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Growth Factor Concentrations in Human Milk Are Associated With Infant Weight and BMI From Birth to 5 Years

Laura Galante Orcid Logo, Shikha Pundir, Hanna Lagström, Samuli Rautava, Clare Marie Reynolds, Amber Marie Milan, David Cameron-Smith, Mark Hedley Vickers

Frontiers in Nutrition, Volume: 7

Swansea University Author: Laura Galante Orcid Logo

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DOI (Published version): 10.3389/fnut.2020.00110

Abstract

Background: Human milk bioactives may play a role in infant health and development. Although the variability in their concentrations in milk is well-established, the impact of differential milk profiles on infant growth outcomes remains unclear. Thus, the aim of the present study was to investigate...

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Published in: Frontiers in Nutrition
ISSN: 2296-861X
Published: Frontiers Media SA 2020
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URI: https://cronfa.swan.ac.uk/Record/cronfa68015
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spelling 2024-12-20T12:58:16.0729382 v2 68015 2024-10-18 Growth Factor Concentrations in Human Milk Are Associated With Infant Weight and BMI From Birth to 5 Years d1c6c22f6a863ef2050ed9768566884b 0000-0002-6190-7955 Laura Galante Laura Galante true false 2024-10-18 MEDS Background: Human milk bioactives may play a role in infant health and development. Although the variability in their concentrations in milk is well-established, the impact of differential milk profiles on infant growth outcomes remains unclear. Thus, the aim of the present study was to investigate whether different concentrations of metabolic hormones are associated with different weight and BMI in infants beyond the first year of life.Methods: Milk samples at 2.6 (±0.4) months after birth and anthropometric measures at 13 months, 2, 3, and 5 years were collected as part of the Finnish STEPS cohort study from 501 mothers and the respective 507 infants. Leptin, adiponectin, insulin-like growth factor (IGF)-1 and cyclic glycine-proline (cGP) in milk were analyzed. Multiple regression models and a repeated measures mixed model were used to examine associations between milk hormone concentrations and weight and BMI z-scores across time, at each time-point, and weight gain from birth to each follow-up visit. All models were corrected for birth weight, infant sex, duration of exclusive and total breastfeeding, time of introduction of solid foods and maternal pre-pregnancy BMI.Results: Higher milk IGF-1 was associated with higher weight at 13 months (p = 0.004) but lower weight at 3 (p = 0.011) and 5 years of age (p = 0.049). Higher cGP was associated with lower weight across the 5 years (p = 0.019) but with higher BMI at 5 years (p = 0.021). Leptin and adiponectin did not display associations with infant growth at this time. Sex interactions were also absent.Conclusions: Our results suggest that the interplay between human milk-borne IGF-1 and cGP is similar to that reported in other mammals and may have an important role in defining infant growth trajectories beyond the first year of life. Further research should explore the determinants and origins of these milk-borne compounds and evaluate their effect on infant growth and metabolism. Journal Article Frontiers in Nutrition 7 Frontiers Media SA 2296-861X BMI, cGP, human breastmilk bioactives, IGF-1, growth factors, adiponectin, leptin, infant growth 29 7 2020 2020-07-29 10.3389/fnut.2020.00110 COLLEGE NANME Medical School COLLEGE CODE MEDS Swansea University Another institution paid the OA fee This analysis was funded by the Liggins Institute FRDF (Faculty Research Development Fund, Grant No. 3716954) and University of Auckland Foundation (Grant No. 3708092). The clinical study and collection of samples was funded by the Academy of Finland (Grants Nos. 121569 and 123571). 2024-12-20T12:58:16.0729382 2024-10-18T08:56:50.5711710 Faculty of Medicine, Health and Life Sciences School of Health and Social Care - Public Health Laura Galante 0000-0002-6190-7955 1 Shikha Pundir 2 Hanna Lagström 3 Samuli Rautava 4 Clare Marie Reynolds 5 Amber Marie Milan 6 David Cameron-Smith 7 Mark Hedley Vickers 8
title Growth Factor Concentrations in Human Milk Are Associated With Infant Weight and BMI From Birth to 5 Years
spellingShingle Growth Factor Concentrations in Human Milk Are Associated With Infant Weight and BMI From Birth to 5 Years
Laura Galante
title_short Growth Factor Concentrations in Human Milk Are Associated With Infant Weight and BMI From Birth to 5 Years
title_full Growth Factor Concentrations in Human Milk Are Associated With Infant Weight and BMI From Birth to 5 Years
title_fullStr Growth Factor Concentrations in Human Milk Are Associated With Infant Weight and BMI From Birth to 5 Years
title_full_unstemmed Growth Factor Concentrations in Human Milk Are Associated With Infant Weight and BMI From Birth to 5 Years
title_sort Growth Factor Concentrations in Human Milk Are Associated With Infant Weight and BMI From Birth to 5 Years
author_id_str_mv d1c6c22f6a863ef2050ed9768566884b
author_id_fullname_str_mv d1c6c22f6a863ef2050ed9768566884b_***_Laura Galante
author Laura Galante
author2 Laura Galante
Shikha Pundir
Hanna Lagström
Samuli Rautava
Clare Marie Reynolds
Amber Marie Milan
David Cameron-Smith
Mark Hedley Vickers
format Journal article
container_title Frontiers in Nutrition
container_volume 7
publishDate 2020
institution Swansea University
issn 2296-861X
doi_str_mv 10.3389/fnut.2020.00110
publisher Frontiers Media SA
college_str Faculty of Medicine, Health and Life Sciences
hierarchytype
hierarchy_top_id facultyofmedicinehealthandlifesciences
hierarchy_top_title Faculty of Medicine, Health and Life Sciences
hierarchy_parent_id facultyofmedicinehealthandlifesciences
hierarchy_parent_title Faculty of Medicine, Health and Life Sciences
department_str School of Health and Social Care - Public Health{{{_:::_}}}Faculty of Medicine, Health and Life Sciences{{{_:::_}}}School of Health and Social Care - Public Health
document_store_str 0
active_str 0
description Background: Human milk bioactives may play a role in infant health and development. Although the variability in their concentrations in milk is well-established, the impact of differential milk profiles on infant growth outcomes remains unclear. Thus, the aim of the present study was to investigate whether different concentrations of metabolic hormones are associated with different weight and BMI in infants beyond the first year of life.Methods: Milk samples at 2.6 (±0.4) months after birth and anthropometric measures at 13 months, 2, 3, and 5 years were collected as part of the Finnish STEPS cohort study from 501 mothers and the respective 507 infants. Leptin, adiponectin, insulin-like growth factor (IGF)-1 and cyclic glycine-proline (cGP) in milk were analyzed. Multiple regression models and a repeated measures mixed model were used to examine associations between milk hormone concentrations and weight and BMI z-scores across time, at each time-point, and weight gain from birth to each follow-up visit. All models were corrected for birth weight, infant sex, duration of exclusive and total breastfeeding, time of introduction of solid foods and maternal pre-pregnancy BMI.Results: Higher milk IGF-1 was associated with higher weight at 13 months (p = 0.004) but lower weight at 3 (p = 0.011) and 5 years of age (p = 0.049). Higher cGP was associated with lower weight across the 5 years (p = 0.019) but with higher BMI at 5 years (p = 0.021). Leptin and adiponectin did not display associations with infant growth at this time. Sex interactions were also absent.Conclusions: Our results suggest that the interplay between human milk-borne IGF-1 and cGP is similar to that reported in other mammals and may have an important role in defining infant growth trajectories beyond the first year of life. Further research should explore the determinants and origins of these milk-borne compounds and evaluate their effect on infant growth and metabolism.
published_date 2020-07-29T02:56:00Z
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score 11.048302

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