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The Production and Electrospinning Application of Novel Collagen Materials / KIRAN MISTRY

Swansea University Author: KIRAN MISTRY

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Abstract

Arthritis affects millions of people worldwide. Deteriorating the smooth cartilage layer and causing repeat build of scar tissue and subsequent breakdown. Collagen is the main biological material that forms the extra cellular matrix of cartilage and provides its strength. Electrospinning is a versat...

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Published: Swansea, Wales, UK 2023
Institution: Swansea University
Degree level: Master of Research
Degree name: MSc by Research
Supervisor: Wright, Chris.
URI: https://cronfa.swan.ac.uk/Record/cronfa63679
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Abstract: Arthritis affects millions of people worldwide. Deteriorating the smooth cartilage layer and causing repeat build of scar tissue and subsequent breakdown. Collagen is the main biological material that forms the extra cellular matrix of cartilage and provides its strength. Electrospinning is a versatile technique and highly adjustable which is why it has seen a rise in popularity. The use of collagen in tissue engineering in order to produce scaffolds has been widely explored with great strides in collagen blends and application. However, they all suffer from the use of harsh solvents such as 1,1,1,3,3,3-Hexafluoro-2-Propanol (HFP) or 2,2,2-trifluoroethanol (TFE), which denature collagen into gelatine, which has none of the favourable characteristics of collagen. In this study, it has been determined that a neutral solvent, PBS can be used and mixed with Single Alpha-Chain Jellyfish collagen to produce electrospun fibres with an average of 0.759μm in diameter using the electrospinning technique. With the process parameters of 20 kV, 0.05 ml/hr flow rate and a distance between collector and tip of 16 cm.
Keywords: Medical Engineering, Collagen, Electrospinning
College: Faculty of Science and Engineering

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