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Sterolomics in biology, biochemistry, medicine

William Griffiths Orcid Logo, Yuqin Wang Orcid Logo

TrAC Trends in Analytical Chemistry, Volume: 120, Start page: 115280

Swansea University Authors: William Griffiths Orcid Logo, Yuqin Wang Orcid Logo

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DOI (Published version): 10.1016/j.trac.2018.10.016

Abstract

In mammalian systems “sterolomics” can be regarded as the quantitative or semi-quantitative profiling of all metabolites derived from cholesterol and its cyclic precursors. The system can be further complicated by metabolites derived from ingested phytosterols or pharmaceuticals, but this is beyond...

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Published in: TrAC Trends in Analytical Chemistry
ISSN: 0165-9936
Published: Elsevier BV 2019
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URI: https://cronfa.swan.ac.uk/Record/cronfa45237
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first_indexed 2018-10-26T13:18:04Z
last_indexed 2019-09-24T20:07:14Z
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spelling 2019-09-24T15:19:16.5874636 v2 45237 2018-10-26 Sterolomics in biology, biochemistry, medicine 3316b1d1b524be1831790933eed1c26e 0000-0002-4129-6616 William Griffiths William Griffiths true false c92729b58622f9fdf6a0e7d8f4ce5081 0000-0002-3063-3066 Yuqin Wang Yuqin Wang true false 2018-10-26 BMS In mammalian systems “sterolomics” can be regarded as the quantitative or semi-quantitative profiling of all metabolites derived from cholesterol and its cyclic precursors. The system can be further complicated by metabolites derived from ingested phytosterols or pharmaceuticals, but this is beyond the scope of this article. “Sterolomics” can be performed on either an unbiased global format, or more usually, exploiting a targeted format. Here we discuss the different mass spectrometry-based analytical techniques used in “sterolomics” giving specific examples in the context of neurodegenerative disease and for the diagnosis of inborn errors of metabolism. We pay particular attention to the profiling of cholesterol metabolites in the bile acid biosynthesis pathways, although the analytical techniques discussed are also appropriate for analysis of hormonal steroids. Journal Article TrAC Trends in Analytical Chemistry 120 115280 Elsevier BV 0165-9936 Mass spectrometry, liquid chromatography – mass spectrometry, gas chromatography – mass spectrometry, Alzheimer’s disease, Niemann Pick disease, inborn errors of metabolism, bile acids, oxysterols 30 11 2019 2019-11-30 10.1016/j.trac.2018.10.016 COLLEGE NANME Biomedical Sciences COLLEGE CODE BMS Swansea University RCUK, BB/I001735/1 2019-09-24T15:19:16.5874636 2018-10-26T08:28:29.8396961 Faculty of Medicine, Health and Life Sciences Swansea University Medical School - Medicine William Griffiths 0000-0002-4129-6616 1 Yuqin Wang 0000-0002-3063-3066 2 45237__16003__6b26486f6d9c4a28a44fb805a1e49f97.pdf 45237.pdf 2019-11-29T16:49:57.8974172 Output 1380671 application/pdf Version of Record true Released under the terms of a Creative Commons Attribution License (CC-BY). true https://creativecommons.org/licenses/by/4.0/
title Sterolomics in biology, biochemistry, medicine
spellingShingle Sterolomics in biology, biochemistry, medicine
William Griffiths
Yuqin Wang
title_short Sterolomics in biology, biochemistry, medicine
title_full Sterolomics in biology, biochemistry, medicine
title_fullStr Sterolomics in biology, biochemistry, medicine
title_full_unstemmed Sterolomics in biology, biochemistry, medicine
title_sort Sterolomics in biology, biochemistry, medicine
author_id_str_mv 3316b1d1b524be1831790933eed1c26e
c92729b58622f9fdf6a0e7d8f4ce5081
author_id_fullname_str_mv 3316b1d1b524be1831790933eed1c26e_***_William Griffiths
c92729b58622f9fdf6a0e7d8f4ce5081_***_Yuqin Wang
author William Griffiths
Yuqin Wang
author2 William Griffiths
Yuqin Wang
format Journal article
container_title TrAC Trends in Analytical Chemistry
container_volume 120
container_start_page 115280
publishDate 2019
institution Swansea University
issn 0165-9936
doi_str_mv 10.1016/j.trac.2018.10.016
publisher Elsevier BV
college_str Faculty of Medicine, Health and Life Sciences
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hierarchy_top_id facultyofmedicinehealthandlifesciences
hierarchy_top_title Faculty of Medicine, Health and Life Sciences
hierarchy_parent_id facultyofmedicinehealthandlifesciences
hierarchy_parent_title Faculty of Medicine, Health and Life Sciences
department_str Swansea University Medical School - Medicine{{{_:::_}}}Faculty of Medicine, Health and Life Sciences{{{_:::_}}}Swansea University Medical School - Medicine
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description In mammalian systems “sterolomics” can be regarded as the quantitative or semi-quantitative profiling of all metabolites derived from cholesterol and its cyclic precursors. The system can be further complicated by metabolites derived from ingested phytosterols or pharmaceuticals, but this is beyond the scope of this article. “Sterolomics” can be performed on either an unbiased global format, or more usually, exploiting a targeted format. Here we discuss the different mass spectrometry-based analytical techniques used in “sterolomics” giving specific examples in the context of neurodegenerative disease and for the diagnosis of inborn errors of metabolism. We pay particular attention to the profiling of cholesterol metabolites in the bile acid biosynthesis pathways, although the analytical techniques discussed are also appropriate for analysis of hormonal steroids.
published_date 2019-11-30T03:56:56Z
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score 11.016235

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