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PEGylated Gold Nanoparticles Target Age-Associated B Cells In Vivo
,
Viola Puddinu ,
Laetitia Haeni,
Alke Petri-Fink ,
Julia Wagner,
Montserrat Alvarez,
Martin Clift ,
Carole Bourquin
ACS Nano, Volume: 16, Issue: 11, Pages: 18119 - 18132
Swansea University Author:
Martin Clift
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DOI (Published version): 10.1021/acsnano.2c04871
Abstract
Engineered gold nanoparticles (GNPs) have become a useful tool in various therapeutic and diagnostic applications. Uncertainty remains regarding the possible impact of GNPs on the immune system. In this regard, we investigated the interactions of polymer-coated GNPs with B cells and their functions...
| Published in: | ACS Nano |
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| ISSN: | 1936-0851 1936-086X |
| Published: |
American Chemical Society (ACS)
2022
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| Online Access: |
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| URI: | https://cronfa.swan.ac.uk/Record/cronfa61638 |
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| Abstract: |
Engineered gold nanoparticles (GNPs) have become a useful tool in various therapeutic and diagnostic applications. Uncertainty remains regarding the possible impact of GNPs on the immune system. In this regard, we investigated the interactions of polymer-coated GNPs with B cells and their functions in mice. Surprisingly, we observed that polymer-coated GNPs mainly interact with the recently identified subpopulation of B lymphocytes named age-associated B cells (ABCs). Importantly, we also showed that GNPs did not affect cell viability or the percentages of other B cell populations in different organs. Furthermore, GNPs did not activate B cell innate-like immune responses in any of the tested conditions, nor did they impair adaptive B cell responses in immunized mice. Together, these data provide an important contribution to the otherwise limited knowledge about GNP interference with B cell immune function, and demonstrate that GNPs represent a safe tool to target ABCs in vivo for potential clinical applications. |
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| Item Description: |
PMCID# PMC9706664 |
| Keywords: |
gold nanoparticles; polymer-coating; in vivo toxicity; targeted delivery, B cells, age-associated B cells |
| College: |
Faculty of Medicine, Health and Life Sciences |
| Funders: |
Schweizerischer Nationalfonds zur Förderung der Wissenschaftlichen Forschung - 156372, 156871, 182317; Adolphe Merkle Foundation |
| Issue: |
11 |
| Start Page: |
18119 |
| End Page: |
18132 |