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Update on LIPID MAPS classification, nomenclature, and shorthand notation for MS-derived lipid structures

Gerhard Liebisch, Eoin Fahy, Junken Aoki, Edward A. Dennis, Thierry Durand, Christer S. Ejsing, Maria Fedorova, Ivo Feussner, William Griffiths Orcid Logo, Harald Köfeler, Alfred H. Merrill, Robert C. Murphy, Valerie B. O’Donnell, Olga Oskolkova, Shankar Subramaniam, Michael J. O. Wakelam, Friedrich Spener

Journal of Lipid Research, Volume: 61, Issue: 12, Pages: 1539 - 1555

Swansea University Author: William Griffiths Orcid Logo

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DOI (Published version): 10.1194/jlr.s120001025

Abstract

A comprehensive and standardized system to report lipid structures analyzed by mass spectrometry is essentialfor the communication and storage of lipidomics data. Herein, an update on both the LIPID MAPSclassification system and shorthand notation of lipid structures is presented for lipid categorie...

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Published in: Journal of Lipid Research
ISSN: 0022-2275 1539-7262
Published: American Society for Biochemistry & Molecular Biology (ASBMB) 2020
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URI: https://cronfa.swan.ac.uk/Record/cronfa55457
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Abstract: A comprehensive and standardized system to report lipid structures analyzed by mass spectrometry is essentialfor the communication and storage of lipidomics data. Herein, an update on both the LIPID MAPSclassification system and shorthand notation of lipid structures is presented for lipid categories Fatty Acyls(FA), Glycerolipids (GL), Glycerophospholipids (GP), Sphingolipids (SP), and Sterols (ST). With its majorchanges, i.e. annotation of ring double bond equivalents and number of oxygens, the updated shorthandnotation facilitates reporting of newly delineated oxygenated lipid species as well. For standardized reportingin lipidomics, the hierarchical architecture of shorthand notation reflects the diverse structural resolutionpowers provided by mass spectrometric assays. Moreover, shorthand notation is expanded beyond mammalianphyla to lipids from plant and yeast phyla. Finally, annotation of atoms is included for the use of stableisotope-labelled compounds in metabolic labelling experiments or as internal standards.
College: Faculty of Medicine, Health and Life Sciences
Issue: 12
Start Page: 1539
End Page: 1555

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