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Remote testing of vitamin D levels across the UK MS population—A case control study
PLOS ONE, Volume: 15, Issue: 12, Start page: e0241459
Swansea University Author: Rod Middleton
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© 2020 Vickaryous et al. This is an open access article distributed under the terms of the Creative Commons Attribution LicenseDownload (928.5KB)
DOI (Published version): 10.1371/journal.pone.0241459
ObjectiveThe association between vitamin D deficiency and multiple sclerosis (MS) is well described. We set out to use remote sampling to ascertain vitamin D status and vitamin D supplementation in a cross-sectional study of people with MS across the UK.MethodsPeople with MS and matched controls wer...
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ObjectiveThe association between vitamin D deficiency and multiple sclerosis (MS) is well described. We set out to use remote sampling to ascertain vitamin D status and vitamin D supplementation in a cross-sectional study of people with MS across the UK.MethodsPeople with MS and matched controls were recruited from across the UK. 1768 people with MS enrolled in the study; remote sampling kits were distributed to a subgroup. Dried blood spots (DBS) were used to assess serum 25(OH)D in people with MS and controls.Results1768 MS participants completed the questionnaire; 388 MS participants and 309 controls provided biological samples. Serum 25(OH)D was higher in MS than controls (median 71nmol/L vs 49nmol/L). A higher proportion of MS participants than controls supplemented (72% vs 26%, p<0.001); people with MS supplemented at higher vD doses than controls (median 1600 vs 600 IU/day, p<0.001). People with MS who did not supplement had lower serum 25(OH)D levels than non-supplementing controls (median 38 nmol/L vs 44 nmol/L). Participants engaged well with remote sampling.ConclusionsThe UK MS population have higher serum 25(OH)D than controls, mainly as a result of vitamin D supplementation. Remote sampling is a feasible way of carrying out large studies.
Faculty of Medicine, Health and Life Sciences
This study was funded by the UK MS Society. The work was performed on the Preventive Neurology Unit, which is funded by Barts Charity.