Journal article 518 views 97 downloads
Oxysterol research: a brief review
,
Yuqin Wang
Biochemical Society Transactions, Volume: 47, Issue: 2, Pages: 517 - 526
Swansea University Author:
William Griffiths
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DOI (Published version): 10.1042/BST20180135
Abstract
In this article we discuss the recent developments in oxysterol research. Exciting results have been reported relating to the involvement of oxysterols in the fields of neurodegenerative disease, especially in Huntington’s disease, Parkinson’s disease and Alzheimer’s disease; in signalling and devel...
| Published in: | Biochemical Society Transactions |
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| ISSN: | 0300-5127 1470-8752 |
| Published: |
Portland Press
2019
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| Online Access: |
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| URI: | https://cronfa.swan.ac.uk/Record/cronfa49840 |
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| Abstract: |
In this article we discuss the recent developments in oxysterol research. Exciting results have been reported relating to the involvement of oxysterols in the fields of neurodegenerative disease, especially in Huntington’s disease, Parkinson’s disease and Alzheimer’s disease; in signalling and development, in particular in relation to Hedgehog signalling; and in cancer, with special focus on (25R)26-hydroxycholesterol. Methods for the measurement of oxysterols, essential for understanding their mechanism of action in vivo, and valuable for diagnosing rare diseases of cholesterol biosynthesis and metabolism are briefly considered. |
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| College: |
Faculty of Medicine, Health and Life Sciences |
| Issue: |
2 |
| Start Page: |
517 |
| End Page: |
526 |