Immune-metabolic adaptations in pregnancy: A potential stepping-stone to sepsis

Sharma, Simran; Rodrigues, Patricia R.S.; Zaher, Summia; Davies, Luke; Ghazal, Peter

doi:10.1016/j.ebiom.2022.104337

Journal article 830 views 302 downloads

Immune-metabolic adaptations in pregnancy: A potential stepping-stone to sepsis

Simran Sharma

, Patricia R.S. Rodrigues, Summia Zaher, Luke Davies

, Peter Ghazal

eBioMedicine, Volume: 86, Start page: 104337

Swansea University Author: Luke Davies

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© 2022 Published by Elsevier B.V. This is an open access article under the CC BY-NC-ND license
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DOI (Published version): 10.1016/j.ebiom.2022.104337

Abstract

Physiological shifts during pregnancy predispose women to a higher risk of developing sepsis resulting from a maladapted host-response to infection. Insightful studies have delineated subtle point-changes to the immune system during pregnancy. Here, we present an overlay of these point-changes, aski...

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Published in:	eBioMedicine
ISSN:	2352-3964
Published:	Elsevier BV 2022
Online Access:	Check full text
URI:	https://cronfa.swan.ac.uk/Record/cronfa62112
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first_indexed	2023-01-09T16:52:27Z
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spelling	2023-01-09T16:54:14.8148938 v2 62112 2022-12-05 Immune-metabolic adaptations in pregnancy: A potential stepping-stone to sepsis ff080296775381560053d5e3a6e81745 0000-0001-7767-4060 Luke Davies Luke Davies true false 2022-12-05 BMS Physiological shifts during pregnancy predispose women to a higher risk of developing sepsis resulting from a maladapted host-response to infection. Insightful studies have delineated subtle point-changes to the immune system during pregnancy. Here, we present an overlay of these point-changes, asking what changes and when, at a physiological, cellular, and molecular systems-level in the context of sepsis. We identify distinct immune phases in pregnancy delineated by placental hormone-driven changes in homeostasis setpoints of the immune and metabolic systems that subtly mirrors changes observed in sepsis. We propose that pregnancy immune-metabolic setpoint changes impact feedback thresholds that increase risk for a maladapted host-response to infection and thus act as a stepping-stone to sepsis. Defining maternal immune-metabolic setpoint changes is not only vital for tailoring the right diagnostic tools for early management of maternal sepsis but will facilitate an unravelling of the pathophysiological pathways that predispose an individual to sepsis. Journal Article eBioMedicine 86 104337 Elsevier BV 2352-3964 Pregnancy; Sepsis; Maternal sepsis; Maternity; Homeostasis; Metabolism; Immunity; Setpoint; Set-point change; Hormones; Vaccines 2 12 2022 2022-12-02 10.1016/j.ebiom.2022.104337 COLLEGE NANME Biomedical Sciences COLLEGE CODE BMS Swansea University Another institution paid the OA fee SS and SZ are funded by the Cardiff and Vale University Health Board, PG, LCD, PDSR are funded by the Project Sepsis Ser Cymru Programme from the Welsh Government/European Regional Development Fund. 2023-01-09T16:54:14.8148938 2022-12-05T09:14:32.5404515 Faculty of Medicine, Health and Life Sciences Swansea University Medical School - Medicine Simran Sharma 0000-0002-6647-9355 1 Patricia R.S. Rodrigues 2 Summia Zaher 3 Luke Davies 0000-0001-7767-4060 4 Peter Ghazal 0000-0003-0035-2228 5 62112__26218__1063398e32e04af6b6fa0c44c3d28818.pdf 62112.pdf 2023-01-09T16:52:54.3929363 Output 1391917 application/pdf Version of Record true © 2022 Published by Elsevier B.V. This is an open access article under the CC BY-NC-ND license true eng http://creativecommons.org/licenses/by-nc-nd/4.0/
title	Immune-metabolic adaptations in pregnancy: A potential stepping-stone to sepsis
spellingShingle	Immune-metabolic adaptations in pregnancy: A potential stepping-stone to sepsis Luke Davies
title_short	Immune-metabolic adaptations in pregnancy: A potential stepping-stone to sepsis
title_full	Immune-metabolic adaptations in pregnancy: A potential stepping-stone to sepsis
title_fullStr	Immune-metabolic adaptations in pregnancy: A potential stepping-stone to sepsis
title_full_unstemmed	Immune-metabolic adaptations in pregnancy: A potential stepping-stone to sepsis
title_sort	Immune-metabolic adaptations in pregnancy: A potential stepping-stone to sepsis
author_id_str_mv	ff080296775381560053d5e3a6e81745
author_id_fullname_str_mv	ff080296775381560053d5e3a6e81745_***_Luke Davies
author	Luke Davies
author2	Simran Sharma Patricia R.S. Rodrigues Summia Zaher Luke Davies Peter Ghazal
format	Journal article
container_title	eBioMedicine
container_volume	86
container_start_page	104337
publishDate	2022
institution	Swansea University
issn	2352-3964
doi_str_mv	10.1016/j.ebiom.2022.104337
publisher	Elsevier BV
college_str	Faculty of Medicine, Health and Life Sciences
hierarchytype
hierarchy_top_id	facultyofmedicinehealthandlifesciences
hierarchy_top_title	Faculty of Medicine, Health and Life Sciences
hierarchy_parent_id	facultyofmedicinehealthandlifesciences
hierarchy_parent_title	Faculty of Medicine, Health and Life Sciences
department_str	Swansea University Medical School - Medicine{{{_:::_}}}Faculty of Medicine, Health and Life Sciences{{{_:::_}}}Swansea University Medical School - Medicine
document_store_str	1
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description	Physiological shifts during pregnancy predispose women to a higher risk of developing sepsis resulting from a maladapted host-response to infection. Insightful studies have delineated subtle point-changes to the immune system during pregnancy. Here, we present an overlay of these point-changes, asking what changes and when, at a physiological, cellular, and molecular systems-level in the context of sepsis. We identify distinct immune phases in pregnancy delineated by placental hormone-driven changes in homeostasis setpoints of the immune and metabolic systems that subtly mirrors changes observed in sepsis. We propose that pregnancy immune-metabolic setpoint changes impact feedback thresholds that increase risk for a maladapted host-response to infection and thus act as a stepping-stone to sepsis. Defining maternal immune-metabolic setpoint changes is not only vital for tailoring the right diagnostic tools for early management of maternal sepsis but will facilitate an unravelling of the pathophysiological pathways that predispose an individual to sepsis.
published_date	2022-12-02T04:21:29Z
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Immune-metabolic adaptations in pregnancy: A potential stepping-stone to sepsis

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