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Correlating Local Volumetric Tissue Strains with Global Lung Mechanics Measurements

Hari Arora Orcid Logo, Ria Mitchell Orcid Logo, Richard Johnston Orcid Logo, Marinos Manolesos, David Howells, Joseph Sherwood, Andrew Bodey, Kaz Wanelik

Materials, Volume: 14, Issue: 2, Start page: 439

Swansea University Authors: Hari Arora Orcid Logo, Ria Mitchell Orcid Logo, Richard Johnston Orcid Logo, Marinos Manolesos, David Howells

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DOI (Published version): 10.3390/ma14020439

Abstract

Abstract: The mechanics of breathing is a fascinating and vital process. The lung has complexities andsubtle heterogeneities in structure across length scales that influence mechanics and function. Thisstudy establishes an experimental pipeline for capturing alveolar deformations during a respirator...

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Published in: Materials
ISSN: 1996-1944
Published: MDPI AG 2021
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The lung has complexities andsubtle heterogeneities in structure across length scales that influence mechanics and function. Thisstudy establishes an experimental pipeline for capturing alveolar deformations during a respiratorycycle using synchrotron radiation micro-computed tomography (SR-micro-CT). Rodent lungs weremechanically ventilated and imaged at various time points during the respiratory cycle. PressureVolume (P-V) characteristics were recorded to capture any changes in overall lung mechanicalbehaviour during the experiment. A sequence of tomograms was collected from the lungs within theintact thoracic cavity. Digital volume correlation (DVC) was used to compute the three-dimensionalstrain field at the alveolar level from the time sequence of reconstructed tomograms. Regionaldifferences in ventilation were highlighted during the respiratory cycle, relating the local strainswithin the lung tissue to the global ventilation measurements. Strains locally reached approximately150% compared to the averaged regional deformations of approximately 80&#x2013;100%. Redistribution ofair within the lungs was observed during cycling. Regions which were relatively poorly ventilated(low deformations compared to its neighbouring region) were deforming more uniformly at laterstages of the experiment (consistent with its neighbouring region). Such heterogenous phenomena arecommon in everyday breathing. In pathological lungs, some of these non-uniformities in deformationbehaviour can become exaggerated, leading to poor function or further damage. The techniquepresented can help characterize the multiscale biomechanical nature of a given pathology to improvepatient management strategies, considering both the local and global lung mechanics.</abstract><type>Journal Article</type><journal>Materials</journal><volume>14</volume><journalNumber>2</journalNumber><paginationStart>439</paginationStart><paginationEnd/><publisher>MDPI AG</publisher><placeOfPublication/><isbnPrint/><isbnElectronic/><issnPrint/><issnElectronic>1996-1944</issnElectronic><keywords>lung mechanics; micro-CT; synchrotron; digital volume correlation; alveoli</keywords><publishedDay>18</publishedDay><publishedMonth>1</publishedMonth><publishedYear>2021</publishedYear><publishedDate>2021-01-18</publishedDate><doi>10.3390/ma14020439</doi><url/><notes/><college>COLLEGE NANME</college><department>Biomedical Engineering</department><CollegeCode>COLLEGE CODE</CollegeCode><DepartmentCode>MEDE</DepartmentCode><institution>Swansea University</institution><apcterm/><funders>UKRI Block Grant, EP/M028267/1</funders><lastEdited>2021-02-19T09:01:49.8436993</lastEdited><Created>2021-01-21T14:03:17.0688421</Created><path><level id="1">Faculty of Science and Engineering</level><level id="2">School of Engineering and Applied Sciences - Materials Science and Engineering</level></path><authors><author><firstname>Hari</firstname><surname>Arora</surname><orcid>0000-0002-9790-0907</orcid><order>1</order></author><author><firstname>Ria</firstname><surname>Mitchell</surname><orcid>0000-0002-6328-3998</orcid><order>2</order></author><author><firstname>Richard</firstname><surname>Johnston</surname><orcid>0000-0003-1977-6418</orcid><order>3</order></author><author><firstname>Marinos</firstname><surname>Manolesos</surname><order>4</order></author><author><firstname>David</firstname><surname>Howells</surname><order>5</order></author><author><firstname>Joseph</firstname><surname>Sherwood</surname><order>6</order></author><author><firstname>Andrew</firstname><surname>Bodey</surname><order>7</order></author><author><firstname>Kaz</firstname><surname>Wanelik</surname><order>8</order></author></authors><documents><document><filename>56090__19145__6f4254334fa347c4aa0c1b46a645327e.pdf</filename><originalFilename>materials-14-00439.pdf</originalFilename><uploaded>2021-01-21T14:08:49.5311720</uploaded><type>Output</type><contentLength>11833144</contentLength><contentType>application/pdf</contentType><version>Version of Record</version><cronfaStatus>true</cronfaStatus><documentNotes>Copyright: &#xA9; 2021 by the authors. 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spelling 2021-02-19T09:01:49.8436993 v2 56090 2021-01-21 Correlating Local Volumetric Tissue Strains with Global Lung Mechanics Measurements ed7371c768e9746008a6807f9f7a1555 0000-0002-9790-0907 Hari Arora Hari Arora true false fcfffafbafb0036c483338f839df45e5 0000-0002-6328-3998 Ria Mitchell Ria Mitchell true false 23282e7acce87dd926b8a62ae410a393 0000-0003-1977-6418 Richard Johnston Richard Johnston true false 44a3e0d351ccd7a8365d5fc7c50c8778 Marinos Manolesos Marinos Manolesos true false 1e204d7456909eaa1bcd19f5d7415134 David Howells David Howells true false 2021-01-21 MEDE Abstract: The mechanics of breathing is a fascinating and vital process. The lung has complexities andsubtle heterogeneities in structure across length scales that influence mechanics and function. Thisstudy establishes an experimental pipeline for capturing alveolar deformations during a respiratorycycle using synchrotron radiation micro-computed tomography (SR-micro-CT). Rodent lungs weremechanically ventilated and imaged at various time points during the respiratory cycle. PressureVolume (P-V) characteristics were recorded to capture any changes in overall lung mechanicalbehaviour during the experiment. A sequence of tomograms was collected from the lungs within theintact thoracic cavity. Digital volume correlation (DVC) was used to compute the three-dimensionalstrain field at the alveolar level from the time sequence of reconstructed tomograms. Regionaldifferences in ventilation were highlighted during the respiratory cycle, relating the local strainswithin the lung tissue to the global ventilation measurements. Strains locally reached approximately150% compared to the averaged regional deformations of approximately 80–100%. Redistribution ofair within the lungs was observed during cycling. Regions which were relatively poorly ventilated(low deformations compared to its neighbouring region) were deforming more uniformly at laterstages of the experiment (consistent with its neighbouring region). Such heterogenous phenomena arecommon in everyday breathing. In pathological lungs, some of these non-uniformities in deformationbehaviour can become exaggerated, leading to poor function or further damage. The techniquepresented can help characterize the multiscale biomechanical nature of a given pathology to improvepatient management strategies, considering both the local and global lung mechanics. Journal Article Materials 14 2 439 MDPI AG 1996-1944 lung mechanics; micro-CT; synchrotron; digital volume correlation; alveoli 18 1 2021 2021-01-18 10.3390/ma14020439 COLLEGE NANME Biomedical Engineering COLLEGE CODE MEDE Swansea University UKRI Block Grant, EP/M028267/1 2021-02-19T09:01:49.8436993 2021-01-21T14:03:17.0688421 Faculty of Science and Engineering School of Engineering and Applied Sciences - Materials Science and Engineering Hari Arora 0000-0002-9790-0907 1 Ria Mitchell 0000-0002-6328-3998 2 Richard Johnston 0000-0003-1977-6418 3 Marinos Manolesos 4 David Howells 5 Joseph Sherwood 6 Andrew Bodey 7 Kaz Wanelik 8 56090__19145__6f4254334fa347c4aa0c1b46a645327e.pdf materials-14-00439.pdf 2021-01-21T14:08:49.5311720 Output 11833144 application/pdf Version of Record true Copyright: © 2021 by the authors. Distributed under the terms of a Creative Commons Attribution 4.0 (CC-BY)License. true eng https://creativecommons.org/licenses/by/4.0/
title Correlating Local Volumetric Tissue Strains with Global Lung Mechanics Measurements
spellingShingle Correlating Local Volumetric Tissue Strains with Global Lung Mechanics Measurements
Hari Arora
Ria Mitchell
Richard Johnston
Marinos Manolesos
David Howells
title_short Correlating Local Volumetric Tissue Strains with Global Lung Mechanics Measurements
title_full Correlating Local Volumetric Tissue Strains with Global Lung Mechanics Measurements
title_fullStr Correlating Local Volumetric Tissue Strains with Global Lung Mechanics Measurements
title_full_unstemmed Correlating Local Volumetric Tissue Strains with Global Lung Mechanics Measurements
title_sort Correlating Local Volumetric Tissue Strains with Global Lung Mechanics Measurements
author_id_str_mv ed7371c768e9746008a6807f9f7a1555
fcfffafbafb0036c483338f839df45e5
23282e7acce87dd926b8a62ae410a393
44a3e0d351ccd7a8365d5fc7c50c8778
1e204d7456909eaa1bcd19f5d7415134
author_id_fullname_str_mv ed7371c768e9746008a6807f9f7a1555_***_Hari Arora
fcfffafbafb0036c483338f839df45e5_***_Ria Mitchell
23282e7acce87dd926b8a62ae410a393_***_Richard Johnston
44a3e0d351ccd7a8365d5fc7c50c8778_***_Marinos Manolesos
1e204d7456909eaa1bcd19f5d7415134_***_David Howells
author Hari Arora
Ria Mitchell
Richard Johnston
Marinos Manolesos
David Howells
author2 Hari Arora
Ria Mitchell
Richard Johnston
Marinos Manolesos
David Howells
Joseph Sherwood
Andrew Bodey
Kaz Wanelik
format Journal article
container_title Materials
container_volume 14
container_issue 2
container_start_page 439
publishDate 2021
institution Swansea University
issn 1996-1944
doi_str_mv 10.3390/ma14020439
publisher MDPI AG
college_str Faculty of Science and Engineering
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hierarchy_top_id facultyofscienceandengineering
hierarchy_top_title Faculty of Science and Engineering
hierarchy_parent_id facultyofscienceandengineering
hierarchy_parent_title Faculty of Science and Engineering
department_str School of Engineering and Applied Sciences - Materials Science and Engineering{{{_:::_}}}Faculty of Science and Engineering{{{_:::_}}}School of Engineering and Applied Sciences - Materials Science and Engineering
document_store_str 1
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description Abstract: The mechanics of breathing is a fascinating and vital process. The lung has complexities andsubtle heterogeneities in structure across length scales that influence mechanics and function. Thisstudy establishes an experimental pipeline for capturing alveolar deformations during a respiratorycycle using synchrotron radiation micro-computed tomography (SR-micro-CT). Rodent lungs weremechanically ventilated and imaged at various time points during the respiratory cycle. PressureVolume (P-V) characteristics were recorded to capture any changes in overall lung mechanicalbehaviour during the experiment. A sequence of tomograms was collected from the lungs within theintact thoracic cavity. Digital volume correlation (DVC) was used to compute the three-dimensionalstrain field at the alveolar level from the time sequence of reconstructed tomograms. Regionaldifferences in ventilation were highlighted during the respiratory cycle, relating the local strainswithin the lung tissue to the global ventilation measurements. Strains locally reached approximately150% compared to the averaged regional deformations of approximately 80–100%. Redistribution ofair within the lungs was observed during cycling. Regions which were relatively poorly ventilated(low deformations compared to its neighbouring region) were deforming more uniformly at laterstages of the experiment (consistent with its neighbouring region). Such heterogenous phenomena arecommon in everyday breathing. In pathological lungs, some of these non-uniformities in deformationbehaviour can become exaggerated, leading to poor function or further damage. The techniquepresented can help characterize the multiscale biomechanical nature of a given pathology to improvepatient management strategies, considering both the local and global lung mechanics.
published_date 2021-01-18T04:07:18Z
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