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Biomechanics of cells and subcellular components: A comprehensive review of computational models and applications

Chengyuan Wang Orcid Logo, Si Li Orcid Logo, Adesola Ademiloye Orcid Logo, Perumal Nithiarasu Orcid Logo

International Journal for Numerical Methods in Biomedical Engineering, Volume: 37, Issue: 12

Swansea University Authors: Chengyuan Wang Orcid Logo, Si Li Orcid Logo, Adesola Ademiloye Orcid Logo, Perumal Nithiarasu Orcid Logo

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DOI (Published version): 10.1002/cnm.3520

Abstract

Cells are a fundamental structural, functional and biological unit for all living organisms. Up till now, considerable efforts have been made to study the responses of single cells and subcellular components to an external load, and understand the biophysics underlying cell rheology, mechanotransduc...

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Published in: International Journal for Numerical Methods in Biomedical Engineering
ISSN: 2040-7939 2040-7947
Published: Wiley 2021
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URI: https://cronfa.swan.ac.uk/Record/cronfa57696
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Up till now, considerable efforts have been made to study the responses of single cells and subcellular components to an external load, and understand the biophysics underlying cell rheology, mechanotransduction and cell functions using experimental and in silico approaches. In the last decade, computational simulation has become increasingly attractive due to its critical role in interpreting experimental data, analysing complex cellular/subcellular structures, facilitating diagnostic designs and therapeutic techniques, and developing biomimetic materials. Despite the significant progress, developing comprehensive and accurate models of living cells remains a grand challenge in the 21st century. To understand current state of the art, this review summarises and classifies the vast array of computational biomechanical models for cells. The article covers the cellular components at multi-spatial levels, that is, protein polymers, subcellular components, whole cells and the systems with scale beyond a cell. In addition to the comprehensive review of the topic, this article also provides new insights into the future prospects of developing integrated, active and high-fidelity cell models that are multiscale, multi-physics and multi-disciplinary in nature. 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spelling 2022-01-04T15:42:33.8730494 v2 57696 2021-08-27 Biomechanics of cells and subcellular components: A comprehensive review of computational models and applications fdea93ab99f51d0b3921d3601876c1e5 0000-0002-1001-2537 Chengyuan Wang Chengyuan Wang true false 8a27ca9d4a7fb3dfea7627c2ad67424b 0000-0001-6214-9028 Si Li Si Li true false e37960ed89a7e3eaeba2201762626594 0000-0002-9741-6488 Adesola Ademiloye Adesola Ademiloye true false 3b28bf59358fc2b9bd9a46897dbfc92d 0000-0002-4901-2980 Perumal Nithiarasu Perumal Nithiarasu true false 2021-08-27 MECH Cells are a fundamental structural, functional and biological unit for all living organisms. Up till now, considerable efforts have been made to study the responses of single cells and subcellular components to an external load, and understand the biophysics underlying cell rheology, mechanotransduction and cell functions using experimental and in silico approaches. In the last decade, computational simulation has become increasingly attractive due to its critical role in interpreting experimental data, analysing complex cellular/subcellular structures, facilitating diagnostic designs and therapeutic techniques, and developing biomimetic materials. Despite the significant progress, developing comprehensive and accurate models of living cells remains a grand challenge in the 21st century. To understand current state of the art, this review summarises and classifies the vast array of computational biomechanical models for cells. The article covers the cellular components at multi-spatial levels, that is, protein polymers, subcellular components, whole cells and the systems with scale beyond a cell. In addition to the comprehensive review of the topic, this article also provides new insights into the future prospects of developing integrated, active and high-fidelity cell models that are multiscale, multi-physics and multi-disciplinary in nature. This review will be beneficial for the researchers in modelling the biomechanics of subcellular components, cells and multiple cell systems and understanding the cell functions and biological processes from the perspective of cell mechanics. Journal Article International Journal for Numerical Methods in Biomedical Engineering 37 12 Wiley 2040-7939 2040-7947 protein filaments, subcellular components, cells, systems beyond a cell, biomechanical models 23 8 2021 2021-08-23 10.1002/cnm.3520 COLLEGE NANME Mechanical Engineering COLLEGE CODE MECH Swansea University 2022-01-04T15:42:33.8730494 2021-08-27T11:13:07.4778898 Faculty of Science and Engineering School of Aerospace, Civil, Electrical, General and Mechanical Engineering - Civil Engineering Chengyuan Wang 0000-0002-1001-2537 1 Si Li 0000-0001-6214-9028 2 Adesola Ademiloye 0000-0002-9741-6488 3 Perumal Nithiarasu 0000-0002-4901-2980 4 57696__20706__4a64da70f4e14d2b92053c731a8fa970.pdf 57696.pdf 2021-08-27T13:48:31.4131654 Output 1738256 application/pdf Accepted Manuscript true 2022-08-13T00:00:00.0000000 true eng https://creativecommons.org/licenses/by-nc-nd/2.0/
title Biomechanics of cells and subcellular components: A comprehensive review of computational models and applications
spellingShingle Biomechanics of cells and subcellular components: A comprehensive review of computational models and applications
Chengyuan Wang
Si Li
Adesola Ademiloye
Perumal Nithiarasu
title_short Biomechanics of cells and subcellular components: A comprehensive review of computational models and applications
title_full Biomechanics of cells and subcellular components: A comprehensive review of computational models and applications
title_fullStr Biomechanics of cells and subcellular components: A comprehensive review of computational models and applications
title_full_unstemmed Biomechanics of cells and subcellular components: A comprehensive review of computational models and applications
title_sort Biomechanics of cells and subcellular components: A comprehensive review of computational models and applications
author_id_str_mv fdea93ab99f51d0b3921d3601876c1e5
8a27ca9d4a7fb3dfea7627c2ad67424b
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3b28bf59358fc2b9bd9a46897dbfc92d
author_id_fullname_str_mv fdea93ab99f51d0b3921d3601876c1e5_***_Chengyuan Wang
8a27ca9d4a7fb3dfea7627c2ad67424b_***_Si Li
e37960ed89a7e3eaeba2201762626594_***_Adesola Ademiloye
3b28bf59358fc2b9bd9a46897dbfc92d_***_Perumal Nithiarasu
author Chengyuan Wang
Si Li
Adesola Ademiloye
Perumal Nithiarasu
author2 Chengyuan Wang
Si Li
Adesola Ademiloye
Perumal Nithiarasu
format Journal article
container_title International Journal for Numerical Methods in Biomedical Engineering
container_volume 37
container_issue 12
publishDate 2021
institution Swansea University
issn 2040-7939
2040-7947
doi_str_mv 10.1002/cnm.3520
publisher Wiley
college_str Faculty of Science and Engineering
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hierarchy_top_id facultyofscienceandengineering
hierarchy_top_title Faculty of Science and Engineering
hierarchy_parent_id facultyofscienceandengineering
hierarchy_parent_title Faculty of Science and Engineering
department_str School of Aerospace, Civil, Electrical, General and Mechanical Engineering - Civil Engineering{{{_:::_}}}Faculty of Science and Engineering{{{_:::_}}}School of Aerospace, Civil, Electrical, General and Mechanical Engineering - Civil Engineering
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description Cells are a fundamental structural, functional and biological unit for all living organisms. Up till now, considerable efforts have been made to study the responses of single cells and subcellular components to an external load, and understand the biophysics underlying cell rheology, mechanotransduction and cell functions using experimental and in silico approaches. In the last decade, computational simulation has become increasingly attractive due to its critical role in interpreting experimental data, analysing complex cellular/subcellular structures, facilitating diagnostic designs and therapeutic techniques, and developing biomimetic materials. Despite the significant progress, developing comprehensive and accurate models of living cells remains a grand challenge in the 21st century. To understand current state of the art, this review summarises and classifies the vast array of computational biomechanical models for cells. The article covers the cellular components at multi-spatial levels, that is, protein polymers, subcellular components, whole cells and the systems with scale beyond a cell. In addition to the comprehensive review of the topic, this article also provides new insights into the future prospects of developing integrated, active and high-fidelity cell models that are multiscale, multi-physics and multi-disciplinary in nature. This review will be beneficial for the researchers in modelling the biomechanics of subcellular components, cells and multiple cell systems and understanding the cell functions and biological processes from the perspective of cell mechanics.
published_date 2021-08-23T04:13:37Z
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