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Heteromultivalent Nanogels as Highly Potent Inhibitors of <i>Pseudomonas Aeruginosa</i>

Yuhang Jiang Orcid Logo, Chuanxiong Nie Orcid Logo, Boyu Zheng, Vinod Khatri Orcid Logo, Denis Puccio, Yanping Long, Mathias Dimde, Rainer Haag Orcid Logo, Sumati Bhatia Orcid Logo

Angewandte Chemie International Edition, Volume: 64, Issue: 52, Start page: e13121

Swansea University Author: Sumati Bhatia Orcid Logo

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DOI (Published version): 10.1002/anie.202513121

Abstract

The increasing prevalence of microbial resistance requires new antibacterial concepts for selective targeting and killing of pathogenic bacteria. Here, we report the synthesis of a heteromultivalent nanogel system against Pseudomonas aeruginosa (P. aeruginosa). These nanogels are based on biocompati...

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Published in: Angewandte Chemie International Edition
ISSN: 1433-7851 1521-3773
Published: Wiley 2025
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URI: https://cronfa.swan.ac.uk/Record/cronfa71238
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spelling 2026-01-13T15:25:09.6097009 v2 71238 2026-01-13 Heteromultivalent Nanogels as Highly Potent Inhibitors of <i>Pseudomonas Aeruginosa</i> a6b1181ebdbe42bd03b24cbdb559d082 0000-0002-5123-4937 Sumati Bhatia Sumati Bhatia true false 2026-01-13 EAAS The increasing prevalence of microbial resistance requires new antibacterial concepts for selective targeting and killing of pathogenic bacteria. Here, we report the synthesis of a heteromultivalent nanogel system against Pseudomonas aeruginosa (P. aeruginosa). These nanogels are based on biocompatible polyglycerols and functionalized with sugar ligands fucose (Fuc) or galactose (Gal) for P. aeruginosa targeting. With a further modification of these nanogels with BMAP-18 short chain peptides (GRFKRFRKKFKKLFKKLS), we have achieved > 99.99% inactivation of planktonic and > 99.9% inactivation of biofilm-coated P. aeruginosa within 12 h of treatment. Additionally, the system demonstrates broad-spectrum antimicrobial potential, effectively inhibiting Escherichia coli (E. coli) and Methicillin-resistant Staphylococcus aureus (MRSA). This modular design offers a promising strategy for the development of next-generation antimicrobial therapies targeting biofilm-associated infections and MDR bacteria. Journal Article Angewandte Chemie International Edition 64 52 e13121 Wiley 1433-7851 1521-3773 Bacteria inactivation; Biofilm dispersion; Heteromultivalent nanogels; Pseudomonas aeruginosa 22 12 2025 2025-12-22 10.1002/anie.202513121 Communication COLLEGE NANME Engineering and Applied Sciences School COLLEGE CODE EAAS Swansea University Another institution paid the OA fee Deutsche Forschungsgemeinschaft. Grant Numbers: SFB 1449, 458564133; Chinese Scholarship Council; ERC. Grant Number: 101055416; Royal Society of Chemistry. Grant Number: RG∖R1∖241050; HORIZON EUROPE European Research Council. Grant Number: ERC grant SupraVir – Project Number: 101055416; Open access funding enabled and organized by Projekt DEAL. 2026-01-13T15:25:09.6097009 2026-01-13T15:15:46.6810673 Faculty of Science and Engineering School of Engineering and Applied Sciences - Chemistry Yuhang Jiang 0009-0003-6570-245x 1 Chuanxiong Nie 0000-0001-7963-1187 2 Boyu Zheng 3 Vinod Khatri 0000-0002-7777-1984 4 Denis Puccio 5 Yanping Long 6 Mathias Dimde 7 Rainer Haag 0000-0003-3840-162x 8 Sumati Bhatia 0000-0002-5123-4937 9 71238__35985__af766ca68c1e449fb5b4304e27551bc5.pdf 71238.VOR.pdf 2026-01-13T15:22:49.0069901 Output 3966298 application/pdf Version of Record true © 2025 The Author(s). This is an open access article under the terms of the Creative Commons Attribution License. true eng http://creativecommons.org/licenses/by/4.0/
title Heteromultivalent Nanogels as Highly Potent Inhibitors of <i>Pseudomonas Aeruginosa</i>
spellingShingle Heteromultivalent Nanogels as Highly Potent Inhibitors of <i>Pseudomonas Aeruginosa</i>
Sumati Bhatia
title_short Heteromultivalent Nanogels as Highly Potent Inhibitors of <i>Pseudomonas Aeruginosa</i>
title_full Heteromultivalent Nanogels as Highly Potent Inhibitors of <i>Pseudomonas Aeruginosa</i>
title_fullStr Heteromultivalent Nanogels as Highly Potent Inhibitors of <i>Pseudomonas Aeruginosa</i>
title_full_unstemmed Heteromultivalent Nanogels as Highly Potent Inhibitors of <i>Pseudomonas Aeruginosa</i>
title_sort Heteromultivalent Nanogels as Highly Potent Inhibitors of <i>Pseudomonas Aeruginosa</i>
author_id_str_mv a6b1181ebdbe42bd03b24cbdb559d082
author_id_fullname_str_mv a6b1181ebdbe42bd03b24cbdb559d082_***_Sumati Bhatia
author Sumati Bhatia
author2 Yuhang Jiang
Chuanxiong Nie
Boyu Zheng
Vinod Khatri
Denis Puccio
Yanping Long
Mathias Dimde
Rainer Haag
Sumati Bhatia
format Journal article
container_title Angewandte Chemie International Edition
container_volume 64
container_issue 52
container_start_page e13121
publishDate 2025
institution Swansea University
issn 1433-7851
1521-3773
doi_str_mv 10.1002/anie.202513121
publisher Wiley
college_str Faculty of Science and Engineering
hierarchytype
hierarchy_top_id facultyofscienceandengineering
hierarchy_top_title Faculty of Science and Engineering
hierarchy_parent_id facultyofscienceandengineering
hierarchy_parent_title Faculty of Science and Engineering
department_str School of Engineering and Applied Sciences - Chemistry{{{_:::_}}}Faculty of Science and Engineering{{{_:::_}}}School of Engineering and Applied Sciences - Chemistry
document_store_str 1
active_str 0
description The increasing prevalence of microbial resistance requires new antibacterial concepts for selective targeting and killing of pathogenic bacteria. Here, we report the synthesis of a heteromultivalent nanogel system against Pseudomonas aeruginosa (P. aeruginosa). These nanogels are based on biocompatible polyglycerols and functionalized with sugar ligands fucose (Fuc) or galactose (Gal) for P. aeruginosa targeting. With a further modification of these nanogels with BMAP-18 short chain peptides (GRFKRFRKKFKKLFKKLS), we have achieved > 99.99% inactivation of planktonic and > 99.9% inactivation of biofilm-coated P. aeruginosa within 12 h of treatment. Additionally, the system demonstrates broad-spectrum antimicrobial potential, effectively inhibiting Escherichia coli (E. coli) and Methicillin-resistant Staphylococcus aureus (MRSA). This modular design offers a promising strategy for the development of next-generation antimicrobial therapies targeting biofilm-associated infections and MDR bacteria.
published_date 2025-12-22T05:33:36Z
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