Journal article 77 views 6 downloads
Therapeutic Potential of Microalgae-Derived Bioactive Metabolites Is Influenced by Different Large-Scale Culture Strategies
,
Claudio Fuentes-Grünewald,
Deya Gonzalez
Marine Drugs, Volume: 20, Issue: 10, Start page: 627
Swansea University Author:
Deya Gonzalez
-
PDF | Version of Record
© 2022 by the authors. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license.
Download (5.87MB)
DOI (Published version): 10.3390/md20100627
Abstract
Microalgae have been identified as one of the most promising sources of novel bioactive compounds for biomedical applications, the food industry, and cosmetics. In the last decade, several biotechnological developments have facilitated the identification of a growing number of compounds as well as t...
| Published in: | Marine Drugs |
|---|---|
| ISSN: | 1660-3397 |
| Published: |
MDPI AG
2022
|
| Online Access: |
Check full text
|
| URI: | https://cronfa.swan.ac.uk/Record/cronfa71344 |
| Abstract: |
Microalgae have been identified as one of the most promising sources of novel bioactive compounds for biomedical applications, the food industry, and cosmetics. In the last decade, several biotechnological developments have facilitated the identification of a growing number of compounds as well as the study of optimal microalgae culture conditions for the production of biomass enriched in specific molecules of interest. In this study, two common commercial marine microalgae (Nannochloropsis oculata and Porphyridium purpureum) were cultured in standard and nutrient-stressed conditions and the obtained biomass extracts were assessed for their potential to inhibit cancer cell proliferation and migration as well as their antioxidant activity. Results from viability in 2D and 3D cancer cell models showed an enhancement of the antitumour activity of P. purpureum in the 3D model compared to 2D, together with a greater capacity to reduce the migration capacity of cancer cells with the biomass from nutrient-stressed conditions, whereas the antioxidant activity of N. oculata decreased when exposed to nutrient-stressed conditions. To date, this is one of the few studies that proves that controlled changes in large-scale culturing conditions such as nutrient depletion have a relevant impact in the bioactivity of the biomass on cancer cells. |
|---|---|
| Keywords: |
microalgae; cancer cells; antitumour; biomass; therapeutic; biotechnology |
| College: |
Faculty of Medicine, Health and Life Sciences |
| Funders: |
This project was funded by: Interreg Atlantic Area European Regional development fund, project Enhance Microalgae EAPA_338/2016 (C.F.G). Swansea University Medical School departmental funds (J.G.P. and D.G.), and Ministry of Environment, Water and Agriculture (MEWA) of the Kingdom of Saudi Arabia, project number: 52000003916, Development of Algal Biotechnology in the Kingdom of Saudi Arabia (C.F.G.). |
| Issue: |
10 |
| Start Page: |
627 |