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Emerging trends and structure–activity insights of Schiff base–lanthanide complexes as antibacterial agents

Sikandar Paswan Orcid Logo, Nitesh Jaiswal Orcid Logo, URVASHI URVASHI, Amar Nath Orcid Logo, Manoj Kumar Orcid Logo, Divya Mishra Orcid Logo, Navneet Yadav

RSC Advances, Volume: 16, Issue: 4, Pages: 3478 - 3508

Swansea University Authors: URVASHI URVASHI, Navneet Yadav

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DOI (Published version): 10.1039/d5ra08181e

Abstract

The rapid escalation of microbial resistance has accelerated the search for next-generation antibacterial agents with novel mechanisms of action. Schiff bases and their lanthanide complexes have emerged as promising candidates due to their tunable structures, coordination versatility and enhanced bi...

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Published in: RSC Advances
ISSN: 2046-2069
Published: Royal Society of Chemistry 2026
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URI: https://cronfa.swan.ac.uk/Record/cronfa71254
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last_indexed 2026-01-16T05:33:34Z
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spelling 2026-01-15T12:37:52.7634046 v2 71254 2026-01-15 Emerging trends and structure–activity insights of Schiff base–lanthanide complexes as antibacterial agents e963353f0b45f08075e2f078b81e0bf1 URVASHI URVASHI URVASHI URVASHI true true cd4b038baa1cf16ab644f0dd375df020 Navneet Yadav Navneet Yadav true false 2026-01-15 The rapid escalation of microbial resistance has accelerated the search for next-generation antibacterial agents with novel mechanisms of action. Schiff bases and their lanthanide complexes have emerged as promising candidates due to their tunable structures, coordination versatility and enhanced bioactivity upon metal binding. While earlier reviews laid the foundational understanding of antibacterial activity of Schiff bases and their metal complexes, this review advances the field by offering a data-driven, mechanistically informed and structure–activity-focused perspective on the most recent antibacterial findings (2018–2025) of Schiff bases and their Ln(iii) complexes. In this review article, we critically compare the antibacterial performance of diverse ligand frameworks with lanthanide ions, under varied experimental conditions against both Gram-negative and Gram-positive bacterial strains highlighting trends in structure–activity correlations. We also identify clear trends: Schiff base ligands alone usually show modest or weak antibacterial activity, which is significantly enhanced upon complexation with lanthanide ions. Additionally, unresolved challenges, including toxicity, bioavailability and resistance modulation are discussed alongside proposed future research pathways. This perspective aims to guide the rational design of Schiff base–lanthanide complexes toward clinical translation as potent antibacterial agents. Journal Article RSC Advances 16 4 3478 3508 Royal Society of Chemistry 2046-2069 15 1 2026 2026-01-15 10.1039/d5ra08181e Review COLLEGE NANME COLLEGE CODE Swansea University Other 2026-01-15T12:37:52.7634046 2026-01-15T12:28:25.5380886 Faculty of Science and Engineering School of Engineering and Applied Sciences - Chemical Engineering Sikandar Paswan 0000-0002-5815-1819 1 Nitesh Jaiswal 0000-0002-8327-4765 2 URVASHI URVASHI 3 Amar Nath 0009-0003-7511-6753 4 Manoj Kumar 0000-0002-2485-2406 5 Divya Mishra 0000-0003-2127-6113 6 Navneet Yadav 7 71254__36002__0f1c9c11205a4407a6db4a62f961e25a.pdf 71254.VOR.pdf 2026-01-15T12:35:19.9607794 Output 4928400 application/pdf Version of Record true © 2026 The Author(s). This Open Access Article is licensed under a Creative Commons Attribution-Non Commercial 3.0 Unported Licence. true eng http://creativecommons.org/licenses/by-nc/3.0/
title Emerging trends and structure–activity insights of Schiff base–lanthanide complexes as antibacterial agents
spellingShingle Emerging trends and structure–activity insights of Schiff base–lanthanide complexes as antibacterial agents
URVASHI URVASHI
Navneet Yadav
title_short Emerging trends and structure–activity insights of Schiff base–lanthanide complexes as antibacterial agents
title_full Emerging trends and structure–activity insights of Schiff base–lanthanide complexes as antibacterial agents
title_fullStr Emerging trends and structure–activity insights of Schiff base–lanthanide complexes as antibacterial agents
title_full_unstemmed Emerging trends and structure–activity insights of Schiff base–lanthanide complexes as antibacterial agents
title_sort Emerging trends and structure–activity insights of Schiff base–lanthanide complexes as antibacterial agents
author_id_str_mv e963353f0b45f08075e2f078b81e0bf1
cd4b038baa1cf16ab644f0dd375df020
author_id_fullname_str_mv e963353f0b45f08075e2f078b81e0bf1_***_URVASHI URVASHI
cd4b038baa1cf16ab644f0dd375df020_***_Navneet Yadav
author URVASHI URVASHI
Navneet Yadav
author2 Sikandar Paswan
Nitesh Jaiswal
URVASHI URVASHI
Amar Nath
Manoj Kumar
Divya Mishra
Navneet Yadav
format Journal article
container_title RSC Advances
container_volume 16
container_issue 4
container_start_page 3478
publishDate 2026
institution Swansea University
issn 2046-2069
doi_str_mv 10.1039/d5ra08181e
publisher Royal Society of Chemistry
college_str Faculty of Science and Engineering
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hierarchy_top_title Faculty of Science and Engineering
hierarchy_parent_id facultyofscienceandengineering
hierarchy_parent_title Faculty of Science and Engineering
department_str School of Engineering and Applied Sciences - Chemical Engineering{{{_:::_}}}Faculty of Science and Engineering{{{_:::_}}}School of Engineering and Applied Sciences - Chemical Engineering
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description The rapid escalation of microbial resistance has accelerated the search for next-generation antibacterial agents with novel mechanisms of action. Schiff bases and their lanthanide complexes have emerged as promising candidates due to their tunable structures, coordination versatility and enhanced bioactivity upon metal binding. While earlier reviews laid the foundational understanding of antibacterial activity of Schiff bases and their metal complexes, this review advances the field by offering a data-driven, mechanistically informed and structure–activity-focused perspective on the most recent antibacterial findings (2018–2025) of Schiff bases and their Ln(iii) complexes. In this review article, we critically compare the antibacterial performance of diverse ligand frameworks with lanthanide ions, under varied experimental conditions against both Gram-negative and Gram-positive bacterial strains highlighting trends in structure–activity correlations. We also identify clear trends: Schiff base ligands alone usually show modest or weak antibacterial activity, which is significantly enhanced upon complexation with lanthanide ions. Additionally, unresolved challenges, including toxicity, bioavailability and resistance modulation are discussed alongside proposed future research pathways. This perspective aims to guide the rational design of Schiff base–lanthanide complexes toward clinical translation as potent antibacterial agents.
published_date 2026-01-15T05:35:03Z
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