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Green tea polyphenols in cardiometabolic health: A critical appraisal on phytogenomics towards personalized green tea

Logesh Rajan, Arun Radhakrishnan, Keshav Narayan Alagarsamy, Abhay Srivastava, Sanjiv Dhingra, Anthony Booker, Viven Rolfe, Dhanabal Palaniswamy, Suresh Kumar Mohankumar

PharmaNutrition, Volume: 20, Start page: 100296

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DOI (Published version): 10.1016/j.phanu.2022.100296

Abstract

Cardiovascular disease is a chronic multifactorial health complication that is either directly or indirectly associated with pathophysiological mechanisms, including pro-oxidation, pro-inflammation, vascular and endothelial dysfunction, impaired platelet function, thrombosis, and others. The therape...

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Published in: PharmaNutrition
ISSN: 2213-4344
Published: Elsevier BV 2022
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URI: https://cronfa.swan.ac.uk/Record/cronfa60089
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spelling 2023-02-16T15:55:55.4739730 v2 60089 2022-05-26 Green tea polyphenols in cardiometabolic health: A critical appraisal on phytogenomics towards personalized green tea 2022-05-26 Cardiovascular disease is a chronic multifactorial health complication that is either directly or indirectly associated with pathophysiological mechanisms, including pro-oxidation, pro-inflammation, vascular and endothelial dysfunction, impaired platelet function, thrombosis, and others. The therapeutic options to circumvent cardiovascular complications include several phytomedicines, including green tea polyphenols. However, while many experimental and clinical studies report distinct mechanisms by which the polyphenols of green tea elicit a beneficial role in cardiometabolic health, the translation and applications of green tea polyphenols in clinics have yet to gain their optimal use on the broader population. This review critically appraises the various reported mechanisms of green tea polyphenols in modulating cardio-metabolic health and associated phyto-genomic challenges. Further, our review highlights the probability of gene polymorphic associated therapeutic variations in individuals using green tea for cardio-metabolic effects and the necessity to personalize green tea for clinical use, thereby improvising the risk-benefit ratio. Journal Article PharmaNutrition 20 100296 Elsevier BV 2213-4344 Green tea polyphenols; Cardiovascular disease; Inter-individual variability; Genetic polymorphism; Phyto-genomic 1 6 2022 2022-06-01 10.1016/j.phanu.2022.100296 COLLEGE NANME COLLEGE CODE Swansea University SU Library paid the OA fee (TA Institutional Deal) No financial and/or material support was received for this research and/or the creation of this work. 2023-02-16T15:55:55.4739730 2022-05-26T13:28:51.5871573 Faculty of Medicine, Health and Life Sciences Swansea University Medical School - Medicine Logesh Rajan 1 Arun Radhakrishnan 2 Keshav Narayan Alagarsamy 3 Abhay Srivastava 4 Sanjiv Dhingra 5 Anthony Booker 6 Viven Rolfe 7 Dhanabal Palaniswamy 8 Suresh Kumar Mohankumar 9 60089__24192__edc9ba25dd0f4f8ab4764e1d902afd7a.pdf 60089.pdf 2022-05-26T13:31:26.0243320 Output 1889974 application/pdf Version of Record true © 2022 The Authors. This is an open access article under the CC BY-NC-ND license true eng http://creativecommons.org/licenses/by-nc-nd/4.0/
title Green tea polyphenols in cardiometabolic health: A critical appraisal on phytogenomics towards personalized green tea
spellingShingle Green tea polyphenols in cardiometabolic health: A critical appraisal on phytogenomics towards personalized green tea
,
title_short Green tea polyphenols in cardiometabolic health: A critical appraisal on phytogenomics towards personalized green tea
title_full Green tea polyphenols in cardiometabolic health: A critical appraisal on phytogenomics towards personalized green tea
title_fullStr Green tea polyphenols in cardiometabolic health: A critical appraisal on phytogenomics towards personalized green tea
title_full_unstemmed Green tea polyphenols in cardiometabolic health: A critical appraisal on phytogenomics towards personalized green tea
title_sort Green tea polyphenols in cardiometabolic health: A critical appraisal on phytogenomics towards personalized green tea
author ,
author2 Logesh Rajan
Arun Radhakrishnan
Keshav Narayan Alagarsamy
Abhay Srivastava
Sanjiv Dhingra
Anthony Booker
Viven Rolfe
Dhanabal Palaniswamy
Suresh Kumar Mohankumar
format Journal article
container_title PharmaNutrition
container_volume 20
container_start_page 100296
publishDate 2022
institution Swansea University
issn 2213-4344
doi_str_mv 10.1016/j.phanu.2022.100296
publisher Elsevier BV
college_str Faculty of Medicine, Health and Life Sciences
hierarchytype
hierarchy_top_id facultyofmedicinehealthandlifesciences
hierarchy_top_title Faculty of Medicine, Health and Life Sciences
hierarchy_parent_id facultyofmedicinehealthandlifesciences
hierarchy_parent_title Faculty of Medicine, Health and Life Sciences
department_str Swansea University Medical School - Medicine{{{_:::_}}}Faculty of Medicine, Health and Life Sciences{{{_:::_}}}Swansea University Medical School - Medicine
document_store_str 1
active_str 0
description Cardiovascular disease is a chronic multifactorial health complication that is either directly or indirectly associated with pathophysiological mechanisms, including pro-oxidation, pro-inflammation, vascular and endothelial dysfunction, impaired platelet function, thrombosis, and others. The therapeutic options to circumvent cardiovascular complications include several phytomedicines, including green tea polyphenols. However, while many experimental and clinical studies report distinct mechanisms by which the polyphenols of green tea elicit a beneficial role in cardiometabolic health, the translation and applications of green tea polyphenols in clinics have yet to gain their optimal use on the broader population. This review critically appraises the various reported mechanisms of green tea polyphenols in modulating cardio-metabolic health and associated phyto-genomic challenges. Further, our review highlights the probability of gene polymorphic associated therapeutic variations in individuals using green tea for cardio-metabolic effects and the necessity to personalize green tea for clinical use, thereby improvising the risk-benefit ratio.
published_date 2022-06-01T04:17:54Z
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score 11.037056

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