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Heteromultivalent Nanogels as Highly Potent Inhibitors of <i>Pseudomonas Aeruginosa</i>
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Chuanxiong Nie ,
Boyu Zheng,
Vinod Khatri ,
Denis Puccio,
Yanping Long,
Mathias Dimde,
Rainer Haag ,
Sumati Bhatia
Angewandte Chemie International Edition, Volume: 64, Issue: 52, Start page: e13121
Swansea University Author:
Sumati Bhatia
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DOI (Published version): 10.1002/anie.202513121
Abstract
The increasing prevalence of microbial resistance requires new antibacterial concepts for selective targeting and killing of pathogenic bacteria. Here, we report the synthesis of a heteromultivalent nanogel system against Pseudomonas aeruginosa (P. aeruginosa). These nanogels are based on biocompati...
| Published in: | Angewandte Chemie International Edition |
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| ISSN: | 1433-7851 1521-3773 |
| Published: |
Wiley
2025
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| Online Access: |
Check full text
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| URI: | https://cronfa.swan.ac.uk/Record/cronfa71238 |
| Abstract: |
The increasing prevalence of microbial resistance requires new antibacterial concepts for selective targeting and killing of pathogenic bacteria. Here, we report the synthesis of a heteromultivalent nanogel system against Pseudomonas aeruginosa (P. aeruginosa). These nanogels are based on biocompatible polyglycerols and functionalized with sugar ligands fucose (Fuc) or galactose (Gal) for P. aeruginosa targeting. With a further modification of these nanogels with BMAP-18 short chain peptides (GRFKRFRKKFKKLFKKLS), we have achieved > 99.99% inactivation of planktonic and > 99.9% inactivation of biofilm-coated P. aeruginosa within 12 h of treatment. Additionally, the system demonstrates broad-spectrum antimicrobial potential, effectively inhibiting Escherichia coli (E. coli) and Methicillin-resistant Staphylococcus aureus (MRSA). This modular design offers a promising strategy for the development of next-generation antimicrobial therapies targeting biofilm-associated infections and MDR bacteria. |
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| Item Description: |
Communication |
| Keywords: |
Bacteria inactivation; Biofilm dispersion; Heteromultivalent nanogels; Pseudomonas aeruginosa |
| College: |
Faculty of Science and Engineering |
| Funders: |
Deutsche Forschungsgemeinschaft. Grant Numbers: SFB 1449, 458564133;
Chinese Scholarship Council;
ERC. Grant Number: 101055416;
Royal Society of Chemistry. Grant Number: RG∖R1∖241050;
HORIZON EUROPE European Research Council. Grant Number: ERC grant SupraVir – Project Number: 101055416;
Open access funding enabled and organized by Projekt DEAL. |
| Issue: |
52 |
| Start Page: |
e13121 |