Journal article 692 views
Design, synthesis and biological evaluation of novel vicinal diaryl-substituted 1H-Pyrazole analogues of combretastatin A-4 as highly potent tubulin polymerization inhibitors
Romeo Romagnoli,
Paola Oliva,
Maria Kimatrai Salvador,
Maria Encarnacion Camacho,
Chiara Padroni,
Andrea Brancale,
Salvatore Ferla
,
Ernest Hamel,
Roberto Ronca,
Elisabetta Grillo,
Roberta Bortolozzi,
Fatlum Rruga,
Elena Mariotto,
Giampietro Viola
European Journal of Medicinal Chemistry, Volume: 181, Start page: 111577
Swansea University Author:
Salvatore Ferla
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DOI (Published version): 10.1016/j.ejmech.2019.111577
Abstract
Design, synthesis and biological evaluation of novel vicinal diaryl-substituted 1H-Pyrazole analogues of combretastatin A-4 as highly potent tubulin polymerization inhibitors
Published in: | European Journal of Medicinal Chemistry |
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ISSN: | 0223-5234 |
Published: |
Elsevier BV
2019
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URI: | https://cronfa.swan.ac.uk/Record/cronfa55235 |
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2020-11-06T11:44:27.8921742 v2 55235 2020-09-20 Design, synthesis and biological evaluation of novel vicinal diaryl-substituted 1H-Pyrazole analogues of combretastatin A-4 as highly potent tubulin polymerization inhibitors d4c62248f510e3b221916989a7bbe6a6 0000-0002-5918-9237 Salvatore Ferla Salvatore Ferla true false 2020-09-20 PHAR Journal Article European Journal of Medicinal Chemistry 181 111577 Elsevier BV 0223-5234 Microtubules; Structure-activity relationship; 1H-pyrazole; Antiproliferative activity; Tubulin 1 11 2019 2019-11-01 10.1016/j.ejmech.2019.111577 COLLEGE NANME Pharmacy COLLEGE CODE PHAR Swansea University 2020-11-06T11:44:27.8921742 2020-09-20T14:30:42.9213672 Faculty of Medicine, Health and Life Sciences Swansea University Medical School - Medicine Romeo Romagnoli 1 Paola Oliva 2 Maria Kimatrai Salvador 3 Maria Encarnacion Camacho 4 Chiara Padroni 5 Andrea Brancale 6 Salvatore Ferla 0000-0002-5918-9237 7 Ernest Hamel 8 Roberto Ronca 9 Elisabetta Grillo 10 Roberta Bortolozzi 11 Fatlum Rruga 12 Elena Mariotto 13 Giampietro Viola 14 |
title |
Design, synthesis and biological evaluation of novel vicinal diaryl-substituted 1H-Pyrazole analogues of combretastatin A-4 as highly potent tubulin polymerization inhibitors |
spellingShingle |
Design, synthesis and biological evaluation of novel vicinal diaryl-substituted 1H-Pyrazole analogues of combretastatin A-4 as highly potent tubulin polymerization inhibitors Salvatore Ferla |
title_short |
Design, synthesis and biological evaluation of novel vicinal diaryl-substituted 1H-Pyrazole analogues of combretastatin A-4 as highly potent tubulin polymerization inhibitors |
title_full |
Design, synthesis and biological evaluation of novel vicinal diaryl-substituted 1H-Pyrazole analogues of combretastatin A-4 as highly potent tubulin polymerization inhibitors |
title_fullStr |
Design, synthesis and biological evaluation of novel vicinal diaryl-substituted 1H-Pyrazole analogues of combretastatin A-4 as highly potent tubulin polymerization inhibitors |
title_full_unstemmed |
Design, synthesis and biological evaluation of novel vicinal diaryl-substituted 1H-Pyrazole analogues of combretastatin A-4 as highly potent tubulin polymerization inhibitors |
title_sort |
Design, synthesis and biological evaluation of novel vicinal diaryl-substituted 1H-Pyrazole analogues of combretastatin A-4 as highly potent tubulin polymerization inhibitors |
author_id_str_mv |
d4c62248f510e3b221916989a7bbe6a6 |
author_id_fullname_str_mv |
d4c62248f510e3b221916989a7bbe6a6_***_Salvatore Ferla |
author |
Salvatore Ferla |
author2 |
Romeo Romagnoli Paola Oliva Maria Kimatrai Salvador Maria Encarnacion Camacho Chiara Padroni Andrea Brancale Salvatore Ferla Ernest Hamel Roberto Ronca Elisabetta Grillo Roberta Bortolozzi Fatlum Rruga Elena Mariotto Giampietro Viola |
format |
Journal article |
container_title |
European Journal of Medicinal Chemistry |
container_volume |
181 |
container_start_page |
111577 |
publishDate |
2019 |
institution |
Swansea University |
issn |
0223-5234 |
doi_str_mv |
10.1016/j.ejmech.2019.111577 |
publisher |
Elsevier BV |
college_str |
Faculty of Medicine, Health and Life Sciences |
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facultyofmedicinehealthandlifesciences |
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Faculty of Medicine, Health and Life Sciences |
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facultyofmedicinehealthandlifesciences |
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Faculty of Medicine, Health and Life Sciences |
department_str |
Swansea University Medical School - Medicine{{{_:::_}}}Faculty of Medicine, Health and Life Sciences{{{_:::_}}}Swansea University Medical School - Medicine |
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published_date |
2019-11-01T04:09:18Z |
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1763753652373159936 |
score |
11.021648 |