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Oxysterol research: a brief review / William J. Griffiths; Yuqin Wang

Biochemical Society Transactions, Start page: BST20180135

Swansea University Author: Griffiths, William

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DOI (Published version): 10.1042/BST20180135

Abstract

In this article we discuss the recent developments in oxysterol research. Exciting results have been reported relating to the involvement of oxysterols in the fields of neurodegenerative disease, especially in Huntington’s disease, Parkinson’s disease and Alzheimer’s disease; in signalling and devel...

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Published in: Biochemical Society Transactions
ISSN: 0300-5127 1470-8752
Published: Portland Press 2019
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URI: https://cronfa.swan.ac.uk/Record/cronfa49840
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Abstract: In this article we discuss the recent developments in oxysterol research. Exciting results have been reported relating to the involvement of oxysterols in the fields of neurodegenerative disease, especially in Huntington’s disease, Parkinson’s disease and Alzheimer’s disease; in signalling and development, in particular in relation to Hedgehog signalling; and in cancer, with special focus on (25R)26-hydroxycholesterol. Methods for the measurement of oxysterols, essential for understanding their mechanism of action in vivo, and valuable for diagnosing rare diseases of cholesterol biosynthesis and metabolism are briefly considered.
College: Swansea University Medical School
Start Page: BST20180135