum
title_sort A multiscale Cauchy–Born meshfree model for deformability of red blood cells parasitized by Plasmodium falciparum
author_id_str_mv e37960ed89a7e3eaeba2201762626594
author_id_fullname_str_mv e37960ed89a7e3eaeba2201762626594_***_Adesola Ademiloye
author Adesola Ademiloye
author2 L.W. Zhang
Adesola Ademiloye
K.M. Liew
format Journal article
container_title Journal of the Mechanics and Physics of Solids
container_volume 101
container_start_page 268
publishDate 2017
institution Swansea University
issn 0022-5096
doi_str_mv 10.1016/j.jmps.2017.01.009
publisher Elsevier BV
college_str College of Engineering
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hierarchy_top_title College of Engineering
hierarchy_parent_id collegeofengineering
hierarchy_parent_title College of Engineering
department_str Engineering{{{_:::_}}}College of Engineering{{{_:::_}}}Engineering
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description In normal physiological and healthy conditions, red blood cells (RBCs) deform readily as they pass through the microcapillaries and the spleen, however, upon invasion by the malaria parasite, the host RBC membrane begins to lose their deformability. In spite of the progress in understanding malaria pathogenesis, the primary mechanism responsible for the loss of deformability remains unclear. In this paper, we examine the effects of Plasmodium falciparum infection and maturation on the deformability of parasitized or infected red blood cells (iRBCs) by means of a three-dimensional (3D) multiscale red blood cell (RBC) framework. This multiscale framework is developed based on the Cauchy–Born rule and the meshfree IMLS-Ritz method. The atomistic scale strain energy density function of the RBC membrane was computed using a selected representative cell based on the membrane spectrin network. The results obtained from our numerical simulations affirm that the presence of malaria infection significantly increases the rigidity of RBC membrane. It was observed that in the trophozoite and schizont infection stages, biconcave cell geometry leads to better prediction than nearly spherical geometry in comparison with experimental studies. Furthermore, we confirm that increase in temperature also results to increased stiffening of the cell membrane. Lastly, the observed decrease in the deformability of iRBC membrane may be primarily due to the structural remodeling and changes in the microstructure of the membrane rather than the change in cell shape.
published_date 2017-01-31T03:59:02Z
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score 10.897445