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Remote testing of vitamin D levels across the UK MS population—A case control study

Nicola Vickaryous, Mark Jitlal, Benjamin Meir Jacobs, Rod Middleton Orcid Logo, Siddharthan Chandran, Niall John James MacDougall, Gavin Giovannoni, Ruth Dobson Orcid Logo

PLOS ONE, Volume: 15, Issue: 12, Start page: e0241459

Swansea University Author: Rod Middleton Orcid Logo

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DOI (Published version): 10.1371/journal.pone.0241459

Abstract

ObjectiveThe association between vitamin D deficiency and multiple sclerosis (MS) is well described. We set out to use remote sampling to ascertain vitamin D status and vitamin D supplementation in a cross-sectional study of people with MS across the UK.MethodsPeople with MS and matched controls wer...

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ISSN: 1932-6203
Published: Public Library of Science (PLoS) 2020
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URI: https://cronfa.swan.ac.uk/Record/cronfa61487
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fullrecord <?xml version="1.0"?><rfc1807><datestamp>2022-10-20T14:42:47.2162338</datestamp><bib-version>v2</bib-version><id>61487</id><entry>2022-10-07</entry><title>Remote testing of vitamin D levels across the UK MS population&#x2014;A case control study</title><swanseaauthors><author><sid>005518f819ef1a2a13fdf438529bdfcd</sid><ORCID>0000-0002-2130-4420</ORCID><firstname>Rod</firstname><surname>Middleton</surname><name>Rod Middleton</name><active>true</active><ethesisStudent>false</ethesisStudent></author></swanseaauthors><date>2022-10-07</date><deptcode>HDAT</deptcode><abstract>ObjectiveThe association between vitamin D deficiency and multiple sclerosis (MS) is well described. We set out to use remote sampling to ascertain vitamin D status and vitamin D supplementation in a cross-sectional study of people with MS across the UK.MethodsPeople with MS and matched controls were recruited from across the UK. 1768 people with MS enrolled in the study; remote sampling kits were distributed to a subgroup. Dried blood spots (DBS) were used to assess serum 25(OH)D in people with MS and controls.Results1768 MS participants completed the questionnaire; 388 MS participants and 309 controls provided biological samples. Serum 25(OH)D was higher in MS than controls (median 71nmol/L vs 49nmol/L). A higher proportion of MS participants than controls supplemented (72% vs 26%, p&lt;0.001); people with MS supplemented at higher vD doses than controls (median 1600 vs 600 IU/day, p&lt;0.001). People with MS who did not supplement had lower serum 25(OH)D levels than non-supplementing controls (median 38 nmol/L vs 44 nmol/L). Participants engaged well with remote sampling.ConclusionsThe UK MS population have higher serum 25(OH)D than controls, mainly as a result of vitamin D supplementation. Remote sampling is a feasible way of carrying out large studies.</abstract><type>Journal Article</type><journal>PLOS ONE</journal><volume>15</volume><journalNumber>12</journalNumber><paginationStart>e0241459</paginationStart><paginationEnd/><publisher>Public Library of Science (PLoS)</publisher><placeOfPublication/><isbnPrint/><isbnElectronic/><issnPrint/><issnElectronic>1932-6203</issnElectronic><keywords/><publishedDay>30</publishedDay><publishedMonth>12</publishedMonth><publishedYear>2020</publishedYear><publishedDate>2020-12-30</publishedDate><doi>10.1371/journal.pone.0241459</doi><url/><notes/><college>COLLEGE NANME</college><department>Health Data Science</department><CollegeCode>COLLEGE CODE</CollegeCode><DepartmentCode>HDAT</DepartmentCode><institution>Swansea University</institution><apcterm/><funders>This study was funded by the UK MS Society. The work was performed on the Preventive Neurology Unit, which is funded by Barts Charity.</funders><projectreference/><lastEdited>2022-10-20T14:42:47.2162338</lastEdited><Created>2022-10-07T12:14:15.3327962</Created><path><level id="1">Faculty of Medicine, Health and Life Sciences</level><level id="2">Swansea University Medical School - Medicine</level></path><authors><author><firstname>Nicola</firstname><surname>Vickaryous</surname><order>1</order></author><author><firstname>Mark</firstname><surname>Jitlal</surname><order>2</order></author><author><firstname>Benjamin Meir</firstname><surname>Jacobs</surname><order>3</order></author><author><firstname>Rod</firstname><surname>Middleton</surname><orcid>0000-0002-2130-4420</orcid><order>4</order></author><author><firstname>Siddharthan</firstname><surname>Chandran</surname><order>5</order></author><author><firstname>Niall John James</firstname><surname>MacDougall</surname><order>6</order></author><author><firstname>Gavin</firstname><surname>Giovannoni</surname><order>7</order></author><author><firstname>Ruth</firstname><surname>Dobson</surname><orcid>0000-0002-2993-585x</orcid><order>8</order></author></authors><documents><document><filename>61487__25532__b70b019e04e14d238c7b3ca657b12be0.pdf</filename><originalFilename>61487_VoR.pdf</originalFilename><uploaded>2022-10-20T14:41:44.7071011</uploaded><type>Output</type><contentLength>950789</contentLength><contentType>application/pdf</contentType><version>Version of Record</version><cronfaStatus>true</cronfaStatus><documentNotes>&#xA9; 2020 Vickaryous et al. This is an open access article distributed under the terms of the Creative Commons Attribution License</documentNotes><copyrightCorrect>true</copyrightCorrect><language>eng</language><licence>http://creativecommons.org/licenses/by/4.0/</licence></document></documents><OutputDurs/></rfc1807>
spelling 2022-10-20T14:42:47.2162338 v2 61487 2022-10-07 Remote testing of vitamin D levels across the UK MS population—A case control study 005518f819ef1a2a13fdf438529bdfcd 0000-0002-2130-4420 Rod Middleton Rod Middleton true false 2022-10-07 HDAT ObjectiveThe association between vitamin D deficiency and multiple sclerosis (MS) is well described. We set out to use remote sampling to ascertain vitamin D status and vitamin D supplementation in a cross-sectional study of people with MS across the UK.MethodsPeople with MS and matched controls were recruited from across the UK. 1768 people with MS enrolled in the study; remote sampling kits were distributed to a subgroup. Dried blood spots (DBS) were used to assess serum 25(OH)D in people with MS and controls.Results1768 MS participants completed the questionnaire; 388 MS participants and 309 controls provided biological samples. Serum 25(OH)D was higher in MS than controls (median 71nmol/L vs 49nmol/L). A higher proportion of MS participants than controls supplemented (72% vs 26%, p<0.001); people with MS supplemented at higher vD doses than controls (median 1600 vs 600 IU/day, p<0.001). People with MS who did not supplement had lower serum 25(OH)D levels than non-supplementing controls (median 38 nmol/L vs 44 nmol/L). Participants engaged well with remote sampling.ConclusionsThe UK MS population have higher serum 25(OH)D than controls, mainly as a result of vitamin D supplementation. Remote sampling is a feasible way of carrying out large studies. Journal Article PLOS ONE 15 12 e0241459 Public Library of Science (PLoS) 1932-6203 30 12 2020 2020-12-30 10.1371/journal.pone.0241459 COLLEGE NANME Health Data Science COLLEGE CODE HDAT Swansea University This study was funded by the UK MS Society. The work was performed on the Preventive Neurology Unit, which is funded by Barts Charity. 2022-10-20T14:42:47.2162338 2022-10-07T12:14:15.3327962 Faculty of Medicine, Health and Life Sciences Swansea University Medical School - Medicine Nicola Vickaryous 1 Mark Jitlal 2 Benjamin Meir Jacobs 3 Rod Middleton 0000-0002-2130-4420 4 Siddharthan Chandran 5 Niall John James MacDougall 6 Gavin Giovannoni 7 Ruth Dobson 0000-0002-2993-585x 8 61487__25532__b70b019e04e14d238c7b3ca657b12be0.pdf 61487_VoR.pdf 2022-10-20T14:41:44.7071011 Output 950789 application/pdf Version of Record true © 2020 Vickaryous et al. This is an open access article distributed under the terms of the Creative Commons Attribution License true eng http://creativecommons.org/licenses/by/4.0/
title Remote testing of vitamin D levels across the UK MS population—A case control study
spellingShingle Remote testing of vitamin D levels across the UK MS population—A case control study
Rod Middleton
title_short Remote testing of vitamin D levels across the UK MS population—A case control study
title_full Remote testing of vitamin D levels across the UK MS population—A case control study
title_fullStr Remote testing of vitamin D levels across the UK MS population—A case control study
title_full_unstemmed Remote testing of vitamin D levels across the UK MS population—A case control study
title_sort Remote testing of vitamin D levels across the UK MS population—A case control study
author_id_str_mv 005518f819ef1a2a13fdf438529bdfcd
author_id_fullname_str_mv 005518f819ef1a2a13fdf438529bdfcd_***_Rod Middleton
author Rod Middleton
author2 Nicola Vickaryous
Mark Jitlal
Benjamin Meir Jacobs
Rod Middleton
Siddharthan Chandran
Niall John James MacDougall
Gavin Giovannoni
Ruth Dobson
format Journal article
container_title PLOS ONE
container_volume 15
container_issue 12
container_start_page e0241459
publishDate 2020
institution Swansea University
issn 1932-6203
doi_str_mv 10.1371/journal.pone.0241459
publisher Public Library of Science (PLoS)
college_str Faculty of Medicine, Health and Life Sciences
hierarchytype
hierarchy_top_id facultyofmedicinehealthandlifesciences
hierarchy_top_title Faculty of Medicine, Health and Life Sciences
hierarchy_parent_id facultyofmedicinehealthandlifesciences
hierarchy_parent_title Faculty of Medicine, Health and Life Sciences
department_str Swansea University Medical School - Medicine{{{_:::_}}}Faculty of Medicine, Health and Life Sciences{{{_:::_}}}Swansea University Medical School - Medicine
document_store_str 1
active_str 0
description ObjectiveThe association between vitamin D deficiency and multiple sclerosis (MS) is well described. We set out to use remote sampling to ascertain vitamin D status and vitamin D supplementation in a cross-sectional study of people with MS across the UK.MethodsPeople with MS and matched controls were recruited from across the UK. 1768 people with MS enrolled in the study; remote sampling kits were distributed to a subgroup. Dried blood spots (DBS) were used to assess serum 25(OH)D in people with MS and controls.Results1768 MS participants completed the questionnaire; 388 MS participants and 309 controls provided biological samples. Serum 25(OH)D was higher in MS than controls (median 71nmol/L vs 49nmol/L). A higher proportion of MS participants than controls supplemented (72% vs 26%, p<0.001); people with MS supplemented at higher vD doses than controls (median 1600 vs 600 IU/day, p<0.001). People with MS who did not supplement had lower serum 25(OH)D levels than non-supplementing controls (median 38 nmol/L vs 44 nmol/L). Participants engaged well with remote sampling.ConclusionsThe UK MS population have higher serum 25(OH)D than controls, mainly as a result of vitamin D supplementation. Remote sampling is a feasible way of carrying out large studies.
published_date 2020-12-30T04:20:20Z
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