Journal article 591 views 51 downloads
Remote testing of vitamin D levels across the UK MS population—A case control study
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Siddharthan Chandran,
Niall John James MacDougall,
Gavin Giovannoni,
Ruth Dobson
PLOS ONE, Volume: 15, Issue: 12, Start page: e0241459
Swansea University Author:
Rod Middleton
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© 2020 Vickaryous et al. This is an open access article distributed under the terms of the Creative Commons Attribution License
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DOI (Published version): 10.1371/journal.pone.0241459
Abstract
ObjectiveThe association between vitamin D deficiency and multiple sclerosis (MS) is well described. We set out to use remote sampling to ascertain vitamin D status and vitamin D supplementation in a cross-sectional study of people with MS across the UK.MethodsPeople with MS and matched controls wer...
| Published in: | PLOS ONE |
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| ISSN: | 1932-6203 |
| Published: |
Public Library of Science (PLoS)
2020
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| Online Access: |
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| URI: | https://cronfa.swan.ac.uk/Record/cronfa61487 |
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| Abstract: |
ObjectiveThe association between vitamin D deficiency and multiple sclerosis (MS) is well described. We set out to use remote sampling to ascertain vitamin D status and vitamin D supplementation in a cross-sectional study of people with MS across the UK.MethodsPeople with MS and matched controls were recruited from across the UK. 1768 people with MS enrolled in the study; remote sampling kits were distributed to a subgroup. Dried blood spots (DBS) were used to assess serum 25(OH)D in people with MS and controls.Results1768 MS participants completed the questionnaire; 388 MS participants and 309 controls provided biological samples. Serum 25(OH)D was higher in MS than controls (median 71nmol/L vs 49nmol/L). A higher proportion of MS participants than controls supplemented (72% vs 26%, p<0.001); people with MS supplemented at higher vD doses than controls (median 1600 vs 600 IU/day, p<0.001). People with MS who did not supplement had lower serum 25(OH)D levels than non-supplementing controls (median 38 nmol/L vs 44 nmol/L). Participants engaged well with remote sampling.ConclusionsThe UK MS population have higher serum 25(OH)D than controls, mainly as a result of vitamin D supplementation. Remote sampling is a feasible way of carrying out large studies. |
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| College: |
Faculty of Medicine, Health and Life Sciences |
| Funders: |
This study was funded by the UK MS Society. The work was performed on the Preventive Neurology Unit, which is funded by Barts Charity. |
| Issue: |
12 |
| Start Page: |
e0241459 |