Diversity and environmental adaptation of phagocytic cell metabolism

Davies, Luke; Rice, Christopher M.; McVicar, Daniel W.; Weiss, Jonathan M.

doi:10.1002/jlb.4ri0518-195r

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Diversity and environmental adaptation of phagocytic cell metabolism

Luke Davies

, Christopher M. Rice, Daniel W. McVicar, Jonathan M. Weiss

Journal of Leukocyte Biology, Volume: 105, Issue: 1, Pages: 37 - 48

Swansea University Author: Luke Davies

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Copyright: 2018 The Authors. This is an open access article under the terms of the Creative Commons Attribution License
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DOI (Published version): 10.1002/jlb.4ri0518-195r

Abstract

Phagocytes are cells of the immune system that play important roles in phagocytosis, respiratory burst and degranulation—key components of innate immunity and response to infection. This diverse group of cells includes monocytes, macrophages, dendritic cells, neutrophils, eosinophils, and basophils—...

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Published in:	Journal of Leukocyte Biology
ISSN:	0741-5400 1938-3673
Published:	Wiley 2019
Online Access:	Check full text
URI:	https://cronfa.swan.ac.uk/Record/cronfa61699
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first_indexed	2022-11-07T13:38:32Z
last_indexed	2023-01-13T19:22:37Z
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spelling	2022-11-07T13:42:54.3848969 v2 61699 2022-10-31 Diversity and environmental adaptation of phagocytic cell metabolism ff080296775381560053d5e3a6e81745 0000-0001-7767-4060 Luke Davies Luke Davies true false 2022-10-31 BMS Phagocytes are cells of the immune system that play important roles in phagocytosis, respiratory burst and degranulation—key components of innate immunity and response to infection. This diverse group of cells includes monocytes, macrophages, dendritic cells, neutrophils, eosinophils, and basophils—heterogeneous cell populations possessing cell and tissue-specific functions of which cellular metabolism comprises a critical underpinning. Core functions of phagocytic cells are diverse and sensitive to alterations in environmental- and tissue-specific nutrients and growth factors. As phagocytic cells adapt to these extracellular cues, cellular processes are altered and may contribute to pathogenesis. The considerable degree of functional heterogeneity among monocyte, neutrophil, and other phagocytic cell populations necessitates diverse metabolism. As we review our current understanding of metabolism in phagocytic cells, gaps are focused on to highlight the need for additional studies that hopefully enable improved cell-based strategies for counteracting cancer and other diseases. Journal Article Journal of Leukocyte Biology 105 1 37 48 Wiley 0741-5400 1938-3673 glycolysis; niche diversity; oxidative phosphorylation; phagocyte metabolism 1 1 2019 2019-01-01 10.1002/jlb.4ri0518-195r COLLEGE NANME Biomedical Sciences COLLEGE CODE BMS Swansea University National Cancer Institute National Institutes of Health Intramural Research Program, USA Henry Wellcome Trust, UK. Grant Numbers: WT103973MA, 103973/Z/14/Z 2022-11-07T13:42:54.3848969 2022-10-31T12:38:34.5569760 Faculty of Medicine, Health and Life Sciences Swansea University Medical School - Medicine Luke Davies 0000-0001-7767-4060 1 Christopher M. Rice 2 Daniel W. McVicar 3 Jonathan M. Weiss 4 61699__25669__dd2ae2480bcf4d09a979aab7ddac9750.pdf 61699.pdf 2022-11-07T13:39:46.2203699 Output 257821 application/pdf Version of Record true Copyright: 2018 The Authors. This is an open access article under the terms of the Creative Commons Attribution License true eng http://creativecommons.org/licenses/by/4.0/
title	Diversity and environmental adaptation of phagocytic cell metabolism
spellingShingle	Diversity and environmental adaptation of phagocytic cell metabolism Luke Davies
title_short	Diversity and environmental adaptation of phagocytic cell metabolism
title_full	Diversity and environmental adaptation of phagocytic cell metabolism
title_fullStr	Diversity and environmental adaptation of phagocytic cell metabolism
title_full_unstemmed	Diversity and environmental adaptation of phagocytic cell metabolism
title_sort	Diversity and environmental adaptation of phagocytic cell metabolism
author_id_str_mv	ff080296775381560053d5e3a6e81745
author_id_fullname_str_mv	ff080296775381560053d5e3a6e81745_***_Luke Davies
author	Luke Davies
author2	Luke Davies Christopher M. Rice Daniel W. McVicar Jonathan M. Weiss
format	Journal article
container_title	Journal of Leukocyte Biology
container_volume	105
container_issue	1
container_start_page	37
publishDate	2019
institution	Swansea University
issn	0741-5400 1938-3673
doi_str_mv	10.1002/jlb.4ri0518-195r
publisher	Wiley
college_str	Faculty of Medicine, Health and Life Sciences
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hierarchy_top_title	Faculty of Medicine, Health and Life Sciences
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hierarchy_parent_title	Faculty of Medicine, Health and Life Sciences
department_str	Swansea University Medical School - Medicine{{{_:::_}}}Faculty of Medicine, Health and Life Sciences{{{_:::_}}}Swansea University Medical School - Medicine
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description	Phagocytes are cells of the immune system that play important roles in phagocytosis, respiratory burst and degranulation—key components of innate immunity and response to infection. This diverse group of cells includes monocytes, macrophages, dendritic cells, neutrophils, eosinophils, and basophils—heterogeneous cell populations possessing cell and tissue-specific functions of which cellular metabolism comprises a critical underpinning. Core functions of phagocytic cells are diverse and sensitive to alterations in environmental- and tissue-specific nutrients and growth factors. As phagocytic cells adapt to these extracellular cues, cellular processes are altered and may contribute to pathogenesis. The considerable degree of functional heterogeneity among monocyte, neutrophil, and other phagocytic cell populations necessitates diverse metabolism. As we review our current understanding of metabolism in phagocytic cells, gaps are focused on to highlight the need for additional studies that hopefully enable improved cell-based strategies for counteracting cancer and other diseases.
published_date	2019-01-01T04:20:42Z
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score	11.03559

Diversity and environmental adaptation of phagocytic cell metabolism

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