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A facile synthesis of diaryl pyrroles led to the discovery of potent colchicine site antimitotic agents

Romeo Romagnoli, Paola Oliva, Maria Kimatrai Salvador, Stefano Manfredini, Chiara Padroni, Andrea Brancale, Salvatore Ferla Orcid Logo, Ernest Hamel, Roberto Ronca, Federica Maccarinelli, Fatlum Rruga, Elena Mariotto, Giampietro Viola, Roberta Bortolozzi

European Journal of Medicinal Chemistry, Volume: 214, Start page: 113229

Swansea University Author: Salvatore Ferla Orcid Logo

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DOI (Published version): 10.1016/j.ejmech.2021.113229

Published in: European Journal of Medicinal Chemistry
ISSN: 0223-5234 1768-3254
Published: Elsevier BV 2021
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URI: https://cronfa.swan.ac.uk/Record/cronfa56244
first_indexed 2021-02-23T15:14:29Z
last_indexed 2025-01-15T19:59:53Z
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spelling 2025-01-15T13:02:31.5328019 v2 56244 2021-02-12 A facile synthesis of diaryl pyrroles led to the discovery of potent colchicine site antimitotic agents d4c62248f510e3b221916989a7bbe6a6 0000-0002-5918-9237 Salvatore Ferla Salvatore Ferla true false 2021-02-12 MEDS Journal Article European Journal of Medicinal Chemistry 214 113229 Elsevier BV 0223-5234 1768-3254 Antimitotic agents; Structure-activity relationship; 1H-pyrrole; Antiproliferative activity; Tubulin polymerization 15 3 2021 2021-03-15 10.1016/j.ejmech.2021.113229 COLLEGE NANME Medical School COLLEGE CODE MEDS Swansea University Not Required We wish to thank Alberto Casolari for technical assistance. R.R. and S.M. acknowledge the support of the PRIN 2017 by grant 2017E84AA4_002. SF is supported by the Sêr Cymru Programme, which is partially funded by the European Regional Development Fund through the Welsh Government. 2025-01-15T13:02:31.5328019 2021-02-12T11:45:23.4998047 Faculty of Medicine, Health and Life Sciences Swansea University Medical School - Medicine Romeo Romagnoli 1 Paola Oliva 2 Maria Kimatrai Salvador 3 Stefano Manfredini 4 Chiara Padroni 5 Andrea Brancale 6 Salvatore Ferla 0000-0002-5918-9237 7 Ernest Hamel 8 Roberto Ronca 9 Federica Maccarinelli 10 Fatlum Rruga 11 Elena Mariotto 12 Giampietro Viola 13 Roberta Bortolozzi 14 56244__19353__f530d46adb644e9a977cc55dbd95c0d4.pdf 56244.pdf 2021-02-23T16:31:29.5102255 Output 7587066 application/pdf Accepted Manuscript true 2022-01-29T00:00:00.0000000 ©2021 All rights reserved. All article content, except where otherwise noted, is licensed under a Creative Commons Attribution Non-Commercial No Derivatives License (CC-BY-NC-ND) true eng https://creativecommons.org/licenses/by-nc-nd/4.0/
title A facile synthesis of diaryl pyrroles led to the discovery of potent colchicine site antimitotic agents
spellingShingle A facile synthesis of diaryl pyrroles led to the discovery of potent colchicine site antimitotic agents
Salvatore Ferla
title_short A facile synthesis of diaryl pyrroles led to the discovery of potent colchicine site antimitotic agents
title_full A facile synthesis of diaryl pyrroles led to the discovery of potent colchicine site antimitotic agents
title_fullStr A facile synthesis of diaryl pyrroles led to the discovery of potent colchicine site antimitotic agents
title_full_unstemmed A facile synthesis of diaryl pyrroles led to the discovery of potent colchicine site antimitotic agents
title_sort A facile synthesis of diaryl pyrroles led to the discovery of potent colchicine site antimitotic agents
author_id_str_mv d4c62248f510e3b221916989a7bbe6a6
author_id_fullname_str_mv d4c62248f510e3b221916989a7bbe6a6_***_Salvatore Ferla
author Salvatore Ferla
author2 Romeo Romagnoli
Paola Oliva
Maria Kimatrai Salvador
Stefano Manfredini
Chiara Padroni
Andrea Brancale
Salvatore Ferla
Ernest Hamel
Roberto Ronca
Federica Maccarinelli
Fatlum Rruga
Elena Mariotto
Giampietro Viola
Roberta Bortolozzi
format Journal article
container_title European Journal of Medicinal Chemistry
container_volume 214
container_start_page 113229
publishDate 2021
institution Swansea University
issn 0223-5234
1768-3254
doi_str_mv 10.1016/j.ejmech.2021.113229
publisher Elsevier BV
college_str Faculty of Medicine, Health and Life Sciences
hierarchytype
hierarchy_top_id facultyofmedicinehealthandlifesciences
hierarchy_top_title Faculty of Medicine, Health and Life Sciences
hierarchy_parent_id facultyofmedicinehealthandlifesciences
hierarchy_parent_title Faculty of Medicine, Health and Life Sciences
department_str Swansea University Medical School - Medicine{{{_:::_}}}Faculty of Medicine, Health and Life Sciences{{{_:::_}}}Swansea University Medical School - Medicine
document_store_str 1
active_str 0
published_date 2021-03-15T04:51:54Z
_version_ 1856803191874650112
score 11.09611

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