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Diversity and environmental adaptation of phagocytic cell metabolism
,
Christopher M. Rice,
Daniel W. McVicar,
Jonathan M. Weiss
Journal of Leukocyte Biology, Volume: 105, Issue: 1, Pages: 37 - 48
Swansea University Author:
Luke Davies
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DOI (Published version): 10.1002/jlb.4ri0518-195r
Abstract
Phagocytes are cells of the immune system that play important roles in phagocytosis, respiratory burst and degranulation—key components of innate immunity and response to infection. This diverse group of cells includes monocytes, macrophages, dendritic cells, neutrophils, eosinophils, and basophils—...
| Published in: | Journal of Leukocyte Biology |
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| ISSN: | 0741-5400 1938-3673 |
| Published: |
Wiley
2019
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| Online Access: |
Check full text
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| URI: | https://cronfa.swan.ac.uk/Record/cronfa61699 |
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| Abstract: |
Phagocytes are cells of the immune system that play important roles in phagocytosis, respiratory burst and degranulation—key components of innate immunity and response to infection. This diverse group of cells includes monocytes, macrophages, dendritic cells, neutrophils, eosinophils, and basophils—heterogeneous cell populations possessing cell and tissue-specific functions of which cellular metabolism comprises a critical underpinning. Core functions of phagocytic cells are diverse and sensitive to alterations in environmental- and tissue-specific nutrients and growth factors. As phagocytic cells adapt to these extracellular cues, cellular processes are altered and may contribute to pathogenesis. The considerable degree of functional heterogeneity among monocyte, neutrophil, and other phagocytic cell populations necessitates diverse metabolism. As we review our current understanding of metabolism in phagocytic cells, gaps are focused on to highlight the need for additional studies that hopefully enable improved cell-based strategies for counteracting cancer and other diseases. |
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| Keywords: |
glycolysis; niche diversity; oxidative phosphorylation; phagocyte metabolism |
| College: |
Faculty of Medicine, Health and Life Sciences |
| Funders: |
National Cancer Institute
National Institutes of Health
Intramural Research Program, USA
Henry Wellcome Trust, UK. Grant Numbers: WT103973MA, 103973/Z/14/Z |
| Issue: |
1 |
| Start Page: |
37 |
| End Page: |
48 |