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Uptake of COVID-19 vaccinations amongst 3,433,483 children and young people: meta-analysis of UK prospective cohorts
Nature Communications, Volume: 15, Issue: 1
Swansea University Authors:
Sarah Aldridge, Ashley Akbari , Stuart Bedston, Rowena Griffiths, Emily Lowthian
, Ronan Lyons
, Rhiannon Owen
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DOI (Published version): 10.1038/s41467-024-46451-0
Abstract
SARS-CoV-2 infection in children and young people (CYP) can lead to life-threatening COVID-19, transmission within households and schools, and the development of long COVID. Using linked health and administrative data, we investigated vaccine uptake among 3,433,483 CYP aged 5–17 years across all UK...
Published in: | Nature Communications |
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ISSN: | 2041-1723 |
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Springer Science and Business Media LLC
2024
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Using linked health and administrative data, we investigated vaccine uptake among 3,433,483 CYP aged 5–17 years across all UK nations between 4th August 2021 and 31st May 2022. We constructed national cohorts and undertook multi-state modelling and meta-analysis to identify associations between demographic variables and vaccine uptake. We found that uptake of the first COVID-19 vaccine among CYP was low across all four nations compared to other age groups and diminished with subsequent doses. Age and vaccination status of adults living in the same household were identified as important risk factors associated with vaccine uptake in CYP. For example, 5–11 year-olds were less likely to receive their first vaccine compared to 16–17 year-olds (adjusted Hazard Ratio [aHR]: 0.10 (95%CI: 0.06–0.19)), and CYP in unvaccinated households were less likely to receive their first vaccine compared to CYP in partially vaccinated households (aHR: 0.19, 95%CI 0.13–0.29).</abstract><type>Journal Article</type><journal>Nature Communications</journal><volume>15</volume><journalNumber>1</journalNumber><paginationStart/><paginationEnd/><publisher>Springer Science and Business Media LLC</publisher><placeOfPublication/><isbnPrint/><isbnElectronic/><issnPrint/><issnElectronic>2041-1723</issnElectronic><keywords>Epidemiology, Health policy, preventative medicine, SARS-Cov-2</keywords><publishedDay>15</publishedDay><publishedMonth>3</publishedMonth><publishedYear>2024</publishedYear><publishedDate>2024-03-15</publishedDate><doi>10.1038/s41467-024-46451-0</doi><url/><notes/><college>COLLEGE NANME</college><department>Medical School</department><CollegeCode>COLLEGE CODE</CollegeCode><DepartmentCode>MEDS</DepartmentCode><institution>Swansea University</institution><apcterm>External research funder(s) paid the OA fee (includes OA grants disbursed by the Library)</apcterm><funders>This research is part of the Data and Connectivity National Core Study, led by Health Data Research (HDR) UK in partnership with the Office for National Statistics and funded by UK Research and Innovation (grant ref MC_PC_20058) [UA, SM, AA, SB, MJ, EL, SL, CR, DB, RAL, AS]. Data and Connectivity: COVID-19 Vaccines Pharmacovigilance National Core Study - Uptake, safety and effectiveness of COVID-19 vaccines in: pregnancy; children and young people; those receiving booster doses; and disease caused by different variants (2021.0158) [UA, SM, AA, SB, MJ, SL, LP, CR, DB, RAL, AS, RKO] is a partnership between University of Edinburgh, University of Oxford, University of Strathclyde, Queen’s University Belfast, Swansea University, Imperial College London and the Office for National Statistics. This partnership was funded by HDR UK and The Alan Turing Institute. RKO is supported by the Academy of Medical Sciences/the Wellcome Trust/ the Government Department of Business, Energy and Industrial Strategy/the British Heart Foundation/Diabetes UK Springboard Award (SBF006\1122). This work was supported by HDR UK, which receives its funding from HDR UK Ltd (HDR-9006) [SA, AA, SB, RGr, EL, RAL, RKO], funded by the UK Medical Research Council, Engineering and Physical Sciences Research Council, Economic and Social Research Council, Department of Health and Social Care (England), Chief Scientist Office of the Scottish Government Health and Social Care Directorates, Health and Social Care Research and Development Division (Welsh Government), Public Health Agency (Northern Ireland), British Heart Foundation (BHF) and the Wellcome Trust. This work was supported by the Administrative Data Research (ADR) Wales programme of work. ADR Wales, part of the ADR UK investment, unites research expertise from Swansea University Medical School and WISERD (Wales Institute of Social and Economic Research and Data) at Cardiff University with analysts from Welsh Government. ADR UK is funded by the Economic and Social Research Council (ESRC), part of UK Research and Innovation. This research was supported by ESRC funding, including Administrative Data Research Wales (ES/W012227/1) [AA, SB, RAL]. Additionally the authors acknowledge the support of BREATHE—The Health Data Research Hub for Respiratory Health (MC_PC_19004) [AS], which is funded through the UK Research and Innovation Industrial Strategy Challenge Fund and delivered through Health Data Research UK. This work was also supported by the Con-COV team funded by the Medical Research Council (grant number: MR/V028367/1) [AA, RAL].</funders><projectreference/><lastEdited>2024-07-15T11:47:13.1252678</lastEdited><Created>2024-03-17T17:35:23.8691718</Created><path><level id="1">Faculty of Medicine, Health and Life Sciences</level><level id="2">Swansea University Medical School - Health Data Science</level></path><authors><author><firstname>Sarah</firstname><surname>Aldridge</surname><order>1</order></author><author><firstname>Utkarsh</firstname><surname>Agrawal</surname><order>2</order></author><author><firstname>Siobhán</firstname><surname>Murphy</surname><order>3</order></author><author><firstname>Tristan</firstname><surname>Millington</surname><order>4</order></author><author><firstname>Ashley</firstname><surname>Akbari</surname><orcid>0000-0003-0814-0801</orcid><order>5</order></author><author><firstname>Fatima</firstname><surname>Almaghrabi</surname><order>6</order></author><author><firstname>Sneha N.</firstname><surname>Anand</surname><order>7</order></author><author><firstname>Stuart</firstname><surname>Bedston</surname><order>8</order></author><author><firstname>Rosalind</firstname><surname>Goudie</surname><order>9</order></author><author><firstname>Rowena</firstname><surname>Griffiths</surname><order>10</order></author><author><firstname>Mark</firstname><surname>Joy</surname><order>11</order></author><author><firstname>Emily</firstname><surname>Lowthian</surname><orcid>0000-0001-9362-0046</orcid><order>12</order></author><author><firstname>Simon de</firstname><surname>Lusignan</surname><orcid>0000-0002-8553-2641</orcid><order>13</order></author><author><firstname>Lynsey</firstname><surname>Patterson</surname><order>14</order></author><author><firstname>Chris</firstname><surname>Robertson</surname><orcid>0000-0001-6848-5241</orcid><order>15</order></author><author><firstname>Igor</firstname><surname>Rudan</surname><order>16</order></author><author><firstname>Declan T.</firstname><surname>Bradley</surname><orcid>0000-0003-1468-1823</orcid><order>17</order></author><author><firstname>Ronan</firstname><surname>Lyons</surname><orcid>0000-0001-5225-000X</orcid><order>18</order></author><author><firstname>Aziz</firstname><surname>Sheikh</surname><order>19</order></author><author><firstname>Rhiannon</firstname><surname>Owen</surname><orcid>0000-0001-5977-376X</orcid><order>20</order></author></authors><documents><document><filename>65851__29798__113a842c601d4a239cefc5f9b342d575.pdf</filename><originalFilename>65851.VOR.pdf</originalFilename><uploaded>2024-03-22T11:20:38.7793310</uploaded><type>Output</type><contentLength>2127715</contentLength><contentType>application/pdf</contentType><version>Version of Record</version><cronfaStatus>true</cronfaStatus><documentNotes>This article is licensed under a Creative Commons
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v2 65851 2024-03-17 Uptake of COVID-19 vaccinations amongst 3,433,483 children and young people: meta-analysis of UK prospective cohorts a42ee8ba1ff8174d5bb62d2d95364b90 Sarah Aldridge Sarah Aldridge true false aa1b025ec0243f708bb5eb0a93d6fb52 0000-0003-0814-0801 Ashley Akbari Ashley Akbari true false c79d07eaba5c9515c0df82b372b76a41 Stuart Bedston Stuart Bedston true false 381464f639f98bd388c29326ca7f862c Rowena Griffiths Rowena Griffiths true false db5bc529b8a9dfca2b4a268d14e03479 0000-0001-9362-0046 Emily Lowthian Emily Lowthian true false 83efcf2a9dfcf8b55586999d3d152ac6 0000-0001-5225-000X Ronan Lyons Ronan Lyons true false 0d30aa00eef6528f763a1e1589f703ec 0000-0001-5977-376X Rhiannon Owen Rhiannon Owen true false 2024-03-17 MEDS SARS-CoV-2 infection in children and young people (CYP) can lead to life-threatening COVID-19, transmission within households and schools, and the development of long COVID. Using linked health and administrative data, we investigated vaccine uptake among 3,433,483 CYP aged 5–17 years across all UK nations between 4th August 2021 and 31st May 2022. We constructed national cohorts and undertook multi-state modelling and meta-analysis to identify associations between demographic variables and vaccine uptake. We found that uptake of the first COVID-19 vaccine among CYP was low across all four nations compared to other age groups and diminished with subsequent doses. Age and vaccination status of adults living in the same household were identified as important risk factors associated with vaccine uptake in CYP. For example, 5–11 year-olds were less likely to receive their first vaccine compared to 16–17 year-olds (adjusted Hazard Ratio [aHR]: 0.10 (95%CI: 0.06–0.19)), and CYP in unvaccinated households were less likely to receive their first vaccine compared to CYP in partially vaccinated households (aHR: 0.19, 95%CI 0.13–0.29). Journal Article Nature Communications 15 1 Springer Science and Business Media LLC 2041-1723 Epidemiology, Health policy, preventative medicine, SARS-Cov-2 15 3 2024 2024-03-15 10.1038/s41467-024-46451-0 COLLEGE NANME Medical School COLLEGE CODE MEDS Swansea University External research funder(s) paid the OA fee (includes OA grants disbursed by the Library) This research is part of the Data and Connectivity National Core Study, led by Health Data Research (HDR) UK in partnership with the Office for National Statistics and funded by UK Research and Innovation (grant ref MC_PC_20058) [UA, SM, AA, SB, MJ, EL, SL, CR, DB, RAL, AS]. Data and Connectivity: COVID-19 Vaccines Pharmacovigilance National Core Study - Uptake, safety and effectiveness of COVID-19 vaccines in: pregnancy; children and young people; those receiving booster doses; and disease caused by different variants (2021.0158) [UA, SM, AA, SB, MJ, SL, LP, CR, DB, RAL, AS, RKO] is a partnership between University of Edinburgh, University of Oxford, University of Strathclyde, Queen’s University Belfast, Swansea University, Imperial College London and the Office for National Statistics. This partnership was funded by HDR UK and The Alan Turing Institute. RKO is supported by the Academy of Medical Sciences/the Wellcome Trust/ the Government Department of Business, Energy and Industrial Strategy/the British Heart Foundation/Diabetes UK Springboard Award (SBF006\1122). This work was supported by HDR UK, which receives its funding from HDR UK Ltd (HDR-9006) [SA, AA, SB, RGr, EL, RAL, RKO], funded by the UK Medical Research Council, Engineering and Physical Sciences Research Council, Economic and Social Research Council, Department of Health and Social Care (England), Chief Scientist Office of the Scottish Government Health and Social Care Directorates, Health and Social Care Research and Development Division (Welsh Government), Public Health Agency (Northern Ireland), British Heart Foundation (BHF) and the Wellcome Trust. This work was supported by the Administrative Data Research (ADR) Wales programme of work. ADR Wales, part of the ADR UK investment, unites research expertise from Swansea University Medical School and WISERD (Wales Institute of Social and Economic Research and Data) at Cardiff University with analysts from Welsh Government. ADR UK is funded by the Economic and Social Research Council (ESRC), part of UK Research and Innovation. This research was supported by ESRC funding, including Administrative Data Research Wales (ES/W012227/1) [AA, SB, RAL]. Additionally the authors acknowledge the support of BREATHE—The Health Data Research Hub for Respiratory Health (MC_PC_19004) [AS], which is funded through the UK Research and Innovation Industrial Strategy Challenge Fund and delivered through Health Data Research UK. This work was also supported by the Con-COV team funded by the Medical Research Council (grant number: MR/V028367/1) [AA, RAL]. 2024-07-15T11:47:13.1252678 2024-03-17T17:35:23.8691718 Faculty of Medicine, Health and Life Sciences Swansea University Medical School - Health Data Science Sarah Aldridge 1 Utkarsh Agrawal 2 Siobhán Murphy 3 Tristan Millington 4 Ashley Akbari 0000-0003-0814-0801 5 Fatima Almaghrabi 6 Sneha N. Anand 7 Stuart Bedston 8 Rosalind Goudie 9 Rowena Griffiths 10 Mark Joy 11 Emily Lowthian 0000-0001-9362-0046 12 Simon de Lusignan 0000-0002-8553-2641 13 Lynsey Patterson 14 Chris Robertson 0000-0001-6848-5241 15 Igor Rudan 16 Declan T. Bradley 0000-0003-1468-1823 17 Ronan Lyons 0000-0001-5225-000X 18 Aziz Sheikh 19 Rhiannon Owen 0000-0001-5977-376X 20 65851__29798__113a842c601d4a239cefc5f9b342d575.pdf 65851.VOR.pdf 2024-03-22T11:20:38.7793310 Output 2127715 application/pdf Version of Record true This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. true eng http://creativecommons.org/licenses/by/4.0/ 237 Sarah Aldridge true https://doi.org/10.1038/s41467-024-46451-0 false |
title |
Uptake of COVID-19 vaccinations amongst 3,433,483 children and young people: meta-analysis of UK prospective cohorts |
spellingShingle |
Uptake of COVID-19 vaccinations amongst 3,433,483 children and young people: meta-analysis of UK prospective cohorts Sarah Aldridge Ashley Akbari Stuart Bedston Rowena Griffiths Emily Lowthian Ronan Lyons Rhiannon Owen |
title_short |
Uptake of COVID-19 vaccinations amongst 3,433,483 children and young people: meta-analysis of UK prospective cohorts |
title_full |
Uptake of COVID-19 vaccinations amongst 3,433,483 children and young people: meta-analysis of UK prospective cohorts |
title_fullStr |
Uptake of COVID-19 vaccinations amongst 3,433,483 children and young people: meta-analysis of UK prospective cohorts |
title_full_unstemmed |
Uptake of COVID-19 vaccinations amongst 3,433,483 children and young people: meta-analysis of UK prospective cohorts |
title_sort |
Uptake of COVID-19 vaccinations amongst 3,433,483 children and young people: meta-analysis of UK prospective cohorts |
author_id_str_mv |
a42ee8ba1ff8174d5bb62d2d95364b90 aa1b025ec0243f708bb5eb0a93d6fb52 c79d07eaba5c9515c0df82b372b76a41 381464f639f98bd388c29326ca7f862c db5bc529b8a9dfca2b4a268d14e03479 83efcf2a9dfcf8b55586999d3d152ac6 0d30aa00eef6528f763a1e1589f703ec |
author_id_fullname_str_mv |
a42ee8ba1ff8174d5bb62d2d95364b90_***_Sarah Aldridge aa1b025ec0243f708bb5eb0a93d6fb52_***_Ashley Akbari c79d07eaba5c9515c0df82b372b76a41_***_Stuart Bedston 381464f639f98bd388c29326ca7f862c_***_Rowena Griffiths db5bc529b8a9dfca2b4a268d14e03479_***_Emily Lowthian 83efcf2a9dfcf8b55586999d3d152ac6_***_Ronan Lyons 0d30aa00eef6528f763a1e1589f703ec_***_Rhiannon Owen |
author |
Sarah Aldridge Ashley Akbari Stuart Bedston Rowena Griffiths Emily Lowthian Ronan Lyons Rhiannon Owen |
author2 |
Sarah Aldridge Utkarsh Agrawal Siobhán Murphy Tristan Millington Ashley Akbari Fatima Almaghrabi Sneha N. Anand Stuart Bedston Rosalind Goudie Rowena Griffiths Mark Joy Emily Lowthian Simon de Lusignan Lynsey Patterson Chris Robertson Igor Rudan Declan T. Bradley Ronan Lyons Aziz Sheikh Rhiannon Owen |
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Nature Communications |
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Swansea University |
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2041-1723 |
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10.1038/s41467-024-46451-0 |
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Springer Science and Business Media LLC |
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Faculty of Medicine, Health and Life Sciences |
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SARS-CoV-2 infection in children and young people (CYP) can lead to life-threatening COVID-19, transmission within households and schools, and the development of long COVID. Using linked health and administrative data, we investigated vaccine uptake among 3,433,483 CYP aged 5–17 years across all UK nations between 4th August 2021 and 31st May 2022. We constructed national cohorts and undertook multi-state modelling and meta-analysis to identify associations between demographic variables and vaccine uptake. We found that uptake of the first COVID-19 vaccine among CYP was low across all four nations compared to other age groups and diminished with subsequent doses. Age and vaccination status of adults living in the same household were identified as important risk factors associated with vaccine uptake in CYP. For example, 5–11 year-olds were less likely to receive their first vaccine compared to 16–17 year-olds (adjusted Hazard Ratio [aHR]: 0.10 (95%CI: 0.06–0.19)), and CYP in unvaccinated households were less likely to receive their first vaccine compared to CYP in partially vaccinated households (aHR: 0.19, 95%CI 0.13–0.29). |
published_date |
2024-03-15T11:47:12Z |
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