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Transport of solid bodies along tubular membrane tethers / D. R. Daniels

PLOS ONE, Volume: 14, Issue: 1, Start page: e0210259

Swansea University Author: Daniels, Rob

Abstract

We study the crucial role of membrane fluctuations in maintaining a narrow gap between a fluid membrane tube and an enclosed solid particle. Solvent flows can occur in this gap, hence giving rise to a finite particle mobility along the tube. While our study has relevance for how cells are able to tr...

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Published in: PLOS ONE
ISSN: 1932-6203
Published: 2019
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URI: https://cronfa.swan.ac.uk/Record/cronfa48060
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spelling 2019-07-29T14:31:37Z v2 48060 2019-01-07 Transport of solid bodies along tubular membrane tethers Rob Daniels Rob Daniels true 0000-0002-6933-8144 false 23f38c3bb732d4378986bdfaf7b6ee51 7e4849761d1281b734572d8eaf34c9e1 XqkHHGKcvrejwE3vm2Nc5hXCE6Z9OGBXOD9D5JU4+T4= 2019-01-07 EEN We study the crucial role of membrane fluctuations in maintaining a narrow gap between a fluid membrane tube and an enclosed solid particle. Solvent flows can occur in this gap, hence giving rise to a finite particle mobility along the tube. While our study has relevance for how cells are able to transport large organelles or other cargo along connecting membrane tubes, known as tunneling nanotubes, our calculations are also framed so that they can be tested by a specific in vitro experiment: A tubular membrane tether can be pulled from a membrane reservoir, such as an aspirated Giant Unilamellar Vesicle (GUV), e.g. using a conjugated bead that binds to the membrane and is held in a laser trap. We compute the subsequent mobility of colloidal particles trapped in the tube, focusing on the case when the particle is large compared to the equilibrium tube radius. We predict that the particle mobility should scale as ∼ σ−2/3, with σ the membrane tension. Journal article PLOS ONE 14 1 e0210259 1932-6203 16 1 2019 2019-01-16 10.1371/journal.pone.0210259 College of Engineering Engineering CENG EEN Multidisciplinary Nanotechnology Centre None 2019-07-29T14:31:37Z 2019-01-07T14:10:25Z College of Engineering Engineering D. R. Daniels 1 0048060-18012019151308.pdf daniels2019.pdf 2019-01-18T15:13:08Z Output 4126326 application/pdf VoR true Updated Copyright 11/03/2019 2019-01-18T00:00:00 true eng
title Transport of solid bodies along tubular membrane tethers
spellingShingle Transport of solid bodies along tubular membrane tethers
Daniels, Rob
title_short Transport of solid bodies along tubular membrane tethers
title_full Transport of solid bodies along tubular membrane tethers
title_fullStr Transport of solid bodies along tubular membrane tethers
title_full_unstemmed Transport of solid bodies along tubular membrane tethers
title_sort Transport of solid bodies along tubular membrane tethers
author_id_str_mv 23f38c3bb732d4378986bdfaf7b6ee51
author_id_fullname_str_mv 23f38c3bb732d4378986bdfaf7b6ee51_***_Daniels, Rob
author Daniels, Rob
author2 D. R. Daniels
format Journal article
container_title PLOS ONE
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institution Swansea University
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doi_str_mv 10.1371/journal.pone.0210259
college_str College of Engineering
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hierarchy_parent_title College of Engineering
department_str Engineering{{{_:::_}}}College of Engineering{{{_:::_}}}Engineering
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researchgroup_str Multidisciplinary Nanotechnology Centre
description We study the crucial role of membrane fluctuations in maintaining a narrow gap between a fluid membrane tube and an enclosed solid particle. Solvent flows can occur in this gap, hence giving rise to a finite particle mobility along the tube. While our study has relevance for how cells are able to transport large organelles or other cargo along connecting membrane tubes, known as tunneling nanotubes, our calculations are also framed so that they can be tested by a specific in vitro experiment: A tubular membrane tether can be pulled from a membrane reservoir, such as an aspirated Giant Unilamellar Vesicle (GUV), e.g. using a conjugated bead that binds to the membrane and is held in a laser trap. We compute the subsequent mobility of colloidal particles trapped in the tube, focusing on the case when the particle is large compared to the equilibrium tube radius. We predict that the particle mobility should scale as ∼ σ−2/3, with σ the membrane tension.
published_date 2019-01-16T08:26:54Z
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