Journal article 112 views 3 downloads
Diversity and environmental adaptation of phagocytic cell metabolism
Journal of Leukocyte Biology, Volume: 105, Issue: 1, Pages: 37 - 48
Swansea University Author: Luke Davies
PDF | Version of Record
Copyright: 2018 The Authors. This is an open access article under the terms of the Creative Commons Attribution LicenseDownload (251.78KB)
DOI (Published version): 10.1002/jlb.4ri0518-195r
Phagocytes are cells of the immune system that play important roles in phagocytosis, respiratory burst and degranulation—key components of innate immunity and response to infection. This diverse group of cells includes monocytes, macrophages, dendritic cells, neutrophils, eosinophils, and basophils—...
|Published in:||Journal of Leukocyte Biology|
Check full text
No Tags, Be the first to tag this record!
Phagocytes are cells of the immune system that play important roles in phagocytosis, respiratory burst and degranulation—key components of innate immunity and response to infection. This diverse group of cells includes monocytes, macrophages, dendritic cells, neutrophils, eosinophils, and basophils—heterogeneous cell populations possessing cell and tissue-specific functions of which cellular metabolism comprises a critical underpinning. Core functions of phagocytic cells are diverse and sensitive to alterations in environmental- and tissue-specific nutrients and growth factors. As phagocytic cells adapt to these extracellular cues, cellular processes are altered and may contribute to pathogenesis. The considerable degree of functional heterogeneity among monocyte, neutrophil, and other phagocytic cell populations necessitates diverse metabolism. As we review our current understanding of metabolism in phagocytic cells, gaps are focused on to highlight the need for additional studies that hopefully enable improved cell-based strategies for counteracting cancer and other diseases.
glycolysis; niche diversity; oxidative phosphorylation; phagocyte metabolism
Faculty of Medicine, Health and Life Sciences
National Cancer Institute
National Institutes of Health
Intramural Research Program, USA
Henry Wellcome Trust, UK. Grant Numbers: WT103973MA, 103973/Z/14/Z