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Exercise training induces thrombogenic benefits in recent but not late postmenopausal women

Line Boel Nørregaard, Kate Aiko Wickham, Thomas Ehlers, Marcos Paulo Rocha, Mads Fischer, Martina H. Lundberg Slingsby, Stephen S. Cheung, Adrian Evans, Jens Bangsbo

American Journal of Physiology-Heart and Circulatory Physiology, Volume: 325, Issue: 2, Pages: H346 - H361

Swansea University Author: Adrian Evans

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DOI (Published version): 10.1152/ajpheart.00054.2023

Abstract

Although regular physical activity is known to improve cardiovascular health in men, evidence for its beneficial effects in postmenopausal females is less convincing and it remains unclear whether initiation of exercise training soon after, rather than manyyears after menopause impacts the magnitude...

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Published in: American Journal of Physiology-Heart and Circulatory Physiology
ISSN: 0363-6135 1522-1539
Published: American Physiological Society 2023
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URI: https://cronfa.swan.ac.uk/Record/cronfa63903
first_indexed 2023-08-10T13:58:50Z
last_indexed 2024-11-25T14:13:05Z
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We evaluated exercise-induced changes inmarkers of thrombotic risk and conduit artery function in recent5yr compared with late10yr postmenopausal females. Fourteenrecent5yr and 13 late10yr healthy postmenopausal females completed 8 wk of regular intensive exercise training, consisting offloorball and cycling. Markers of thrombotic risk and vascular health were assessed before and after the intervention, and datawere analyzed using a linear mixed model. Exercise training reduced markers of thrombotic risk, including an 11% reduction (P &#xBC;0.007) in agonist-induced platelet reactivity and a reduction (P &#xBC; 0.027) in incipient clot microstructure (40% reduction in clotmass) in the recent5yr but not the late10yr (P &#xBC; 0.380; P &#xBC; 0.739, respectively) postmenopausal females. There was no changein conduit artery function, as measured by brachial (recent5yr, P &#xBC; 0.804; late10yr, P &#xBC; 0.311) and popliteal artery (recent5yr,P &#xBC; 0.130; late10yr, P &#xBC; 0.434) flow-mediated dilation. Only the late10yr postmenopausal females exhibited an increase (by9.6%, P &#xBC; 0.022) in intracellular adhesion molecule-1 levels after training, which may have impacted the thrombogenic adaptation in this group. These findings suggest that 8 wk of high-intensity exercise training reduces thrombotic risk in recent5yr, butnot late10yr postmenopausal females. Thus, regular physical activity initiated soon after, rather than many years after menopause and at a higher age, may be more efficient for reducing thrombogenic risk.NEW &amp;amp; NOTEWORTHY Eight weeks of high-intensity exercise training reduces platelet reactivity as well as blood clot densityand strength in females 5 yr past menopause but not in females 10 yr past menopause. The divergent response in the latepostmenopausal females may be explained by training-induced low-grade systemic inflammation. 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Lundberg</firstname><surname>Slingsby</surname><order>6</order></author><author><firstname>Stephen S.</firstname><surname>Cheung</surname><order>7</order></author><author><firstname>Adrian</firstname><surname>Evans</surname><order>8</order></author><author><firstname>Jens</firstname><surname>Bangsbo</surname><order>9</order></author></authors><documents/><OutputDurs/></rfc1807>
spelling 2023-10-03T12:22:34.4069890 v2 63903 2023-07-17 Exercise training induces thrombogenic benefits in recent but not late postmenopausal women 21761f6eb805546a561c9f036e85405b Adrian Evans Adrian Evans true false 2023-07-17 Although regular physical activity is known to improve cardiovascular health in men, evidence for its beneficial effects in postmenopausal females is less convincing and it remains unclear whether initiation of exercise training soon after, rather than manyyears after menopause impacts the magnitude of training-induced adaptations. We evaluated exercise-induced changes inmarkers of thrombotic risk and conduit artery function in recent5yr compared with late10yr postmenopausal females. Fourteenrecent5yr and 13 late10yr healthy postmenopausal females completed 8 wk of regular intensive exercise training, consisting offloorball and cycling. Markers of thrombotic risk and vascular health were assessed before and after the intervention, and datawere analyzed using a linear mixed model. Exercise training reduced markers of thrombotic risk, including an 11% reduction (P ¼0.007) in agonist-induced platelet reactivity and a reduction (P ¼ 0.027) in incipient clot microstructure (40% reduction in clotmass) in the recent5yr but not the late10yr (P ¼ 0.380; P ¼ 0.739, respectively) postmenopausal females. There was no changein conduit artery function, as measured by brachial (recent5yr, P ¼ 0.804; late10yr, P ¼ 0.311) and popliteal artery (recent5yr,P ¼ 0.130; late10yr, P ¼ 0.434) flow-mediated dilation. Only the late10yr postmenopausal females exhibited an increase (by9.6%, P ¼ 0.022) in intracellular adhesion molecule-1 levels after training, which may have impacted the thrombogenic adaptation in this group. These findings suggest that 8 wk of high-intensity exercise training reduces thrombotic risk in recent5yr, butnot late10yr postmenopausal females. Thus, regular physical activity initiated soon after, rather than many years after menopause and at a higher age, may be more efficient for reducing thrombogenic risk.NEW &amp; NOTEWORTHY Eight weeks of high-intensity exercise training reduces platelet reactivity as well as blood clot densityand strength in females 5 yr past menopause but not in females 10 yr past menopause. The divergent response in the latepostmenopausal females may be explained by training-induced low-grade systemic inflammation. These findings suggest thatregular physical activity initiated soon after menopause, compared with many years after menopause, may be more efficient forreducing the risk of blood clots. Journal Article American Journal of Physiology-Heart and Circulatory Physiology 325 2 H346 H361 American Physiological Society 0363-6135 1522-1539 Exercise training; menopause; platelets; thrombosis; vascular function 31 8 2023 2023-08-31 10.1152/ajpheart.00054.2023 http://dx.doi.org/10.1152/ajpheart.00054.2023 COLLEGE NANME COLLEGE CODE Swansea University Not Required Nordea Foundation, Helsefonden; the Danish Ministry of Culture Fund for Sports Research 2023-10-03T12:22:34.4069890 2023-07-17T15:28:25.6593730 Faculty of Medicine, Health and Life Sciences Swansea University Medical School - Medicine Line Boel Nørregaard 1 Kate Aiko Wickham 2 Thomas Ehlers 3 Marcos Paulo Rocha 4 Mads Fischer 5 Martina H. Lundberg Slingsby 6 Stephen S. Cheung 7 Adrian Evans 8 Jens Bangsbo 9
title Exercise training induces thrombogenic benefits in recent but not late postmenopausal women
spellingShingle Exercise training induces thrombogenic benefits in recent but not late postmenopausal women
Adrian Evans
title_short Exercise training induces thrombogenic benefits in recent but not late postmenopausal women
title_full Exercise training induces thrombogenic benefits in recent but not late postmenopausal women
title_fullStr Exercise training induces thrombogenic benefits in recent but not late postmenopausal women
title_full_unstemmed Exercise training induces thrombogenic benefits in recent but not late postmenopausal women
title_sort Exercise training induces thrombogenic benefits in recent but not late postmenopausal women
author_id_str_mv 21761f6eb805546a561c9f036e85405b
author_id_fullname_str_mv 21761f6eb805546a561c9f036e85405b_***_Adrian Evans
author Adrian Evans
author2 Line Boel Nørregaard
Kate Aiko Wickham
Thomas Ehlers
Marcos Paulo Rocha
Mads Fischer
Martina H. Lundberg Slingsby
Stephen S. Cheung
Adrian Evans
Jens Bangsbo
format Journal article
container_title American Journal of Physiology-Heart and Circulatory Physiology
container_volume 325
container_issue 2
container_start_page H346
publishDate 2023
institution Swansea University
issn 0363-6135
1522-1539
doi_str_mv 10.1152/ajpheart.00054.2023
publisher American Physiological Society
college_str Faculty of Medicine, Health and Life Sciences
hierarchytype
hierarchy_top_id facultyofmedicinehealthandlifesciences
hierarchy_top_title Faculty of Medicine, Health and Life Sciences
hierarchy_parent_id facultyofmedicinehealthandlifesciences
hierarchy_parent_title Faculty of Medicine, Health and Life Sciences
department_str Swansea University Medical School - Medicine{{{_:::_}}}Faculty of Medicine, Health and Life Sciences{{{_:::_}}}Swansea University Medical School - Medicine
url http://dx.doi.org/10.1152/ajpheart.00054.2023
document_store_str 0
active_str 0
description Although regular physical activity is known to improve cardiovascular health in men, evidence for its beneficial effects in postmenopausal females is less convincing and it remains unclear whether initiation of exercise training soon after, rather than manyyears after menopause impacts the magnitude of training-induced adaptations. We evaluated exercise-induced changes inmarkers of thrombotic risk and conduit artery function in recent5yr compared with late10yr postmenopausal females. Fourteenrecent5yr and 13 late10yr healthy postmenopausal females completed 8 wk of regular intensive exercise training, consisting offloorball and cycling. Markers of thrombotic risk and vascular health were assessed before and after the intervention, and datawere analyzed using a linear mixed model. Exercise training reduced markers of thrombotic risk, including an 11% reduction (P ¼0.007) in agonist-induced platelet reactivity and a reduction (P ¼ 0.027) in incipient clot microstructure (40% reduction in clotmass) in the recent5yr but not the late10yr (P ¼ 0.380; P ¼ 0.739, respectively) postmenopausal females. There was no changein conduit artery function, as measured by brachial (recent5yr, P ¼ 0.804; late10yr, P ¼ 0.311) and popliteal artery (recent5yr,P ¼ 0.130; late10yr, P ¼ 0.434) flow-mediated dilation. Only the late10yr postmenopausal females exhibited an increase (by9.6%, P ¼ 0.022) in intracellular adhesion molecule-1 levels after training, which may have impacted the thrombogenic adaptation in this group. These findings suggest that 8 wk of high-intensity exercise training reduces thrombotic risk in recent5yr, butnot late10yr postmenopausal females. Thus, regular physical activity initiated soon after, rather than many years after menopause and at a higher age, may be more efficient for reducing thrombogenic risk.NEW &amp; NOTEWORTHY Eight weeks of high-intensity exercise training reduces platelet reactivity as well as blood clot densityand strength in females 5 yr past menopause but not in females 10 yr past menopause. The divergent response in the latepostmenopausal females may be explained by training-induced low-grade systemic inflammation. These findings suggest thatregular physical activity initiated soon after menopause, compared with many years after menopause, may be more efficient forreducing the risk of blood clots.
published_date 2023-08-31T08:11:02Z
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score 11.048994

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