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A facile synthesis of diaryl pyrroles led to the discovery of potent colchicine site antimitotic agents
Romeo Romagnoli,
Paola Oliva,
Maria Kimatrai Salvador,
Stefano Manfredini,
Chiara Padroni,
Andrea Brancale,
Salvatore Ferla 
,
Ernest Hamel,
Roberto Ronca,
Federica Maccarinelli,
Fatlum Rruga,
Elena Mariotto,
Giampietro Viola,
Roberta Bortolozzi
,
Ernest Hamel,
Roberto Ronca,
Federica Maccarinelli,
Fatlum Rruga,
Elena Mariotto,
Giampietro Viola,
Roberta Bortolozzi
European Journal of Medicinal Chemistry, Volume: 214, Start page: 113229
Swansea University Author:
Salvatore Ferla
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PDF | Accepted Manuscript
©2021 All rights reserved. All article content, except where otherwise noted, is licensed under a Creative Commons Attribution Non-Commercial No Derivatives License (CC-BY-NC-ND)
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DOI (Published version): 10.1016/j.ejmech.2021.113229
Abstract
A facile synthesis of diaryl pyrroles led to the discovery of potent colchicine site antimitotic agents
| Published in: | European Journal of Medicinal Chemistry |
|---|---|
| ISSN: | 0223-5234 1768-3254 |
| Published: |
Elsevier BV
2021
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| Online Access: |
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| URI: | https://cronfa.swan.ac.uk/Record/cronfa56244 |
| Keywords: |
Antimitotic agents; Structure-activity relationship; 1H-pyrrole; Antiproliferative activity; Tubulin polymerization |
|---|---|
| College: |
Faculty of Medicine, Health and Life Sciences |
| Funders: |
We wish to thank Alberto Casolari for technical assistance. R.R. and S.M. acknowledge the support of the PRIN 2017 by grant 2017E84AA4_002. SF is supported by the Sêr Cymru Programme, which is partially funded by the European Regional Development Fund through the Welsh Government. |
| Start Page: |
113229 |