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Early-life respiratory tract infections and the risk of school-age lower lung function and asthma: a meta-analysis of 150 000 European children

Evelien R. van Meel, Sara M. Mensink-Bout Orcid Logo, Herman T. den Dekker, Tarunveer S. Ahluwalia, Isabella Annesi-Maesano Orcid Logo, Syed Hasan Arshad, Nour Baïz, Henrique Barros Orcid Logo, Andrea von Berg, Hans Bisgaard, Klaus Bønnelykke, Christian J. Carlsson, Maribel Casas, Leda Chatzi, Cecile Chevrier, Geertje Dalmeijer, Carol Dezateux, Karel Duchen, Merete Eggesbø, Cornelis van der Ent, Maria Fantini, Claudia Flexeder, Urs Frey, Fransesco Forastiere, Ulrike Gehring Orcid Logo, Davide Gori, Raquel Granell, Lucy J. Griffiths, Hazel Inskip, Joanna Jerzynska, Anne M. Karvonen Orcid Logo, Thomas Keil, Cecily Kelleher, Manolis Kogevinas, Gudrun Koppen, Claudia E. Kuehni Orcid Logo, Nathalie Lambrechts, Susanne Lau Orcid Logo, Irina Lehmann, Johnny Ludvigsson, Maria Christine Magnus, Erik Mélen Orcid Logo, John Mehegan, Monique Mommers, Anne-Marie Nybo Andersen, Wenche Nystad, Eva S.L. Pedersen Orcid Logo, Juha Pekkanen Orcid Logo, Ville Peltola, Katharine C. Pike, Angela Pinot de Moira Orcid Logo, Costanza Pizzi, Kinga Polanska, Maja Popovic Orcid Logo, Daniela Porta Orcid Logo, Graham Roberts, Ana Cristina Santos, Erica S. Schultz, Marie Standl, Jordi Sunyer, Carel Thijs, Laura Toivonen, Eleonora Uphoff, Jakob Usemann Orcid Logo, Marina Vafeidi, John Wright, Johan C. de Jongste, Vincent W.V. Jaddoe, Liesbeth Duijts Orcid Logo, Lucy Griffiths Orcid Logo

European Respiratory Journal, Volume: 60, Issue: 4, Start page: 2102395

Swansea University Author: Lucy Griffiths Orcid Logo

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DOI (Published version): 10.1183/13993003.02395-2021

Abstract

Background Early-life respiratory tract infections might affect chronic obstructive respiratory diseases, but conclusive studies from general populations are lacking. Our objective was to examine if children with early-life respiratory tract infections had increased risks of lower lung function and...

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Published in: European Respiratory Journal
ISSN: 0903-1936 1399-3003
Published: European Respiratory Society (ERS) 2022
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Our objective was to examine if children with early-life respiratory tract infections had increased risks of lower lung function and asthma at school age.Methods We used individual participant data of 150&#x2009;090 children primarily from the EU Child Cohort Network to examine the associations of upper and lower respiratory tract infections from age 6&#x2005;months to 5&#x2005;years with forced expiratory volume in 1&#x2005;s (FEV1), forced vital capacity (FVC), FEV1/FVC, forced expiratory flow at 75% of FVC (FEF75%) and asthma at a median (range) age of 7 (4&#x2013;15)&#x2005;years.Results Children with early-life lower, not upper, respiratory tract infections had a lower school-age FEV1, FEV1/FVC and FEF75% (z-score range: &#x2212;0.09 (95% CI &#x2212;0.14&#x2013;&#x2009;&#x2212;0.04) to &#x2212;0.30 (95% CI &#x2212;0.36&#x2013;&#x2009;&#x2212;0.24)). Children with early-life lower respiratory tract infections had a higher increased risk of school-age asthma than those with upper respiratory tract infections (OR range: 2.10 (95% CI 1.98&#x2013;2.22) to 6.30 (95% CI 5.64&#x2013;7.04) and 1.25 (95% CI 1.18&#x2013;1.32) to 1.55 (95% CI 1.47&#x2013;1.65), respectively). Adjustment for preceding respiratory tract infections slightly decreased the strength of the effects. Observed associations were similar for those with and without early-life wheezing as a proxy for early-life asthma.Conclusions Our findings suggest that early-life respiratory tract infections affect development of chronic obstructive respiratory diseases in later life, with the strongest effects for lower respiratory tract infections.</abstract><type>Journal Article</type><journal>European Respiratory Journal</journal><volume>60</volume><journalNumber>4</journalNumber><paginationStart>2102395</paginationStart><paginationEnd/><publisher>European Respiratory Society (ERS)</publisher><placeOfPublication/><isbnPrint/><isbnElectronic/><issnPrint>0903-1936</issnPrint><issnElectronic>1399-3003</issnElectronic><keywords>Epidemiology, meta-analysis, pediatrics, respiratory tract infections, respiratory function tests, asthma</keywords><publishedDay>6</publishedDay><publishedMonth>10</publishedMonth><publishedYear>2022</publishedYear><publishedDate>2022-10-06</publishedDate><doi>10.1183/13993003.02395-2021</doi><url/><notes/><college>COLLEGE NANME</college><department>Medical School</department><CollegeCode>COLLEGE CODE</CollegeCode><DepartmentCode>MEDS</DepartmentCode><institution>Swansea University</institution><apcterm/><funders/><projectreference/><lastEdited>2022-11-20T12:52:56.7083721</lastEdited><Created>2022-05-04T16:31:24.5221585</Created><path><level id="1">Faculty of Medicine, Health and Life Sciences</level><level id="2">Swansea University Medical School - Medicine</level></path><authors><author><firstname>Evelien R. van</firstname><surname>Meel</surname><order>1</order></author><author><firstname>Sara M.</firstname><surname>Mensink-Bout</surname><orcid>0000-0002-5381-6287</orcid><order>2</order></author><author><firstname>Herman T. den</firstname><surname>Dekker</surname><order>3</order></author><author><firstname>Tarunveer S.</firstname><surname>Ahluwalia</surname><order>4</order></author><author><firstname>Isabella</firstname><surname>Annesi-Maesano</surname><orcid>0000-0002-6340-9300</orcid><order>5</order></author><author><firstname>Syed Hasan</firstname><surname>Arshad</surname><order>6</order></author><author><firstname>Nour</firstname><surname>Ba&#xEF;z</surname><order>7</order></author><author><firstname>Henrique</firstname><surname>Barros</surname><orcid>0000-0003-4699-6571</orcid><order>8</order></author><author><firstname>Andrea von</firstname><surname>Berg</surname><order>9</order></author><author><firstname>Hans</firstname><surname>Bisgaard</surname><order>10</order></author><author><firstname>Klaus</firstname><surname>B&#xF8;nnelykke</surname><order>11</order></author><author><firstname>Christian J.</firstname><surname>Carlsson</surname><order>12</order></author><author><firstname>Maribel</firstname><surname>Casas</surname><order>13</order></author><author><firstname>Leda</firstname><surname>Chatzi</surname><order>14</order></author><author><firstname>Cecile</firstname><surname>Chevrier</surname><order>15</order></author><author><firstname>Geertje</firstname><surname>Dalmeijer</surname><order>16</order></author><author><firstname>Carol</firstname><surname>Dezateux</surname><order>17</order></author><author><firstname>Karel</firstname><surname>Duchen</surname><order>18</order></author><author><firstname>Merete</firstname><surname>Eggesb&#xF8;</surname><order>19</order></author><author><firstname>Cornelis van der</firstname><surname>Ent</surname><order>20</order></author><author><firstname>Maria</firstname><surname>Fantini</surname><order>21</order></author><author><firstname>Claudia</firstname><surname>Flexeder</surname><order>22</order></author><author><firstname>Urs</firstname><surname>Frey</surname><order>23</order></author><author><firstname>Fransesco</firstname><surname>Forastiere</surname><order>24</order></author><author><firstname>Ulrike</firstname><surname>Gehring</surname><orcid>0000-0003-3612-5780</orcid><order>25</order></author><author><firstname>Davide</firstname><surname>Gori</surname><order>26</order></author><author><firstname>Raquel</firstname><surname>Granell</surname><order>27</order></author><author><firstname>Lucy J.</firstname><surname>Griffiths</surname><order>28</order></author><author><firstname>Hazel</firstname><surname>Inskip</surname><order>29</order></author><author><firstname>Joanna</firstname><surname>Jerzynska</surname><order>30</order></author><author><firstname>Anne M.</firstname><surname>Karvonen</surname><orcid>0000-0003-2257-2934</orcid><order>31</order></author><author><firstname>Thomas</firstname><surname>Keil</surname><order>32</order></author><author><firstname>Cecily</firstname><surname>Kelleher</surname><order>33</order></author><author><firstname>Manolis</firstname><surname>Kogevinas</surname><order>34</order></author><author><firstname>Gudrun</firstname><surname>Koppen</surname><order>35</order></author><author><firstname>Claudia E.</firstname><surname>Kuehni</surname><orcid>0000-0001-8957-2002</orcid><order>36</order></author><author><firstname>Nathalie</firstname><surname>Lambrechts</surname><order>37</order></author><author><firstname>Susanne</firstname><surname>Lau</surname><orcid>0000-0002-5189-4265</orcid><order>38</order></author><author><firstname>Irina</firstname><surname>Lehmann</surname><order>39</order></author><author><firstname>Johnny</firstname><surname>Ludvigsson</surname><order>40</order></author><author><firstname>Maria Christine</firstname><surname>Magnus</surname><order>41</order></author><author><firstname>Erik</firstname><surname>M&#xE9;len</surname><orcid>0000-0002-8248-0663</orcid><order>42</order></author><author><firstname>John</firstname><surname>Mehegan</surname><order>43</order></author><author><firstname>Monique</firstname><surname>Mommers</surname><order>44</order></author><author><firstname>Anne-Marie Nybo</firstname><surname>Andersen</surname><order>45</order></author><author><firstname>Wenche</firstname><surname>Nystad</surname><order>46</order></author><author><firstname>Eva S.L.</firstname><surname>Pedersen</surname><orcid>0000-0003-0293-9954</orcid><order>47</order></author><author><firstname>Juha</firstname><surname>Pekkanen</surname><orcid>0000-0002-1083-8777</orcid><order>48</order></author><author><firstname>Ville</firstname><surname>Peltola</surname><order>49</order></author><author><firstname>Katharine C.</firstname><surname>Pike</surname><order>50</order></author><author><firstname>Angela Pinot de</firstname><surname>Moira</surname><orcid>0000-0003-3593-8472</orcid><order>51</order></author><author><firstname>Costanza</firstname><surname>Pizzi</surname><order>52</order></author><author><firstname>Kinga</firstname><surname>Polanska</surname><order>53</order></author><author><firstname>Maja</firstname><surname>Popovic</surname><orcid>0000-0003-4500-6572</orcid><order>54</order></author><author><firstname>Daniela</firstname><surname>Porta</surname><orcid>0000-0002-3431-2729</orcid><order>55</order></author><author><firstname>Graham</firstname><surname>Roberts</surname><order>56</order></author><author><firstname>Ana Cristina</firstname><surname>Santos</surname><order>57</order></author><author><firstname>Erica S.</firstname><surname>Schultz</surname><order>58</order></author><author><firstname>Marie</firstname><surname>Standl</surname><order>59</order></author><author><firstname>Jordi</firstname><surname>Sunyer</surname><order>60</order></author><author><firstname>Carel</firstname><surname>Thijs</surname><order>61</order></author><author><firstname>Laura</firstname><surname>Toivonen</surname><order>62</order></author><author><firstname>Eleonora</firstname><surname>Uphoff</surname><order>63</order></author><author><firstname>Jakob</firstname><surname>Usemann</surname><orcid>0000-0002-9987-2866</orcid><order>64</order></author><author><firstname>Marina</firstname><surname>Vafeidi</surname><order>65</order></author><author><firstname>John</firstname><surname>Wright</surname><order>66</order></author><author><firstname>Johan C. de</firstname><surname>Jongste</surname><order>67</order></author><author><firstname>Vincent W.V.</firstname><surname>Jaddoe</surname><order>68</order></author><author><firstname>Liesbeth</firstname><surname>Duijts</surname><orcid>0000-0001-6731-9452</orcid><order>69</order></author><author><firstname>Lucy</firstname><surname>Griffiths</surname><orcid>0000-0001-9230-624X</orcid><order>70</order></author></authors><documents><document><filename>59952__25839__9ed270266f734f8ba14b8ef68e1412f3.pdf</filename><originalFilename>59952_VoR.pdf</originalFilename><uploaded>2022-11-20T12:51:01.3300191</uploaded><type>Output</type><contentLength>1194452</contentLength><contentType>application/pdf</contentType><version>Version of Record</version><cronfaStatus>true</cronfaStatus><documentNotes>&#xA9;The authors 2022. This version is distributed under the terms of the Creative Commons Attribution Non-Commercial Licence 4.0. For commercial reproduction rights and permissions contact permissions@ersnet.org</documentNotes><copyrightCorrect>true</copyrightCorrect><language>eng</language><licence>https://creativecommons.org/licenses/by-nc/4.0/</licence></document></documents><OutputDurs/></rfc1807>
spelling 2022-11-20T12:52:56.7083721 v2 59952 2022-05-04 Early-life respiratory tract infections and the risk of school-age lower lung function and asthma: a meta-analysis of 150 000 European children e35ea6ea4b429e812ef204b048131d93 0000-0001-9230-624X Lucy Griffiths Lucy Griffiths true false 2022-05-04 MEDS Background Early-life respiratory tract infections might affect chronic obstructive respiratory diseases, but conclusive studies from general populations are lacking. Our objective was to examine if children with early-life respiratory tract infections had increased risks of lower lung function and asthma at school age.Methods We used individual participant data of 150 090 children primarily from the EU Child Cohort Network to examine the associations of upper and lower respiratory tract infections from age 6 months to 5 years with forced expiratory volume in 1 s (FEV1), forced vital capacity (FVC), FEV1/FVC, forced expiratory flow at 75% of FVC (FEF75%) and asthma at a median (range) age of 7 (4–15) years.Results Children with early-life lower, not upper, respiratory tract infections had a lower school-age FEV1, FEV1/FVC and FEF75% (z-score range: −0.09 (95% CI −0.14– −0.04) to −0.30 (95% CI −0.36– −0.24)). Children with early-life lower respiratory tract infections had a higher increased risk of school-age asthma than those with upper respiratory tract infections (OR range: 2.10 (95% CI 1.98–2.22) to 6.30 (95% CI 5.64–7.04) and 1.25 (95% CI 1.18–1.32) to 1.55 (95% CI 1.47–1.65), respectively). Adjustment for preceding respiratory tract infections slightly decreased the strength of the effects. Observed associations were similar for those with and without early-life wheezing as a proxy for early-life asthma.Conclusions Our findings suggest that early-life respiratory tract infections affect development of chronic obstructive respiratory diseases in later life, with the strongest effects for lower respiratory tract infections. Journal Article European Respiratory Journal 60 4 2102395 European Respiratory Society (ERS) 0903-1936 1399-3003 Epidemiology, meta-analysis, pediatrics, respiratory tract infections, respiratory function tests, asthma 6 10 2022 2022-10-06 10.1183/13993003.02395-2021 COLLEGE NANME Medical School COLLEGE CODE MEDS Swansea University 2022-11-20T12:52:56.7083721 2022-05-04T16:31:24.5221585 Faculty of Medicine, Health and Life Sciences Swansea University Medical School - Medicine Evelien R. van Meel 1 Sara M. Mensink-Bout 0000-0002-5381-6287 2 Herman T. den Dekker 3 Tarunveer S. Ahluwalia 4 Isabella Annesi-Maesano 0000-0002-6340-9300 5 Syed Hasan Arshad 6 Nour Baïz 7 Henrique Barros 0000-0003-4699-6571 8 Andrea von Berg 9 Hans Bisgaard 10 Klaus Bønnelykke 11 Christian J. Carlsson 12 Maribel Casas 13 Leda Chatzi 14 Cecile Chevrier 15 Geertje Dalmeijer 16 Carol Dezateux 17 Karel Duchen 18 Merete Eggesbø 19 Cornelis van der Ent 20 Maria Fantini 21 Claudia Flexeder 22 Urs Frey 23 Fransesco Forastiere 24 Ulrike Gehring 0000-0003-3612-5780 25 Davide Gori 26 Raquel Granell 27 Lucy J. Griffiths 28 Hazel Inskip 29 Joanna Jerzynska 30 Anne M. Karvonen 0000-0003-2257-2934 31 Thomas Keil 32 Cecily Kelleher 33 Manolis Kogevinas 34 Gudrun Koppen 35 Claudia E. Kuehni 0000-0001-8957-2002 36 Nathalie Lambrechts 37 Susanne Lau 0000-0002-5189-4265 38 Irina Lehmann 39 Johnny Ludvigsson 40 Maria Christine Magnus 41 Erik Mélen 0000-0002-8248-0663 42 John Mehegan 43 Monique Mommers 44 Anne-Marie Nybo Andersen 45 Wenche Nystad 46 Eva S.L. Pedersen 0000-0003-0293-9954 47 Juha Pekkanen 0000-0002-1083-8777 48 Ville Peltola 49 Katharine C. Pike 50 Angela Pinot de Moira 0000-0003-3593-8472 51 Costanza Pizzi 52 Kinga Polanska 53 Maja Popovic 0000-0003-4500-6572 54 Daniela Porta 0000-0002-3431-2729 55 Graham Roberts 56 Ana Cristina Santos 57 Erica S. Schultz 58 Marie Standl 59 Jordi Sunyer 60 Carel Thijs 61 Laura Toivonen 62 Eleonora Uphoff 63 Jakob Usemann 0000-0002-9987-2866 64 Marina Vafeidi 65 John Wright 66 Johan C. de Jongste 67 Vincent W.V. Jaddoe 68 Liesbeth Duijts 0000-0001-6731-9452 69 Lucy Griffiths 0000-0001-9230-624X 70 59952__25839__9ed270266f734f8ba14b8ef68e1412f3.pdf 59952_VoR.pdf 2022-11-20T12:51:01.3300191 Output 1194452 application/pdf Version of Record true ©The authors 2022. This version is distributed under the terms of the Creative Commons Attribution Non-Commercial Licence 4.0. For commercial reproduction rights and permissions contact permissions@ersnet.org true eng https://creativecommons.org/licenses/by-nc/4.0/
title Early-life respiratory tract infections and the risk of school-age lower lung function and asthma: a meta-analysis of 150 000 European children
spellingShingle Early-life respiratory tract infections and the risk of school-age lower lung function and asthma: a meta-analysis of 150 000 European children
Lucy Griffiths
title_short Early-life respiratory tract infections and the risk of school-age lower lung function and asthma: a meta-analysis of 150 000 European children
title_full Early-life respiratory tract infections and the risk of school-age lower lung function and asthma: a meta-analysis of 150 000 European children
title_fullStr Early-life respiratory tract infections and the risk of school-age lower lung function and asthma: a meta-analysis of 150 000 European children
title_full_unstemmed Early-life respiratory tract infections and the risk of school-age lower lung function and asthma: a meta-analysis of 150 000 European children
title_sort Early-life respiratory tract infections and the risk of school-age lower lung function and asthma: a meta-analysis of 150 000 European children
author_id_str_mv e35ea6ea4b429e812ef204b048131d93
author_id_fullname_str_mv e35ea6ea4b429e812ef204b048131d93_***_Lucy Griffiths
author Lucy Griffiths
author2 Evelien R. van Meel
Sara M. Mensink-Bout
Herman T. den Dekker
Tarunveer S. Ahluwalia
Isabella Annesi-Maesano
Syed Hasan Arshad
Nour Baïz
Henrique Barros
Andrea von Berg
Hans Bisgaard
Klaus Bønnelykke
Christian J. Carlsson
Maribel Casas
Leda Chatzi
Cecile Chevrier
Geertje Dalmeijer
Carol Dezateux
Karel Duchen
Merete Eggesbø
Cornelis van der Ent
Maria Fantini
Claudia Flexeder
Urs Frey
Fransesco Forastiere
Ulrike Gehring
Davide Gori
Raquel Granell
Lucy J. Griffiths
Hazel Inskip
Joanna Jerzynska
Anne M. Karvonen
Thomas Keil
Cecily Kelleher
Manolis Kogevinas
Gudrun Koppen
Claudia E. Kuehni
Nathalie Lambrechts
Susanne Lau
Irina Lehmann
Johnny Ludvigsson
Maria Christine Magnus
Erik Mélen
John Mehegan
Monique Mommers
Anne-Marie Nybo Andersen
Wenche Nystad
Eva S.L. Pedersen
Juha Pekkanen
Ville Peltola
Katharine C. Pike
Angela Pinot de Moira
Costanza Pizzi
Kinga Polanska
Maja Popovic
Daniela Porta
Graham Roberts
Ana Cristina Santos
Erica S. Schultz
Marie Standl
Jordi Sunyer
Carel Thijs
Laura Toivonen
Eleonora Uphoff
Jakob Usemann
Marina Vafeidi
John Wright
Johan C. de Jongste
Vincent W.V. Jaddoe
Liesbeth Duijts
Lucy Griffiths
format Journal article
container_title European Respiratory Journal
container_volume 60
container_issue 4
container_start_page 2102395
publishDate 2022
institution Swansea University
issn 0903-1936
1399-3003
doi_str_mv 10.1183/13993003.02395-2021
publisher European Respiratory Society (ERS)
college_str Faculty of Medicine, Health and Life Sciences
hierarchytype
hierarchy_top_id facultyofmedicinehealthandlifesciences
hierarchy_top_title Faculty of Medicine, Health and Life Sciences
hierarchy_parent_id facultyofmedicinehealthandlifesciences
hierarchy_parent_title Faculty of Medicine, Health and Life Sciences
department_str Swansea University Medical School - Medicine{{{_:::_}}}Faculty of Medicine, Health and Life Sciences{{{_:::_}}}Swansea University Medical School - Medicine
document_store_str 1
active_str 0
description Background Early-life respiratory tract infections might affect chronic obstructive respiratory diseases, but conclusive studies from general populations are lacking. Our objective was to examine if children with early-life respiratory tract infections had increased risks of lower lung function and asthma at school age.Methods We used individual participant data of 150 090 children primarily from the EU Child Cohort Network to examine the associations of upper and lower respiratory tract infections from age 6 months to 5 years with forced expiratory volume in 1 s (FEV1), forced vital capacity (FVC), FEV1/FVC, forced expiratory flow at 75% of FVC (FEF75%) and asthma at a median (range) age of 7 (4–15) years.Results Children with early-life lower, not upper, respiratory tract infections had a lower school-age FEV1, FEV1/FVC and FEF75% (z-score range: −0.09 (95% CI −0.14– −0.04) to −0.30 (95% CI −0.36– −0.24)). Children with early-life lower respiratory tract infections had a higher increased risk of school-age asthma than those with upper respiratory tract infections (OR range: 2.10 (95% CI 1.98–2.22) to 6.30 (95% CI 5.64–7.04) and 1.25 (95% CI 1.18–1.32) to 1.55 (95% CI 1.47–1.65), respectively). Adjustment for preceding respiratory tract infections slightly decreased the strength of the effects. Observed associations were similar for those with and without early-life wheezing as a proxy for early-life asthma.Conclusions Our findings suggest that early-life respiratory tract infections affect development of chronic obstructive respiratory diseases in later life, with the strongest effects for lower respiratory tract infections.
published_date 2022-10-06T14:12:21Z
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score 11.516414

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