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Therapeutic Potential of Microalgae-Derived Bioactive Metabolites Is Influenced by Different Large-Scale Culture Strategies

Jezabel Garcia-Parra Orcid Logo, Claudio Fuentes-Grünewald, Deya Gonzalez Orcid Logo

Marine Drugs, Volume: 20, Issue: 10, Start page: 627

Swansea University Author: Deya Gonzalez Orcid Logo

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DOI (Published version): 10.3390/md20100627

Abstract

Microalgae have been identified as one of the most promising sources of novel bioactive compounds for biomedical applications, the food industry, and cosmetics. In the last decade, several biotechnological developments have facilitated the identification of a growing number of compounds as well as t...

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Published in: Marine Drugs
ISSN: 1660-3397
Published: MDPI AG 2022
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URI: https://cronfa.swan.ac.uk/Record/cronfa71344
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spelling 2026-02-09T12:42:15.0997020 v2 71344 2026-01-29 Therapeutic Potential of Microalgae-Derived Bioactive Metabolites Is Influenced by Different Large-Scale Culture Strategies bafdf635eb81280304eedf4b18e65d4e 0000-0002-1838-6752 Deya Gonzalez Deya Gonzalez true false 2026-01-29 MEDS Microalgae have been identified as one of the most promising sources of novel bioactive compounds for biomedical applications, the food industry, and cosmetics. In the last decade, several biotechnological developments have facilitated the identification of a growing number of compounds as well as the study of optimal microalgae culture conditions for the production of biomass enriched in specific molecules of interest. In this study, two common commercial marine microalgae (Nannochloropsis oculata and Porphyridium purpureum) were cultured in standard and nutrient-stressed conditions and the obtained biomass extracts were assessed for their potential to inhibit cancer cell proliferation and migration as well as their antioxidant activity. Results from viability in 2D and 3D cancer cell models showed an enhancement of the antitumour activity of P. purpureum in the 3D model compared to 2D, together with a greater capacity to reduce the migration capacity of cancer cells with the biomass from nutrient-stressed conditions, whereas the antioxidant activity of N. oculata decreased when exposed to nutrient-stressed conditions. To date, this is one of the few studies that proves that controlled changes in large-scale culturing conditions such as nutrient depletion have a relevant impact in the bioactivity of the biomass on cancer cells. Journal Article Marine Drugs 20 10 627 MDPI AG 1660-3397 microalgae; cancer cells; antitumour; biomass; therapeutic; biotechnology 30 9 2022 2022-09-30 10.3390/md20100627 COLLEGE NANME Medical School COLLEGE CODE MEDS Swansea University Other This project was funded by: Interreg Atlantic Area European Regional development fund, project Enhance Microalgae EAPA_338/2016 (C.F.G). Swansea University Medical School departmental funds (J.G.P. and D.G.), and Ministry of Environment, Water and Agriculture (MEWA) of the Kingdom of Saudi Arabia, project number: 52000003916, Development of Algal Biotechnology in the Kingdom of Saudi Arabia (C.F.G.). 2026-02-09T12:42:15.0997020 2026-01-29T15:15:38.9167746 Faculty of Medicine, Health and Life Sciences Swansea University Medical School - Biomedical Science Jezabel Garcia-Parra 0000-0002-4235-4427 1 Claudio Fuentes-Grünewald 2 Deya Gonzalez 0000-0002-1838-6752 3 71344__36212__33a95505bb0740b58f51018eab39b88b.pdf 71344.VoR.pdf 2026-02-09T12:40:21.8873617 Output 6160166 application/pdf Version of Record true © 2022 by the authors. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license. true eng https://creativecommons.org/licenses/by/4.0/
title Therapeutic Potential of Microalgae-Derived Bioactive Metabolites Is Influenced by Different Large-Scale Culture Strategies
spellingShingle Therapeutic Potential of Microalgae-Derived Bioactive Metabolites Is Influenced by Different Large-Scale Culture Strategies
Deya Gonzalez
title_short Therapeutic Potential of Microalgae-Derived Bioactive Metabolites Is Influenced by Different Large-Scale Culture Strategies
title_full Therapeutic Potential of Microalgae-Derived Bioactive Metabolites Is Influenced by Different Large-Scale Culture Strategies
title_fullStr Therapeutic Potential of Microalgae-Derived Bioactive Metabolites Is Influenced by Different Large-Scale Culture Strategies
title_full_unstemmed Therapeutic Potential of Microalgae-Derived Bioactive Metabolites Is Influenced by Different Large-Scale Culture Strategies
title_sort Therapeutic Potential of Microalgae-Derived Bioactive Metabolites Is Influenced by Different Large-Scale Culture Strategies
author_id_str_mv bafdf635eb81280304eedf4b18e65d4e
author_id_fullname_str_mv bafdf635eb81280304eedf4b18e65d4e_***_Deya Gonzalez
author Deya Gonzalez
author2 Jezabel Garcia-Parra
Claudio Fuentes-Grünewald
Deya Gonzalez
format Journal article
container_title Marine Drugs
container_volume 20
container_issue 10
container_start_page 627
publishDate 2022
institution Swansea University
issn 1660-3397
doi_str_mv 10.3390/md20100627
publisher MDPI AG
college_str Faculty of Medicine, Health and Life Sciences
hierarchytype
hierarchy_top_id facultyofmedicinehealthandlifesciences
hierarchy_top_title Faculty of Medicine, Health and Life Sciences
hierarchy_parent_id facultyofmedicinehealthandlifesciences
hierarchy_parent_title Faculty of Medicine, Health and Life Sciences
department_str Swansea University Medical School - Biomedical Science{{{_:::_}}}Faculty of Medicine, Health and Life Sciences{{{_:::_}}}Swansea University Medical School - Biomedical Science
document_store_str 1
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description Microalgae have been identified as one of the most promising sources of novel bioactive compounds for biomedical applications, the food industry, and cosmetics. In the last decade, several biotechnological developments have facilitated the identification of a growing number of compounds as well as the study of optimal microalgae culture conditions for the production of biomass enriched in specific molecules of interest. In this study, two common commercial marine microalgae (Nannochloropsis oculata and Porphyridium purpureum) were cultured in standard and nutrient-stressed conditions and the obtained biomass extracts were assessed for their potential to inhibit cancer cell proliferation and migration as well as their antioxidant activity. Results from viability in 2D and 3D cancer cell models showed an enhancement of the antitumour activity of P. purpureum in the 3D model compared to 2D, together with a greater capacity to reduce the migration capacity of cancer cells with the biomass from nutrient-stressed conditions, whereas the antioxidant activity of N. oculata decreased when exposed to nutrient-stressed conditions. To date, this is one of the few studies that proves that controlled changes in large-scale culturing conditions such as nutrient depletion have a relevant impact in the bioactivity of the biomass on cancer cells.
published_date 2022-09-30T05:34:35Z
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