Conference Paper/Proceeding/Abstract 806 views 63 downloads
Predicting the elastic properties and deformability of red blood cell membrane using an atomistic-continuum approach
Proceedings of the International MultiConference of Engineers and Computer Scientists 2016, Pages: 942 - 946
Swansea University Author:
Adesola Ademiloye
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DOI (Published version): 10.13140/RG.2.1.3088.8082
Abstract
This paper employs the gradient theory to study the elastic properties and deformability of red blood cell (RBC) membrane using the first-order Cauchy-Born rule as an atomistic-continuum hyperelastic constitutive model that directly incorporates the microstructure of the spectrin network. The well-k...
Published in: | Proceedings of the International MultiConference of Engineers and Computer Scientists 2016 |
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ISBN: | 978-988-14047-6-3 |
ISSN: | 2078-0958 2078-0966 |
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Hong Kong
International MultiConference of Engineers and Computer Scientists 2016
2016
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URI: | https://cronfa.swan.ac.uk/Record/cronfa44912 |
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2019-01-14T11:48:37.2249224 v2 44912 2018-10-16 Predicting the elastic properties and deformability of red blood cell membrane using an atomistic-continuum approach e37960ed89a7e3eaeba2201762626594 0000-0002-9741-6488 Adesola Ademiloye Adesola Ademiloye true false 2018-10-16 MEDE This paper employs the gradient theory to study the elastic properties and deformability of red blood cell (RBC) membrane using the first-order Cauchy-Born rule as an atomistic-continuum hyperelastic constitutive model that directly incorporates the microstructure of the spectrin network. The well-known Cauchy-Born rule is extended to account for a three-dimensional (3D) reference configuration. Using the strain energy density function and the deformation gradient tensor, the elastic properties of the RBC membrane were predicted by minimizing the potential energy in the representative cell. This extended formulation was then coupled with the meshfree method for numerical modeling of the finite deformation of the RBC membrane by simulating the optical tweezer experiment using a self-written MATLAB code. The results obtained provide new insight into the elastic properties and deformability of RBC membrane. In addition, the proposed method performs better when compared with those found in literature in terms of prediction accuracy and computation efficiency. Conference Paper/Proceeding/Abstract Proceedings of the International MultiConference of Engineers and Computer Scientists 2016 942 946 International MultiConference of Engineers and Computer Scientists 2016 Hong Kong 978-988-14047-6-3 2078-0958 2078-0966 31 3 2016 2016-03-31 10.13140/RG.2.1.3088.8082 http://www.iaeng.org/publication/IMECS2016/IMECS2016_pp947-952.pdf COLLEGE NANME Biomedical Engineering COLLEGE CODE MEDE Swansea University 2019-01-14T11:48:37.2249224 2018-10-16T12:47:51.7948573 Faculty of Science and Engineering School of Engineering and Applied Sciences - Biomedical Engineering Adesola Ademiloye 0000-0002-9741-6488 1 L.W. Zhang 2 K.M. Liew 3 0044912-12112018150606.pdf ademiloye2016(2).pdf 2018-11-12T15:06:06.8500000 Output 1311208 application/pdf Version of Record true 2018-11-12T00:00:00.0000000 true eng |
title |
Predicting the elastic properties and deformability of red blood cell membrane using an atomistic-continuum approach |
spellingShingle |
Predicting the elastic properties and deformability of red blood cell membrane using an atomistic-continuum approach Adesola Ademiloye |
title_short |
Predicting the elastic properties and deformability of red blood cell membrane using an atomistic-continuum approach |
title_full |
Predicting the elastic properties and deformability of red blood cell membrane using an atomistic-continuum approach |
title_fullStr |
Predicting the elastic properties and deformability of red blood cell membrane using an atomistic-continuum approach |
title_full_unstemmed |
Predicting the elastic properties and deformability of red blood cell membrane using an atomistic-continuum approach |
title_sort |
Predicting the elastic properties and deformability of red blood cell membrane using an atomistic-continuum approach |
author_id_str_mv |
e37960ed89a7e3eaeba2201762626594 |
author_id_fullname_str_mv |
e37960ed89a7e3eaeba2201762626594_***_Adesola Ademiloye |
author |
Adesola Ademiloye |
author2 |
Adesola Ademiloye L.W. Zhang K.M. Liew |
format |
Conference Paper/Proceeding/Abstract |
container_title |
Proceedings of the International MultiConference of Engineers and Computer Scientists 2016 |
container_start_page |
942 |
publishDate |
2016 |
institution |
Swansea University |
isbn |
978-988-14047-6-3 |
issn |
2078-0958 2078-0966 |
doi_str_mv |
10.13140/RG.2.1.3088.8082 |
publisher |
International MultiConference of Engineers and Computer Scientists 2016 |
college_str |
Faculty of Science and Engineering |
hierarchytype |
|
hierarchy_top_id |
facultyofscienceandengineering |
hierarchy_top_title |
Faculty of Science and Engineering |
hierarchy_parent_id |
facultyofscienceandengineering |
hierarchy_parent_title |
Faculty of Science and Engineering |
department_str |
School of Engineering and Applied Sciences - Biomedical Engineering{{{_:::_}}}Faculty of Science and Engineering{{{_:::_}}}School of Engineering and Applied Sciences - Biomedical Engineering |
url |
http://www.iaeng.org/publication/IMECS2016/IMECS2016_pp947-952.pdf |
document_store_str |
1 |
active_str |
0 |
description |
This paper employs the gradient theory to study the elastic properties and deformability of red blood cell (RBC) membrane using the first-order Cauchy-Born rule as an atomistic-continuum hyperelastic constitutive model that directly incorporates the microstructure of the spectrin network. The well-known Cauchy-Born rule is extended to account for a three-dimensional (3D) reference configuration. Using the strain energy density function and the deformation gradient tensor, the elastic properties of the RBC membrane were predicted by minimizing the potential energy in the representative cell. This extended formulation was then coupled with the meshfree method for numerical modeling of the finite deformation of the RBC membrane by simulating the optical tweezer experiment using a self-written MATLAB code. The results obtained provide new insight into the elastic properties and deformability of RBC membrane. In addition, the proposed method performs better when compared with those found in literature in terms of prediction accuracy and computation efficiency. |
published_date |
2016-03-31T03:56:24Z |
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1763752840317108224 |
score |
11.021648 |