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Comorbidities are associated with poorer quality of life and functioning and worse symptoms in the 5 years following colorectal cancer surgery: Results from the ColoREctal Well-being (CREW) cohort study

Amanda Cummings, Chloe Grimmett, Lynn Calman, Mubarak Patel, Natalia Vadimovna Permyakova, Jane Winter, Jessica Corner, Amy Din, Deborah Fenlon, Alison Richardson, Peter W. Smith, Claire Foster

Psycho-Oncology, Volume: 27, Issue: 10, Pages: 2427 - 2435

Swansea University Author: Deborah Fenlon

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DOI (Published version): 10.1002/pon.4845

Abstract

ObjectiveMore people are living with the consequences of cancer and comorbidity. We describe frequencies of comorbidities in a colorectal cancer cohort and associations with health and wellbeing outcomes up to five years following surgery. MethodsProspective cohort study of 872 colorectal cancer pat...

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Published in: Psycho-Oncology
ISSN: 10579249
Published: 2018
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URI: https://cronfa.swan.ac.uk/Record/cronfa41192
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fullrecord <?xml version="1.0"?><rfc1807><datestamp>2019-08-07T10:48:22.6271424</datestamp><bib-version>v2</bib-version><id>41192</id><entry>2018-07-31</entry><title>Comorbidities are associated with poorer quality of life and functioning and worse symptoms in the 5&#xA0;years following colorectal cancer surgery: Results from the ColoREctal Well-being (CREW) cohort study</title><swanseaauthors><author><sid>efa6c181fe0a6e5c923b1126ce469186</sid><firstname>Deborah</firstname><surname>Fenlon</surname><name>Deborah Fenlon</name><active>true</active><ethesisStudent>false</ethesisStudent></author></swanseaauthors><date>2018-07-31</date><deptcode>FGMHL</deptcode><abstract>ObjectiveMore people are living with the consequences of cancer and comorbidity. We describe frequencies of comorbidities in a colorectal cancer cohort and associations with health and wellbeing outcomes up to five years following surgery. MethodsProspective cohort study of 872 colorectal cancer patients recruited 2010-2012 from 29 UK centres, awaiting curative intent surgery. Questionnaires administered at baseline (pre-surgery), 3, 9, 15, 24 months, and annually up to 5 years. Comorbidities (and whether they limit activities) were self-reported by participants from 3 months. The EORTC QLQ-C30 and QLQ-CR29 assessed global health/quality of life (QoL), symptoms and functioning. Longitudinal analyses investigated associations between comorbidities and health and wellbeing outcomes. ResultsAt baseline, the mean age of participants was 68 years, with 60% male and 65% colon cancer. 32% had one and 40% had &gt;2 comorbidities. The most common comorbidities were high blood pressure (43%), arthritis/rheumatism (32%) and anxiety/depression (18%). Of those with comorbidities, 37% reported at least one that limited their daily activities. Reporting any limiting comorbidities was associated with poorer global health/QoL, worse symptoms and poorer functioning on all domains over 5 years&#x2019; follow-up. Controlling for the most common individual comorbidities, depression/anxiety had the greatest deleterious effect on outcomes. ConclusionsClinical assessment should prioritise patient-reported comorbidities and whether these comorbidities limit daily activities, as important determinants of recovery of QoL, symptoms and functioning following colorectal cancer. Targeted interventions and support services, including multi-professional management and tailored assessment and follow-up, may aid recovery of health and wellbeing recovery in these individuals.</abstract><type>Journal Article</type><journal>Psycho-Oncology</journal><volume>27</volume><journalNumber>10</journalNumber><paginationStart>2427</paginationStart><paginationEnd>2435</paginationEnd><publisher/><issnPrint>10579249</issnPrint><keywords>Cancer, Oncology, Colorectal cancer, Comorbidities, Health and wellbeing, Longitudinal, Quality of life, Survivorship</keywords><publishedDay>31</publishedDay><publishedMonth>10</publishedMonth><publishedYear>2018</publishedYear><publishedDate>2018-10-31</publishedDate><doi>10.1002/pon.4845</doi><url/><notes/><college>COLLEGE NANME</college><department>Medicine, Health and Life Science - Faculty</department><CollegeCode>COLLEGE CODE</CollegeCode><DepartmentCode>FGMHL</DepartmentCode><institution>Swansea University</institution><apcterm/><lastEdited>2019-08-07T10:48:22.6271424</lastEdited><Created>2018-07-31T10:18:16.5558964</Created><path><level id="1">Faculty of Medicine, Health and Life Sciences</level><level id="2">School of Health and Social Care - Nursing</level></path><authors><author><firstname>Amanda</firstname><surname>Cummings</surname><order>1</order></author><author><firstname>Chloe</firstname><surname>Grimmett</surname><order>2</order></author><author><firstname>Lynn</firstname><surname>Calman</surname><order>3</order></author><author><firstname>Mubarak</firstname><surname>Patel</surname><order>4</order></author><author><firstname>Natalia Vadimovna</firstname><surname>Permyakova</surname><order>5</order></author><author><firstname>Jane</firstname><surname>Winter</surname><order>6</order></author><author><firstname>Jessica</firstname><surname>Corner</surname><order>7</order></author><author><firstname>Amy</firstname><surname>Din</surname><order>8</order></author><author><firstname>Deborah</firstname><surname>Fenlon</surname><order>9</order></author><author><firstname>Alison</firstname><surname>Richardson</surname><order>10</order></author><author><firstname>Peter W.</firstname><surname>Smith</surname><order>11</order></author><author><firstname>Claire</firstname><surname>Foster</surname><order>12</order></author></authors><documents><document><filename>0041192-04102018094637.pdf</filename><originalFilename>41192VoR.pdf</originalFilename><uploaded>2018-10-04T09:46:37.5670000</uploaded><type>Output</type><contentLength>374702</contentLength><contentType>application/pdf</contentType><version>Version of Record</version><cronfaStatus>true</cronfaStatus><embargoDate>2018-10-04T00:00:00.0000000</embargoDate><documentNotes>This is an open access article under the terms of the Creative Commons Attribution License.</documentNotes><copyrightCorrect>true</copyrightCorrect><language>eng</language></document></documents><OutputDurs/></rfc1807>
spelling 2019-08-07T10:48:22.6271424 v2 41192 2018-07-31 Comorbidities are associated with poorer quality of life and functioning and worse symptoms in the 5 years following colorectal cancer surgery: Results from the ColoREctal Well-being (CREW) cohort study efa6c181fe0a6e5c923b1126ce469186 Deborah Fenlon Deborah Fenlon true false 2018-07-31 FGMHL ObjectiveMore people are living with the consequences of cancer and comorbidity. We describe frequencies of comorbidities in a colorectal cancer cohort and associations with health and wellbeing outcomes up to five years following surgery. MethodsProspective cohort study of 872 colorectal cancer patients recruited 2010-2012 from 29 UK centres, awaiting curative intent surgery. Questionnaires administered at baseline (pre-surgery), 3, 9, 15, 24 months, and annually up to 5 years. Comorbidities (and whether they limit activities) were self-reported by participants from 3 months. The EORTC QLQ-C30 and QLQ-CR29 assessed global health/quality of life (QoL), symptoms and functioning. Longitudinal analyses investigated associations between comorbidities and health and wellbeing outcomes. ResultsAt baseline, the mean age of participants was 68 years, with 60% male and 65% colon cancer. 32% had one and 40% had >2 comorbidities. The most common comorbidities were high blood pressure (43%), arthritis/rheumatism (32%) and anxiety/depression (18%). Of those with comorbidities, 37% reported at least one that limited their daily activities. Reporting any limiting comorbidities was associated with poorer global health/QoL, worse symptoms and poorer functioning on all domains over 5 years’ follow-up. Controlling for the most common individual comorbidities, depression/anxiety had the greatest deleterious effect on outcomes. ConclusionsClinical assessment should prioritise patient-reported comorbidities and whether these comorbidities limit daily activities, as important determinants of recovery of QoL, symptoms and functioning following colorectal cancer. Targeted interventions and support services, including multi-professional management and tailored assessment and follow-up, may aid recovery of health and wellbeing recovery in these individuals. Journal Article Psycho-Oncology 27 10 2427 2435 10579249 Cancer, Oncology, Colorectal cancer, Comorbidities, Health and wellbeing, Longitudinal, Quality of life, Survivorship 31 10 2018 2018-10-31 10.1002/pon.4845 COLLEGE NANME Medicine, Health and Life Science - Faculty COLLEGE CODE FGMHL Swansea University 2019-08-07T10:48:22.6271424 2018-07-31T10:18:16.5558964 Faculty of Medicine, Health and Life Sciences School of Health and Social Care - Nursing Amanda Cummings 1 Chloe Grimmett 2 Lynn Calman 3 Mubarak Patel 4 Natalia Vadimovna Permyakova 5 Jane Winter 6 Jessica Corner 7 Amy Din 8 Deborah Fenlon 9 Alison Richardson 10 Peter W. Smith 11 Claire Foster 12 0041192-04102018094637.pdf 41192VoR.pdf 2018-10-04T09:46:37.5670000 Output 374702 application/pdf Version of Record true 2018-10-04T00:00:00.0000000 This is an open access article under the terms of the Creative Commons Attribution License. true eng
title Comorbidities are associated with poorer quality of life and functioning and worse symptoms in the 5 years following colorectal cancer surgery: Results from the ColoREctal Well-being (CREW) cohort study
spellingShingle Comorbidities are associated with poorer quality of life and functioning and worse symptoms in the 5 years following colorectal cancer surgery: Results from the ColoREctal Well-being (CREW) cohort study
Deborah Fenlon
title_short Comorbidities are associated with poorer quality of life and functioning and worse symptoms in the 5 years following colorectal cancer surgery: Results from the ColoREctal Well-being (CREW) cohort study
title_full Comorbidities are associated with poorer quality of life and functioning and worse symptoms in the 5 years following colorectal cancer surgery: Results from the ColoREctal Well-being (CREW) cohort study
title_fullStr Comorbidities are associated with poorer quality of life and functioning and worse symptoms in the 5 years following colorectal cancer surgery: Results from the ColoREctal Well-being (CREW) cohort study
title_full_unstemmed Comorbidities are associated with poorer quality of life and functioning and worse symptoms in the 5 years following colorectal cancer surgery: Results from the ColoREctal Well-being (CREW) cohort study
title_sort Comorbidities are associated with poorer quality of life and functioning and worse symptoms in the 5 years following colorectal cancer surgery: Results from the ColoREctal Well-being (CREW) cohort study
author_id_str_mv efa6c181fe0a6e5c923b1126ce469186
author_id_fullname_str_mv efa6c181fe0a6e5c923b1126ce469186_***_Deborah Fenlon
author Deborah Fenlon
author2 Amanda Cummings
Chloe Grimmett
Lynn Calman
Mubarak Patel
Natalia Vadimovna Permyakova
Jane Winter
Jessica Corner
Amy Din
Deborah Fenlon
Alison Richardson
Peter W. Smith
Claire Foster
format Journal article
container_title Psycho-Oncology
container_volume 27
container_issue 10
container_start_page 2427
publishDate 2018
institution Swansea University
issn 10579249
doi_str_mv 10.1002/pon.4845
college_str Faculty of Medicine, Health and Life Sciences
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hierarchy_top_id facultyofmedicinehealthandlifesciences
hierarchy_top_title Faculty of Medicine, Health and Life Sciences
hierarchy_parent_id facultyofmedicinehealthandlifesciences
hierarchy_parent_title Faculty of Medicine, Health and Life Sciences
department_str School of Health and Social Care - Nursing{{{_:::_}}}Faculty of Medicine, Health and Life Sciences{{{_:::_}}}School of Health and Social Care - Nursing
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description ObjectiveMore people are living with the consequences of cancer and comorbidity. We describe frequencies of comorbidities in a colorectal cancer cohort and associations with health and wellbeing outcomes up to five years following surgery. MethodsProspective cohort study of 872 colorectal cancer patients recruited 2010-2012 from 29 UK centres, awaiting curative intent surgery. Questionnaires administered at baseline (pre-surgery), 3, 9, 15, 24 months, and annually up to 5 years. Comorbidities (and whether they limit activities) were self-reported by participants from 3 months. The EORTC QLQ-C30 and QLQ-CR29 assessed global health/quality of life (QoL), symptoms and functioning. Longitudinal analyses investigated associations between comorbidities and health and wellbeing outcomes. ResultsAt baseline, the mean age of participants was 68 years, with 60% male and 65% colon cancer. 32% had one and 40% had >2 comorbidities. The most common comorbidities were high blood pressure (43%), arthritis/rheumatism (32%) and anxiety/depression (18%). Of those with comorbidities, 37% reported at least one that limited their daily activities. Reporting any limiting comorbidities was associated with poorer global health/QoL, worse symptoms and poorer functioning on all domains over 5 years’ follow-up. Controlling for the most common individual comorbidities, depression/anxiety had the greatest deleterious effect on outcomes. ConclusionsClinical assessment should prioritise patient-reported comorbidities and whether these comorbidities limit daily activities, as important determinants of recovery of QoL, symptoms and functioning following colorectal cancer. Targeted interventions and support services, including multi-professional management and tailored assessment and follow-up, may aid recovery of health and wellbeing recovery in these individuals.
published_date 2018-10-31T03:52:30Z
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