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Recent progress in electrochemical assessment of DNA based on nanostructured sensors

Lue Wang, Waye Zhang Orcid Logo

Biomedical Microdevices, Volume: 27

Swansea University Author: Waye Zhang Orcid Logo

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DOI (Published version): 10.1007/s10544-025-00763-0

Abstract

Screening the amount of DNA closely related to early diagnosis of diseases or decoding information in target DNA sequences for biological medicine, infectious identification, or forensic analysis are highly essential in our daily life. This review provides clear understanding of nanostructured senso...

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Published in: Biomedical Microdevices
ISSN: 1387-2176 1572-8781
Published: Springer Science and Business Media LLC 2025
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URI: https://cronfa.swan.ac.uk/Record/cronfa69901
first_indexed 2025-07-07T08:06:24Z
last_indexed 2025-07-26T10:29:18Z
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spelling 2025-07-25T16:02:07.0642341 v2 69901 2025-07-07 Recent progress in electrochemical assessment of DNA based on nanostructured sensors 3ddabbb54b2cfa2ea10f590ea7da6520 0000-0003-3129-2918 Waye Zhang Waye Zhang true false 2025-07-07 EAAS Screening the amount of DNA closely related to early diagnosis of diseases or decoding information in target DNA sequences for biological medicine, infectious identification, or forensic analysis are highly essential in our daily life. This review provides clear understanding of nanostructured sensors (i.e., functionalized electrode-based sensors and nanopores) working for electrochemical assessment of DNA, along with their recent advances and unaddressed issues. Crucial constituents for sensor functionalization, electrochemical techniques, and electrodes, used in functionalized electrode-based sensors are briefly introduced, followed by analysis of using this type of sensors for DNA determination and the comparison of performances such as dynamic ranges and detection limits with other similar works. Subsequently, nanopore sensors including porin-based and solid-state nanopores applied for DNA sequencing are the other interests of discussion in the review. Beyond the achievement of high-resolution DNA sequencing based on porins coupled with enzymatic components, commonly used methods to solid-state nanopore creation, practical use of solid-state nanopores in DNA analysis, and computational modeling for nucleobase pore-threading simulation are depicted in more detail. Finally, conclusions in relation to recent advances and future developments are described. This work offers a powerful guideline for electrochemical assessment of DNA using either functionalized electrode-based sensors or nanopores, enabling scientific groups to have an entire picture upon electrochemical nanodevices used for DNA characterization. Journal Article Biomedical Microdevices 27 Springer Science and Business Media LLC 1387-2176 1572-8781 Electrochemical; DNA; Nanosensors 12 7 2025 2025-07-12 10.1007/s10544-025-00763-0 COLLEGE NANME Engineering and Applied Sciences School COLLEGE CODE EAAS Swansea University SU Library paid the OA fee (TA Institutional Deal) Shuimu Tsinghua Scholar Program (2023SM195); EPSRC International Doctoral Scholars—IDS grant NCZ1080-EP/W524694/1-2323187 2025-07-25T16:02:07.0642341 2025-07-07T08:59:50.6178277 Faculty of Science and Engineering School of Engineering and Applied Sciences - Chemical Engineering Lue Wang 1 Waye Zhang 0000-0003-3129-2918 2 69901__34846__03bfeb303fc64c229da6f4004de50c9b.pdf 69901.VoR.pdf 2025-07-25T15:55:32.7807485 Output 3908698 application/pdf Version of Record true © The Author(s) 2025. This article is licensed under a Creative Commons Attribution 4.0 International License. true eng http://creativecommons.org/licenses/by/4.0/
title Recent progress in electrochemical assessment of DNA based on nanostructured sensors
spellingShingle Recent progress in electrochemical assessment of DNA based on nanostructured sensors
Waye Zhang
title_short Recent progress in electrochemical assessment of DNA based on nanostructured sensors
title_full Recent progress in electrochemical assessment of DNA based on nanostructured sensors
title_fullStr Recent progress in electrochemical assessment of DNA based on nanostructured sensors
title_full_unstemmed Recent progress in electrochemical assessment of DNA based on nanostructured sensors
title_sort Recent progress in electrochemical assessment of DNA based on nanostructured sensors
author_id_str_mv 3ddabbb54b2cfa2ea10f590ea7da6520
author_id_fullname_str_mv 3ddabbb54b2cfa2ea10f590ea7da6520_***_Waye Zhang
author Waye Zhang
author2 Lue Wang
Waye Zhang
format Journal article
container_title Biomedical Microdevices
container_volume 27
publishDate 2025
institution Swansea University
issn 1387-2176
1572-8781
doi_str_mv 10.1007/s10544-025-00763-0
publisher Springer Science and Business Media LLC
college_str Faculty of Science and Engineering
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hierarchy_top_id facultyofscienceandengineering
hierarchy_top_title Faculty of Science and Engineering
hierarchy_parent_id facultyofscienceandengineering
hierarchy_parent_title Faculty of Science and Engineering
department_str School of Engineering and Applied Sciences - Chemical Engineering{{{_:::_}}}Faculty of Science and Engineering{{{_:::_}}}School of Engineering and Applied Sciences - Chemical Engineering
document_store_str 1
active_str 0
description Screening the amount of DNA closely related to early diagnosis of diseases or decoding information in target DNA sequences for biological medicine, infectious identification, or forensic analysis are highly essential in our daily life. This review provides clear understanding of nanostructured sensors (i.e., functionalized electrode-based sensors and nanopores) working for electrochemical assessment of DNA, along with their recent advances and unaddressed issues. Crucial constituents for sensor functionalization, electrochemical techniques, and electrodes, used in functionalized electrode-based sensors are briefly introduced, followed by analysis of using this type of sensors for DNA determination and the comparison of performances such as dynamic ranges and detection limits with other similar works. Subsequently, nanopore sensors including porin-based and solid-state nanopores applied for DNA sequencing are the other interests of discussion in the review. Beyond the achievement of high-resolution DNA sequencing based on porins coupled with enzymatic components, commonly used methods to solid-state nanopore creation, practical use of solid-state nanopores in DNA analysis, and computational modeling for nucleobase pore-threading simulation are depicted in more detail. Finally, conclusions in relation to recent advances and future developments are described. This work offers a powerful guideline for electrochemical assessment of DNA using either functionalized electrode-based sensors or nanopores, enabling scientific groups to have an entire picture upon electrochemical nanodevices used for DNA characterization.
published_date 2025-07-12T18:01:01Z
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