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Early-life respiratory tract infections and the risk of school-age lower lung function and asthma: a meta-analysis of 150 000 European children

Evelien R. van Meel, Sara M. Mensink-Bout Orcid Logo, Herman T. den Dekker, Tarunveer S. Ahluwalia, Isabella Annesi-Maesano Orcid Logo, Syed Hasan Arshad, Nour Baïz, Henrique Barros Orcid Logo, Andrea von Berg, Hans Bisgaard, Klaus Bønnelykke, Christian J. Carlsson, Maribel Casas, Leda Chatzi, Cecile Chevrier, Geertje Dalmeijer, Carol Dezateux, Karel Duchen, Merete Eggesbø, Cornelis van der Ent, Maria Fantini, Claudia Flexeder, Urs Frey, Fransesco Forastiere, Ulrike Gehring Orcid Logo, Davide Gori, Raquel Granell, Lucy J. Griffiths, Hazel Inskip, Joanna Jerzynska, Anne M. Karvonen Orcid Logo, Thomas Keil, Cecily Kelleher, Manolis Kogevinas, Gudrun Koppen, Claudia E. Kuehni Orcid Logo, Nathalie Lambrechts, Susanne Lau Orcid Logo, Irina Lehmann, Johnny Ludvigsson, Maria Christine Magnus, Erik Mélen Orcid Logo, John Mehegan, Monique Mommers, Anne-Marie Nybo Andersen, Wenche Nystad, Eva S.L. Pedersen Orcid Logo, Juha Pekkanen Orcid Logo, Ville Peltola, Katharine C. Pike, Angela Pinot de Moira Orcid Logo, Costanza Pizzi, Kinga Polanska, Maja Popovic Orcid Logo, Daniela Porta Orcid Logo, Graham Roberts, Ana Cristina Santos, Erica S. Schultz, Marie Standl, Jordi Sunyer, Carel Thijs, Laura Toivonen, Eleonora Uphoff, Jakob Usemann Orcid Logo, Marina Vafeidi, John Wright, Johan C. de Jongste, Vincent W.V. Jaddoe, Liesbeth Duijts Orcid Logo, Lucy Griffiths Orcid Logo

European Respiratory Journal, Volume: 60, Issue: 4, Start page: 2102395

Swansea University Author: Lucy Griffiths Orcid Logo

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Abstract

Background Early-life respiratory tract infections might affect chronic obstructive respiratory diseases, but conclusive studies from general populations are lacking. Our objective was to examine if children with early-life respiratory tract infections had increased risks of lower lung function and...

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Published in: European Respiratory Journal
ISSN: 0903-1936 1399-3003
Published: European Respiratory Society (ERS) 2022
Online Access: Check full text

URI: https://cronfa.swan.ac.uk/Record/cronfa59952
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Abstract: Background Early-life respiratory tract infections might affect chronic obstructive respiratory diseases, but conclusive studies from general populations are lacking. Our objective was to examine if children with early-life respiratory tract infections had increased risks of lower lung function and asthma at school age.Methods We used individual participant data of 150 090 children primarily from the EU Child Cohort Network to examine the associations of upper and lower respiratory tract infections from age 6 months to 5 years with forced expiratory volume in 1 s (FEV1), forced vital capacity (FVC), FEV1/FVC, forced expiratory flow at 75% of FVC (FEF75%) and asthma at a median (range) age of 7 (4–15) years.Results Children with early-life lower, not upper, respiratory tract infections had a lower school-age FEV1, FEV1/FVC and FEF75% (z-score range: −0.09 (95% CI −0.14– −0.04) to −0.30 (95% CI −0.36– −0.24)). Children with early-life lower respiratory tract infections had a higher increased risk of school-age asthma than those with upper respiratory tract infections (OR range: 2.10 (95% CI 1.98–2.22) to 6.30 (95% CI 5.64–7.04) and 1.25 (95% CI 1.18–1.32) to 1.55 (95% CI 1.47–1.65), respectively). Adjustment for preceding respiratory tract infections slightly decreased the strength of the effects. Observed associations were similar for those with and without early-life wheezing as a proxy for early-life asthma.Conclusions Our findings suggest that early-life respiratory tract infections affect development of chronic obstructive respiratory diseases in later life, with the strongest effects for lower respiratory tract infections.
Keywords: Epidemiology, meta-analysis, pediatrics, respiratory tract infections, respiratory function tests, asthma
College: Faculty of Medicine, Health and Life Sciences
Issue: 4
Start Page: 2102395