Journal article 717 views 155 downloads
Time-resolved in situ synchrotron-microCT: 4D deformation of bone and bone analogues using digital volume correlation
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Hari Arora ,
Gianluca Tozzi
Acta Biomaterialia, Volume: 131, Pages: 424 - 439
Swansea University Authors:
David Howells, Richard Johnston , Hari Arora
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DOI (Published version): 10.1016/j.actbio.2021.06.014
Abstract
Digital volume correlation (DVC) in combination with high-resolution micro-computed tomography (microCT) imaging and in situ mechanical testing is gaining popularity for quantifying 3D full-field strains in bone and biomaterials. However, traditional in situ time-lapsed (i.e., interrupted) mechanica...
| Published in: | Acta Biomaterialia |
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| ISSN: | 1742-7061 |
| Published: |
Elsevier BV
2021
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| Online Access: |
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| URI: | https://cronfa.swan.ac.uk/Record/cronfa57047 |
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| Abstract: |
Digital volume correlation (DVC) in combination with high-resolution micro-computed tomography (microCT) imaging and in situ mechanical testing is gaining popularity for quantifying 3D full-field strains in bone and biomaterials. However, traditional in situ time-lapsed (i.e., interrupted) mechanical testing cannot fully capture the dynamic strain mechanisms in viscoelastic biological materials. The aim of this study was to investigate the time-resolved deformation of bone structures and analogues via continuous in situ synchrotron-radiation microCT (SR-microCT) compression and DVC to gain a better insight into their structure-function relationships. Fast SR-microCT imaging enabled the deformation behaviour to be captured with high temporal and spatial resolution. Time-resolved DVC highlighted the relationship between local strains and damage initiation and progression in the different biostructures undergoing plastic deformation, bending and/or buckling of their main microstructural elements. The results showed that SR-microCT continuous mechanical testing complemented and enhanced the information obtained from time-lapsed testing, which may underestimate the 3D strain magnitudes as a result of the stress relaxation occurring in between steps before image acquisition in porous biomaterials. Altogether, the findings of this study highlight the importance of time-resolved in situ experiments to fully characterise the time-dependent mechanical behaviour of biological tissues and biomaterials and to further explore their micromechanics under physiologically relevant conditions. |
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| Keywords: |
Bone, time-resolved SR-microCT, continuous in situ mechanics, digital volume correlation, time-dependent behaviour |
| College: |
Faculty of Science and Engineering |
| Start Page: |
424 |
| End Page: |
439 |