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Oxysterol research: a brief review / William Griffiths, Yuqin Wang

Biochemical Society Transactions, Volume: 47, Issue: 2, Pages: 517 - 526

Swansea University Author: William Griffiths

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DOI (Published version): 10.1042/BST20180135

Abstract

In this article we discuss the recent developments in oxysterol research. Exciting results have been reported relating to the involvement of oxysterols in the fields of neurodegenerative disease, especially in Huntington’s disease, Parkinson’s disease and Alzheimer’s disease; in signalling and devel...

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Published in: Biochemical Society Transactions
ISSN: 0300-5127 1470-8752
Published: Portland Press 2019
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URI: https://cronfa.swan.ac.uk/Record/cronfa49840
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first_indexed 2019-04-02T10:19:33Z
last_indexed 2019-06-05T11:05:36Z
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spelling 2019-05-24T19:08:30.9635932 v2 49840 2019-04-01 Oxysterol research: a brief review 3316b1d1b524be1831790933eed1c26e 0000-0002-4129-6616 William Griffiths William Griffiths true false 2019-04-01 BMS In this article we discuss the recent developments in oxysterol research. Exciting results have been reported relating to the involvement of oxysterols in the fields of neurodegenerative disease, especially in Huntington’s disease, Parkinson’s disease and Alzheimer’s disease; in signalling and development, in particular in relation to Hedgehog signalling; and in cancer, with special focus on (25R)26-hydroxycholesterol. Methods for the measurement of oxysterols, essential for understanding their mechanism of action in vivo, and valuable for diagnosing rare diseases of cholesterol biosynthesis and metabolism are briefly considered. Journal Article Biochemical Society Transactions 47 2 517 526 Portland Press 0300-5127 1470-8752 31 12 2019 2019-12-31 10.1042/BST20180135 COLLEGE NANME Biomedical Sciences COLLEGE CODE BMS Swansea University UKRI, BB/N015932/1 2019-05-24T19:08:30.9635932 2019-04-01T11:59:03.4579208 Swansea University Medical School Medicine William Griffiths 0000-0002-4129-6616 1 Yuqin Wang 2 0049840-04042019084822.pdf BST-2018-0135C_VoR.pdf 2019-04-04T08:48:22.1570000 Output 898716 application/pdf Version of Record true 2019-04-04T00:00:00.0000000 Distributed under the terms of a Creative Commons CC-BY 4.0 Licence. true eng
title Oxysterol research: a brief review
spellingShingle Oxysterol research: a brief review
William, Griffiths
title_short Oxysterol research: a brief review
title_full Oxysterol research: a brief review
title_fullStr Oxysterol research: a brief review
title_full_unstemmed Oxysterol research: a brief review
title_sort Oxysterol research: a brief review
author_id_str_mv 3316b1d1b524be1831790933eed1c26e
author_id_fullname_str_mv 3316b1d1b524be1831790933eed1c26e_***_William, Griffiths
author William, Griffiths
author2 William Griffiths
Yuqin Wang
format Journal article
container_title Biochemical Society Transactions
container_volume 47
container_issue 2
container_start_page 517
publishDate 2019
institution Swansea University
issn 0300-5127
1470-8752
doi_str_mv 10.1042/BST20180135
publisher Portland Press
college_str Swansea University Medical School
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hierarchy_top_id swanseauniversitymedicalschool
hierarchy_top_title Swansea University Medical School
hierarchy_parent_id swanseauniversitymedicalschool
hierarchy_parent_title Swansea University Medical School
department_str Medicine{{{_:::_}}}Swansea University Medical School{{{_:::_}}}Medicine
document_store_str 1
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description In this article we discuss the recent developments in oxysterol research. Exciting results have been reported relating to the involvement of oxysterols in the fields of neurodegenerative disease, especially in Huntington’s disease, Parkinson’s disease and Alzheimer’s disease; in signalling and development, in particular in relation to Hedgehog signalling; and in cancer, with special focus on (25R)26-hydroxycholesterol. Methods for the measurement of oxysterols, essential for understanding their mechanism of action in vivo, and valuable for diagnosing rare diseases of cholesterol biosynthesis and metabolism are briefly considered.
published_date 2019-12-31T04:09:59Z
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