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Impact of nocturnal hypoxia on glycaemic control, appetite, gut microbiota and inflammation in adults with type 2 diabetes mellitus: A single‐blind cross‐over trial

Anthony I. Shepherd Orcid Logo, Thomas J. James Orcid Logo, Alex A. M. Gould, Harry Mayes, Rebecca Neal Orcid Logo, Janis Shute, Michael J. Tipton Orcid Logo, Heather Massey Orcid Logo, Zoe L. Saynor, Maria Perissiou Orcid Logo, Hugh Montgomery, Connie Sturgess, Janine Makaronidis, Andrew J. Murray, Michael P. W. Grocott, Michael Cummings, Steven Young‐Min Orcid Logo, Janet Rennell‐Smyth, Melitta McNarry Orcid Logo, Kelly Mackintosh Orcid Logo, Hannah Dent, Samuel C. Robson, Jo Corbett

The Journal of Physiology

Swansea University Authors: Melitta McNarry Orcid Logo, Kelly Mackintosh Orcid Logo

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DOI (Published version): 10.1113/jp285322

Abstract

High altitude residents have a lower incidence of type 2 diabetes mellitus (T2DM).Therefore, we examined the effect of repeated overnight normobaric hypoxic exposure on glycaemiccontrol, appetite, gut microbiota and inflammation in adults with T2DM. Thirteen adults withT2DM [glycated haemoglobin (Hb...

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Published in: The Journal of Physiology
ISSN: 0022-3751 1469-7793
Published: Wiley 2024
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URI: https://cronfa.swan.ac.uk/Record/cronfa67841
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Thirteen adults withT2DM [glycated haemoglobin (HbA1 c ): 61.1 ± 14.1 mmol mol−1 ; aged 64.2 ± 9.4 years; fourfemale] completed a single-blind, randomised, sham-controlled, cross-over study for 10 nights,sleeping when exposed to hypoxia (fractional inspired O2 [FIO 2 ] = 0.155; ∼2500 m simulatedaltitude) or normoxic conditions (FIO 2 = 0.209) in a randomised order. Outcome measures included:fasted plasma [glucose]; [hypoxia inducible factor-1α]; [interleukin-6]; [tumour necrosis factor-α];[interleukin-10]; [heat shock protein 70]; [butyric acid]; peak plasma [glucose] and insulin sensitivityfollowing a 2 h oral glucose tolerance test; body composition; appetite indices ([leptin], [acyl ghrelin],[peptide YY], [glucagon-like peptide-1]); and gut microbiota diversity and abundance [16S rRNAamplicon sequencing]. During intervention periods, accelerometers measured physical activity,sleep duration and efficiency, whereas continuous glucose monitors were used to assess estimatedHbA1c and glucose management indicator and time in target range. Overnight hypoxia was notassociated with changes in any outcome measure (P &gt; 0.05 with small effect sizes) except fastinginsulin sensitivity and gut microbiota alpha diversity, which exhibited trends (P = 0.10; P = 0.08respectively) for a medium beneficial effect (d = 0.49; d = 0.59 respectively). Ten nights of over-night moderate hypoxic exposure did not significantly affect glycaemic control, gut microbiome,appetite, or inflammation in adults with T2DM. 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spelling v2 67841 2024-09-26 Impact of nocturnal hypoxia on glycaemic control, appetite, gut microbiota and inflammation in adults with type 2 diabetes mellitus: A single‐blind cross‐over trial 062f5697ff59f004bc8c713955988398 0000-0003-0813-7477 Melitta McNarry Melitta McNarry true false bdb20e3f31bcccf95c7bc116070c4214 0000-0003-0355-6357 Kelly Mackintosh Kelly Mackintosh true false 2024-09-26 EAAS High altitude residents have a lower incidence of type 2 diabetes mellitus (T2DM).Therefore, we examined the effect of repeated overnight normobaric hypoxic exposure on glycaemiccontrol, appetite, gut microbiota and inflammation in adults with T2DM. Thirteen adults withT2DM [glycated haemoglobin (HbA1 c ): 61.1 ± 14.1 mmol mol−1 ; aged 64.2 ± 9.4 years; fourfemale] completed a single-blind, randomised, sham-controlled, cross-over study for 10 nights,sleeping when exposed to hypoxia (fractional inspired O2 [FIO 2 ] = 0.155; ∼2500 m simulatedaltitude) or normoxic conditions (FIO 2 = 0.209) in a randomised order. Outcome measures included:fasted plasma [glucose]; [hypoxia inducible factor-1α]; [interleukin-6]; [tumour necrosis factor-α];[interleukin-10]; [heat shock protein 70]; [butyric acid]; peak plasma [glucose] and insulin sensitivityfollowing a 2 h oral glucose tolerance test; body composition; appetite indices ([leptin], [acyl ghrelin],[peptide YY], [glucagon-like peptide-1]); and gut microbiota diversity and abundance [16S rRNAamplicon sequencing]. During intervention periods, accelerometers measured physical activity,sleep duration and efficiency, whereas continuous glucose monitors were used to assess estimatedHbA1c and glucose management indicator and time in target range. Overnight hypoxia was notassociated with changes in any outcome measure (P > 0.05 with small effect sizes) except fastinginsulin sensitivity and gut microbiota alpha diversity, which exhibited trends (P = 0.10; P = 0.08respectively) for a medium beneficial effect (d = 0.49; d = 0.59 respectively). Ten nights of over-night moderate hypoxic exposure did not significantly affect glycaemic control, gut microbiome,appetite, or inflammation in adults with T2DM. However, the intervention was well tolerated anda medium effect-size for improved insulin sensitivity and reduced alpha diversity warrants furtherinvestigation. Journal Article The Journal of Physiology 0 Wiley 0022-3751 1469-7793 accelerometery; exercise mimetic; hypoxia; type 2 diabetes; weight loss 20 5 2024 2024-05-20 10.1113/jp285322 COLLEGE NANME Engineering and Applied Sciences School COLLEGE CODE EAAS Swansea University Another institution paid the OA fee This work was funded by the Prince Faisal bin Fahad Awardfor Sports Research, administered by the Leaders DevelopmentInstitute under the Ministry of Sport in Saudi Arabia. Thecontent is solely the responsibility of the authors and doesnot necessarily represent the official views of the LeadersDevelopment Institute or the Ministry of Sport in Saudi Arabia. 2024-10-18T12:06:33.6020997 2024-09-26T10:51:22.9035197 Faculty of Science and Engineering School of Engineering and Applied Sciences - Sport and Exercise Sciences Anthony I. Shepherd 0000-0001-6392-7944 1 Thomas J. James 0000-0003-1470-9400 2 Alex A. M. Gould 3 Harry Mayes 4 Rebecca Neal 0000-0003-2065-0011 5 Janis Shute 6 Michael J. Tipton 0000-0002-7928-8451 7 Heather Massey 0000-0002-7542-513x 8 Zoe L. Saynor 9 Maria Perissiou 0000-0002-3974-2250 10 Hugh Montgomery 11 Connie Sturgess 12 Janine Makaronidis 13 Andrew J. Murray 14 Michael P. W. Grocott 15 Michael Cummings 16 Steven Young‐Min 0000-0001-8270-6207 17 Janet Rennell‐Smyth 18 Melitta McNarry 0000-0003-0813-7477 19 Kelly Mackintosh 0000-0003-0355-6357 20 Hannah Dent 21 Samuel C. Robson 22 Jo Corbett 23 67841__31459__1366788855d8478c886b49171df0c5d9.pdf 67841.pdf 2024-09-26T10:54:55.3507640 Output 2335897 application/pdf Version of Record true © 2024 The Authors. This is an open access article under the terms of the Creative Commons Attribution License. true eng http://creativecommons.org/licenses/by/4.0/
title Impact of nocturnal hypoxia on glycaemic control, appetite, gut microbiota and inflammation in adults with type 2 diabetes mellitus: A single‐blind cross‐over trial
spellingShingle Impact of nocturnal hypoxia on glycaemic control, appetite, gut microbiota and inflammation in adults with type 2 diabetes mellitus: A single‐blind cross‐over trial
Melitta McNarry
Kelly Mackintosh
title_short Impact of nocturnal hypoxia on glycaemic control, appetite, gut microbiota and inflammation in adults with type 2 diabetes mellitus: A single‐blind cross‐over trial
title_full Impact of nocturnal hypoxia on glycaemic control, appetite, gut microbiota and inflammation in adults with type 2 diabetes mellitus: A single‐blind cross‐over trial
title_fullStr Impact of nocturnal hypoxia on glycaemic control, appetite, gut microbiota and inflammation in adults with type 2 diabetes mellitus: A single‐blind cross‐over trial
title_full_unstemmed Impact of nocturnal hypoxia on glycaemic control, appetite, gut microbiota and inflammation in adults with type 2 diabetes mellitus: A single‐blind cross‐over trial
title_sort Impact of nocturnal hypoxia on glycaemic control, appetite, gut microbiota and inflammation in adults with type 2 diabetes mellitus: A single‐blind cross‐over trial
author_id_str_mv 062f5697ff59f004bc8c713955988398
bdb20e3f31bcccf95c7bc116070c4214
author_id_fullname_str_mv 062f5697ff59f004bc8c713955988398_***_Melitta McNarry
bdb20e3f31bcccf95c7bc116070c4214_***_Kelly Mackintosh
author Melitta McNarry
Kelly Mackintosh
author2 Anthony I. Shepherd
Thomas J. James
Alex A. M. Gould
Harry Mayes
Rebecca Neal
Janis Shute
Michael J. Tipton
Heather Massey
Zoe L. Saynor
Maria Perissiou
Hugh Montgomery
Connie Sturgess
Janine Makaronidis
Andrew J. Murray
Michael P. W. Grocott
Michael Cummings
Steven Young‐Min
Janet Rennell‐Smyth
Melitta McNarry
Kelly Mackintosh
Hannah Dent
Samuel C. Robson
Jo Corbett
format Journal article
container_title The Journal of Physiology
container_volume 0
publishDate 2024
institution Swansea University
issn 0022-3751
1469-7793
doi_str_mv 10.1113/jp285322
publisher Wiley
college_str Faculty of Science and Engineering
hierarchytype
hierarchy_top_id facultyofscienceandengineering
hierarchy_top_title Faculty of Science and Engineering
hierarchy_parent_id facultyofscienceandengineering
hierarchy_parent_title Faculty of Science and Engineering
department_str School of Engineering and Applied Sciences - Sport and Exercise Sciences{{{_:::_}}}Faculty of Science and Engineering{{{_:::_}}}School of Engineering and Applied Sciences - Sport and Exercise Sciences
document_store_str 1
active_str 0
description High altitude residents have a lower incidence of type 2 diabetes mellitus (T2DM).Therefore, we examined the effect of repeated overnight normobaric hypoxic exposure on glycaemiccontrol, appetite, gut microbiota and inflammation in adults with T2DM. Thirteen adults withT2DM [glycated haemoglobin (HbA1 c ): 61.1 ± 14.1 mmol mol−1 ; aged 64.2 ± 9.4 years; fourfemale] completed a single-blind, randomised, sham-controlled, cross-over study for 10 nights,sleeping when exposed to hypoxia (fractional inspired O2 [FIO 2 ] = 0.155; ∼2500 m simulatedaltitude) or normoxic conditions (FIO 2 = 0.209) in a randomised order. Outcome measures included:fasted plasma [glucose]; [hypoxia inducible factor-1α]; [interleukin-6]; [tumour necrosis factor-α];[interleukin-10]; [heat shock protein 70]; [butyric acid]; peak plasma [glucose] and insulin sensitivityfollowing a 2 h oral glucose tolerance test; body composition; appetite indices ([leptin], [acyl ghrelin],[peptide YY], [glucagon-like peptide-1]); and gut microbiota diversity and abundance [16S rRNAamplicon sequencing]. During intervention periods, accelerometers measured physical activity,sleep duration and efficiency, whereas continuous glucose monitors were used to assess estimatedHbA1c and glucose management indicator and time in target range. Overnight hypoxia was notassociated with changes in any outcome measure (P > 0.05 with small effect sizes) except fastinginsulin sensitivity and gut microbiota alpha diversity, which exhibited trends (P = 0.10; P = 0.08respectively) for a medium beneficial effect (d = 0.49; d = 0.59 respectively). Ten nights of over-night moderate hypoxic exposure did not significantly affect glycaemic control, gut microbiome,appetite, or inflammation in adults with T2DM. However, the intervention was well tolerated anda medium effect-size for improved insulin sensitivity and reduced alpha diversity warrants furtherinvestigation.
published_date 2024-05-20T12:06:32Z
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