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Immune-metabolic adaptations in pregnancy: A potential stepping-stone to sepsis

Simran Sharma Orcid Logo, Patricia R.S. Rodrigues, Summia Zaher, Luke Davies Orcid Logo, Peter Ghazal Orcid Logo

eBioMedicine, Volume: 86, Start page: 104337

Swansea University Author: Luke Davies Orcid Logo

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Abstract

Physiological shifts during pregnancy predispose women to a higher risk of developing sepsis resulting from a maladapted host-response to infection. Insightful studies have delineated subtle point-changes to the immune system during pregnancy. Here, we present an overlay of these point-changes, aski...

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Published in: eBioMedicine
ISSN: 2352-3964
Published: Elsevier BV 2022
Online Access: Check full text

URI: https://cronfa.swan.ac.uk/Record/cronfa62112
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Abstract: Physiological shifts during pregnancy predispose women to a higher risk of developing sepsis resulting from a maladapted host-response to infection. Insightful studies have delineated subtle point-changes to the immune system during pregnancy. Here, we present an overlay of these point-changes, asking what changes and when, at a physiological, cellular, and molecular systems-level in the context of sepsis. We identify distinct immune phases in pregnancy delineated by placental hormone-driven changes in homeostasis setpoints of the immune and metabolic systems that subtly mirrors changes observed in sepsis. We propose that pregnancy immune-metabolic setpoint changes impact feedback thresholds that increase risk for a maladapted host-response to infection and thus act as a stepping-stone to sepsis. Defining maternal immune-metabolic setpoint changes is not only vital for tailoring the right diagnostic tools for early management of maternal sepsis but will facilitate an unravelling of the pathophysiological pathways that predispose an individual to sepsis.
Keywords: Pregnancy; Sepsis; Maternal sepsis; Maternity; Homeostasis; Metabolism; Immunity; Setpoint; Set-point change; Hormones; Vaccines
College: Faculty of Medicine, Health and Life Sciences
Funders: SS and SZ are funded by the Cardiff and Vale University Health Board, PG, LCD, PDSR are funded by the Project Sepsis Ser Cymru Programme from the Welsh Government/European Regional Development Fund.
Start Page: 104337