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The Production and Electrospinning Application of Novel Collagen Materials / KIRAN MISTRY

Swansea University Author: KIRAN MISTRY

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Abstract

Arthritis affects millions of people worldwide. Deteriorating the smooth cartilage layer and causing repeat build of scar tissue and subsequent breakdown. Collagen is the main biological material that forms the extra cellular matrix of cartilage and provides its strength. Electrospinning is a versat...

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Published: Swansea, Wales, UK 2023
Institution: Swansea University
Degree level: Master of Research
Degree name: MSc by Research
Supervisor: Wright, Chris.
URI: https://cronfa.swan.ac.uk/Record/cronfa63679
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first_indexed 2023-06-21T14:14:07Z
last_indexed 2023-06-21T14:14:07Z
id cronfa63679
recordtype RisThesis
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spelling v2 63679 2023-06-21 The Production and Electrospinning Application of Novel Collagen Materials fb7b10c36fdcaf851a64e4e4d6bae043 KIRAN MISTRY KIRAN MISTRY true false 2023-06-21 Arthritis affects millions of people worldwide. Deteriorating the smooth cartilage layer and causing repeat build of scar tissue and subsequent breakdown. Collagen is the main biological material that forms the extra cellular matrix of cartilage and provides its strength. Electrospinning is a versatile technique and highly adjustable which is why it has seen a rise in popularity. The use of collagen in tissue engineering in order to produce scaffolds has been widely explored with great strides in collagen blends and application. However, they all suffer from the use of harsh solvents such as 1,1,1,3,3,3-Hexafluoro-2-Propanol (HFP) or 2,2,2-trifluoroethanol (TFE), which denature collagen into gelatine, which has none of the favourable characteristics of collagen. In this study, it has been determined that a neutral solvent, PBS can be used and mixed with Single Alpha-Chain Jellyfish collagen to produce electrospun fibres with an average of 0.759μm in diameter using the electrospinning technique. With the process parameters of 20 kV, 0.05 ml/hr flow rate and a distance between collector and tip of 16 cm. E-Thesis Swansea, Wales, UK Medical Engineering, Collagen, Electrospinning 24 5 2023 2023-05-24 COLLEGE NANME COLLEGE CODE Swansea University Wright, Chris. Master of Research MSc by Research 2023-06-21T15:16:49.4314732 2023-06-21T15:11:49.4643343 Faculty of Science and Engineering School of Engineering and Applied Sciences - Biomedical Engineering KIRAN MISTRY 1 63679__27921__91f48a4eb95f4e7e8022bec388d7a171.pdf 2023_Mistry_K.final.63679.pdf 2023-06-21T15:14:59.0006149 Output 2337352 application/pdf E-Thesis – open access true Copyright: The Author, Kiran Mistry, 2023. Distributed under the terms of a Creative Commons Attribution 4.0 License (CC BY 4.0). true eng https://creativecommons.org/licenses/by/4.0/
title The Production and Electrospinning Application of Novel Collagen Materials
spellingShingle The Production and Electrospinning Application of Novel Collagen Materials
KIRAN MISTRY
title_short The Production and Electrospinning Application of Novel Collagen Materials
title_full The Production and Electrospinning Application of Novel Collagen Materials
title_fullStr The Production and Electrospinning Application of Novel Collagen Materials
title_full_unstemmed The Production and Electrospinning Application of Novel Collagen Materials
title_sort The Production and Electrospinning Application of Novel Collagen Materials
author_id_str_mv fb7b10c36fdcaf851a64e4e4d6bae043
author_id_fullname_str_mv fb7b10c36fdcaf851a64e4e4d6bae043_***_KIRAN MISTRY
author KIRAN MISTRY
author2 KIRAN MISTRY
format E-Thesis
publishDate 2023
institution Swansea University
college_str Faculty of Science and Engineering
hierarchytype
hierarchy_top_id facultyofscienceandengineering
hierarchy_top_title Faculty of Science and Engineering
hierarchy_parent_id facultyofscienceandengineering
hierarchy_parent_title Faculty of Science and Engineering
department_str School of Engineering and Applied Sciences - Biomedical Engineering{{{_:::_}}}Faculty of Science and Engineering{{{_:::_}}}School of Engineering and Applied Sciences - Biomedical Engineering
document_store_str 1
active_str 0
description Arthritis affects millions of people worldwide. Deteriorating the smooth cartilage layer and causing repeat build of scar tissue and subsequent breakdown. Collagen is the main biological material that forms the extra cellular matrix of cartilage and provides its strength. Electrospinning is a versatile technique and highly adjustable which is why it has seen a rise in popularity. The use of collagen in tissue engineering in order to produce scaffolds has been widely explored with great strides in collagen blends and application. However, they all suffer from the use of harsh solvents such as 1,1,1,3,3,3-Hexafluoro-2-Propanol (HFP) or 2,2,2-trifluoroethanol (TFE), which denature collagen into gelatine, which has none of the favourable characteristics of collagen. In this study, it has been determined that a neutral solvent, PBS can be used and mixed with Single Alpha-Chain Jellyfish collagen to produce electrospun fibres with an average of 0.759μm in diameter using the electrospinning technique. With the process parameters of 20 kV, 0.05 ml/hr flow rate and a distance between collector and tip of 16 cm.
published_date 2023-05-24T15:16:49Z
_version_ 1769322063816818688
score 11.01628

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