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A role for metabolism in determining neonatal immune function

Sean Holm, Benjamin Jenkins, James Cronin Orcid Logo, Nick Jones Orcid Logo, Cathy Thornton Orcid Logo

Pediatric Allergy and Immunology, Volume: 32, Issue: 8, Pages: 1616 - 1628

Swansea University Authors: Sean Holm, Benjamin Jenkins, James Cronin Orcid Logo, Nick Jones Orcid Logo, Cathy Thornton Orcid Logo

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DOI (Published version): 10.1111/pai.13583

Abstract

Immune responses of neonates differ markedly to those of adults, with skewed cytokine phenotypes, reduced inflammatory properties and drastically diminished memory function. Recent research efforts have started to unravel the role of cellular metabolism in determining immune cell fate and function....

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Published in: Pediatric Allergy and Immunology
ISSN: 0905-6157 1399-3038
Published: Wiley 2021
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URI: https://cronfa.swan.ac.uk/Record/cronfa58165
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Recent research efforts have started to unravel the role of cellular metabolism in determining immune cell fate and function. For studies in humans, much of the work on metabolic mechanisms underpinning innate and adaptive immune responses by different haematopoietic cell types is in adults. Studies investigating the contribution of metabolic adaptation in the unique setting of early life are just emerging, and much more work is needed to elucidate the contribution of metabolism to neonatal immune responses. Here, we discuss our current understanding of neonatal immune responses, examine some of the latest developments in neonatal immunometabolism and consider the possible role of altered metabolism to the distinctive immune phenotype of the neonate. Understanding the role of metabolism in regulating immune function at this critical stage in life has direct benefit for the child by affording opportunities to maximize immediate and long-term health. Additionally, gaining insight into the diversity of human immune function and naturally evolved immunometabolic strategies that modulate immune function could be harnessed for a wide range of opportunities including new therapeutic approaches.</abstract><type>Journal Article</type><journal>Pediatric Allergy and Immunology</journal><volume>32</volume><journalNumber>8</journalNumber><paginationStart>1616</paginationStart><paginationEnd>1628</paginationEnd><publisher>Wiley</publisher><placeOfPublication/><isbnPrint/><isbnElectronic/><issnPrint>0905-6157</issnPrint><issnElectronic>1399-3038</issnElectronic><keywords>immunometabolism, metabolic adaptation, neonatal immunity, T cells, umbilical cord blood</keywords><publishedDay>1</publishedDay><publishedMonth>11</publishedMonth><publishedYear>2021</publishedYear><publishedDate>2021-11-01</publishedDate><doi>10.1111/pai.13583</doi><url/><notes/><college>COLLEGE NANME</college><department>Biomedical Sciences</department><CollegeCode>COLLEGE CODE</CollegeCode><DepartmentCode>BMS</DepartmentCode><institution>Swansea University</institution><apcterm>SU Library paid the OA fee (TA Institutional Deal)</apcterm><funders>Not acknowledged in paper - listed on Wiley dashboard. Diabetes UK (GrantNumber(s): 17/0005758; Grant recipient(s): CATHERINE A. THORNTON) Ser Cymru, Welsh Government Medical Research Council (GrantNumber(s): MR/V037013/1; Grant recipient(s): CATHERINE A. 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spelling 2022-01-04T17:20:00.9565361 v2 58165 2021-10-01 A role for metabolism in determining neonatal immune function 90b499d2d76e9eab8ef47a550dfd2c34 Sean Holm Sean Holm true false 90f7cfd66781feba615436189178a528 Benjamin Jenkins Benjamin Jenkins true false 9cfd17551c0d1f7438895121e4fbb6e8 0000-0002-0590-9462 James Cronin James Cronin true false 0fce0f7ddbdbfeb968f4e2f1e3f86744 0000-0003-4846-5117 Nick Jones Nick Jones true false c71a7a4be7361094d046d312202bce0c 0000-0002-5153-573X Cathy Thornton Cathy Thornton true false 2021-10-01 BMS Immune responses of neonates differ markedly to those of adults, with skewed cytokine phenotypes, reduced inflammatory properties and drastically diminished memory function. Recent research efforts have started to unravel the role of cellular metabolism in determining immune cell fate and function. For studies in humans, much of the work on metabolic mechanisms underpinning innate and adaptive immune responses by different haematopoietic cell types is in adults. Studies investigating the contribution of metabolic adaptation in the unique setting of early life are just emerging, and much more work is needed to elucidate the contribution of metabolism to neonatal immune responses. Here, we discuss our current understanding of neonatal immune responses, examine some of the latest developments in neonatal immunometabolism and consider the possible role of altered metabolism to the distinctive immune phenotype of the neonate. Understanding the role of metabolism in regulating immune function at this critical stage in life has direct benefit for the child by affording opportunities to maximize immediate and long-term health. Additionally, gaining insight into the diversity of human immune function and naturally evolved immunometabolic strategies that modulate immune function could be harnessed for a wide range of opportunities including new therapeutic approaches. Journal Article Pediatric Allergy and Immunology 32 8 1616 1628 Wiley 0905-6157 1399-3038 immunometabolism, metabolic adaptation, neonatal immunity, T cells, umbilical cord blood 1 11 2021 2021-11-01 10.1111/pai.13583 COLLEGE NANME Biomedical Sciences COLLEGE CODE BMS Swansea University SU Library paid the OA fee (TA Institutional Deal) Not acknowledged in paper - listed on Wiley dashboard. Diabetes UK (GrantNumber(s): 17/0005758; Grant recipient(s): CATHERINE A. THORNTON) Ser Cymru, Welsh Government Medical Research Council (GrantNumber(s): MR/V037013/1; Grant recipient(s): CATHERINE A. THORNTON) MR/V037013/1 2022-01-04T17:20:00.9565361 2021-10-01T12:42:38.8521718 Faculty of Medicine, Health and Life Sciences Swansea University Medical School - Medicine Sean Holm 1 Benjamin Jenkins 2 James Cronin 0000-0002-0590-9462 3 Nick Jones 0000-0003-4846-5117 4 Cathy Thornton 0000-0002-5153-573X 5 58165__21065__469f05a23fe14199834f33dafa70eb04.pdf 58165.VOR.pai.13583.pdf 2021-10-01T12:55:12.1731745 Output 687502 application/pdf Version of Record true This is an open access article under the terms of the Creative Commons Attribution License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited. © 2021 The Authors. true eng http://creativecommons.org/licenses/by/4.0/
title A role for metabolism in determining neonatal immune function
spellingShingle A role for metabolism in determining neonatal immune function
Sean Holm
Benjamin Jenkins
James Cronin
Nick Jones
Cathy Thornton
title_short A role for metabolism in determining neonatal immune function
title_full A role for metabolism in determining neonatal immune function
title_fullStr A role for metabolism in determining neonatal immune function
title_full_unstemmed A role for metabolism in determining neonatal immune function
title_sort A role for metabolism in determining neonatal immune function
author_id_str_mv 90b499d2d76e9eab8ef47a550dfd2c34
90f7cfd66781feba615436189178a528
9cfd17551c0d1f7438895121e4fbb6e8
0fce0f7ddbdbfeb968f4e2f1e3f86744
c71a7a4be7361094d046d312202bce0c
author_id_fullname_str_mv 90b499d2d76e9eab8ef47a550dfd2c34_***_Sean Holm
90f7cfd66781feba615436189178a528_***_Benjamin Jenkins
9cfd17551c0d1f7438895121e4fbb6e8_***_James Cronin
0fce0f7ddbdbfeb968f4e2f1e3f86744_***_Nick Jones
c71a7a4be7361094d046d312202bce0c_***_Cathy Thornton
author Sean Holm
Benjamin Jenkins
James Cronin
Nick Jones
Cathy Thornton
author2 Sean Holm
Benjamin Jenkins
James Cronin
Nick Jones
Cathy Thornton
format Journal article
container_title Pediatric Allergy and Immunology
container_volume 32
container_issue 8
container_start_page 1616
publishDate 2021
institution Swansea University
issn 0905-6157
1399-3038
doi_str_mv 10.1111/pai.13583
publisher Wiley
college_str Faculty of Medicine, Health and Life Sciences
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hierarchy_top_id facultyofmedicinehealthandlifesciences
hierarchy_top_title Faculty of Medicine, Health and Life Sciences
hierarchy_parent_id facultyofmedicinehealthandlifesciences
hierarchy_parent_title Faculty of Medicine, Health and Life Sciences
department_str Swansea University Medical School - Medicine{{{_:::_}}}Faculty of Medicine, Health and Life Sciences{{{_:::_}}}Swansea University Medical School - Medicine
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description Immune responses of neonates differ markedly to those of adults, with skewed cytokine phenotypes, reduced inflammatory properties and drastically diminished memory function. Recent research efforts have started to unravel the role of cellular metabolism in determining immune cell fate and function. For studies in humans, much of the work on metabolic mechanisms underpinning innate and adaptive immune responses by different haematopoietic cell types is in adults. Studies investigating the contribution of metabolic adaptation in the unique setting of early life are just emerging, and much more work is needed to elucidate the contribution of metabolism to neonatal immune responses. Here, we discuss our current understanding of neonatal immune responses, examine some of the latest developments in neonatal immunometabolism and consider the possible role of altered metabolism to the distinctive immune phenotype of the neonate. Understanding the role of metabolism in regulating immune function at this critical stage in life has direct benefit for the child by affording opportunities to maximize immediate and long-term health. Additionally, gaining insight into the diversity of human immune function and naturally evolved immunometabolic strategies that modulate immune function could be harnessed for a wide range of opportunities including new therapeutic approaches.
published_date 2021-11-01T04:14:28Z
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