Journal article 523 views
Mechanisms of allergic disease - environmental and genetic determinants for the development of allergy / D. E. Campbell; R. J. Boyle; C. A. Thornton; S. L. Prescott; Catherine Thornton
Clinical & Experimental Allergy, Volume: 45, Issue: 5, Pages: 844 - 858
Swansea University Author: Catherine, Thornton
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DOI (Published version): 10.1111/cea.12531
Abstract
Allergic disease can be viewed as an early manifestation of immune dysregulation. Environmental exposures including maternal inflammation, diet, nutrient balance, microbial colonisation and toxin exposures can directly and indirectly influence immune programming in both pregnancy and the postnatal p...
Published in: | Clinical & Experimental Allergy |
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2015
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URI: | https://cronfa.swan.ac.uk/Record/cronfa23515 |
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2015-09-30T12:48:50.7473335 v2 23515 2015-09-30 Mechanisms of allergic disease - environmental and genetic determinants for the development of allergy c71a7a4be7361094d046d312202bce0c 0000-0002-5153-573X Catherine Thornton Catherine Thornton true false 2015-09-30 BMS Allergic disease can be viewed as an early manifestation of immune dysregulation. Environmental exposures including maternal inflammation, diet, nutrient balance, microbial colonisation and toxin exposures can directly and indirectly influence immune programming in both pregnancy and the postnatal period. The intrauterine microclimate is critical for maternal and foetal immunological tolerance to sustain viable pregnancy, but appears susceptible to environmental conditions. Targeting aspects of the modern environment that promote aberrant patterns of immune response is logical for interventions aimed at primary prevention of allergic disease. Defining the mechanisms that underpin both natural and therapeutic acquisition of immunological tolerance in childhood will provide insights into the drivers of persistent immune dysregulation. In this review we summarise evidence that allergy is a consequence of intrauterine and early life immune dysregulation, with specific focus on contributing environmental risk factors occurring preconception, in utero and in the early postnatal period. We explore the immunological mechanisms which underpin tolerance and persistence of allergic disease during childhood. It is likely that future investigations within these two domains will ultimately provide a road map for the primary prevention of allergic disease. Journal Article Clinical & Experimental Allergy 45 5 844 858 31 12 2015 2015-12-31 10.1111/cea.12531 COLLEGE NANME Biomedical Sciences COLLEGE CODE BMS Swansea University 2015-09-30T12:48:50.7473335 2015-09-30T12:30:35.6671138 Swansea University Medical School Medicine D. E. Campbell 1 R. J. Boyle 2 C. A. Thornton 3 S. L. Prescott 4 Catherine Thornton 0000-0002-5153-573X 5 |
title |
Mechanisms of allergic disease - environmental and genetic determinants for the development of allergy |
spellingShingle |
Mechanisms of allergic disease - environmental and genetic determinants for the development of allergy Catherine, Thornton |
title_short |
Mechanisms of allergic disease - environmental and genetic determinants for the development of allergy |
title_full |
Mechanisms of allergic disease - environmental and genetic determinants for the development of allergy |
title_fullStr |
Mechanisms of allergic disease - environmental and genetic determinants for the development of allergy |
title_full_unstemmed |
Mechanisms of allergic disease - environmental and genetic determinants for the development of allergy |
title_sort |
Mechanisms of allergic disease - environmental and genetic determinants for the development of allergy |
author_id_str_mv |
c71a7a4be7361094d046d312202bce0c |
author_id_fullname_str_mv |
c71a7a4be7361094d046d312202bce0c_***_Catherine, Thornton |
author |
Catherine, Thornton |
author2 |
D. E. Campbell R. J. Boyle C. A. Thornton S. L. Prescott Catherine Thornton |
format |
Journal article |
container_title |
Clinical & Experimental Allergy |
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45 |
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5 |
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844 |
publishDate |
2015 |
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Swansea University |
doi_str_mv |
10.1111/cea.12531 |
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Swansea University Medical School |
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swanseauniversitymedicalschool |
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Swansea University Medical School |
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swanseauniversitymedicalschool |
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Swansea University Medical School |
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Medicine{{{_:::_}}}Swansea University Medical School{{{_:::_}}}Medicine |
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description |
Allergic disease can be viewed as an early manifestation of immune dysregulation. Environmental exposures including maternal inflammation, diet, nutrient balance, microbial colonisation and toxin exposures can directly and indirectly influence immune programming in both pregnancy and the postnatal period. The intrauterine microclimate is critical for maternal and foetal immunological tolerance to sustain viable pregnancy, but appears susceptible to environmental conditions. Targeting aspects of the modern environment that promote aberrant patterns of immune response is logical for interventions aimed at primary prevention of allergic disease. Defining the mechanisms that underpin both natural and therapeutic acquisition of immunological tolerance in childhood will provide insights into the drivers of persistent immune dysregulation. In this review we summarise evidence that allergy is a consequence of intrauterine and early life immune dysregulation, with specific focus on contributing environmental risk factors occurring preconception, in utero and in the early postnatal period. We explore the immunological mechanisms which underpin tolerance and persistence of allergic disease during childhood. It is likely that future investigations within these two domains will ultimately provide a road map for the primary prevention of allergic disease. |
published_date |
2015-12-31T03:38:36Z |
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1696800562572427264 |
score |
10.78774 |