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The polyphenol epigallocatechin gallate lowers circulating catecholamine concentrations and alters lipid metabolism during graded exercise in man: a randomized cross-over study
European Journal of Nutrition, Volume: 62, Issue: 3, Pages: 1517 - 1526
Swansea University Authors:
Rachel Churm , Gareth Dunseath
, Sarah Prior
, Richard Bracken
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DOI (Published version): 10.1007/s00394-023-03092-1
Abstract
Purpose: Physical exercise is shown to mitigate catecholamine metabolites; however, it is unknown if exercise-induced increases in sympatho-adrenal activity or catecholamine metabolites are influenced by ingestion of specific catechins found within green tea. This study explored the impact of epigal...
Published in: | European Journal of Nutrition |
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ISSN: | 1436-6207 1436-6215 |
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Springer Science and Business Media LLC
2023
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URI: | https://cronfa.swan.ac.uk/Record/cronfa62385 |
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<?xml version="1.0" encoding="utf-8"?><rfc1807 xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance" xmlns:xsd="http://www.w3.org/2001/XMLSchema"><bib-version>v2</bib-version><id>62385</id><entry>2023-01-20</entry><title>The polyphenol epigallocatechin gallate lowers circulating catecholamine concentrations and alters lipid metabolism during graded exercise in man: a randomized cross-over study</title><swanseaauthors><author><sid>c6cd8267ff0b13f2ea333bbfefdae144</sid><ORCID>0000-0001-9855-6282</ORCID><firstname>Rachel</firstname><surname>Churm</surname><name>Rachel Churm</name><active>true</active><ethesisStudent>false</ethesisStudent></author><author><sid>fccbba9edcaee08a839a3c5cff8cbe19</sid><ORCID>0000-0001-6022-862X</ORCID><firstname>Gareth</firstname><surname>Dunseath</surname><name>Gareth Dunseath</name><active>true</active><ethesisStudent>false</ethesisStudent></author><author><sid>cdda101035997acfaa6fdf17097f52b2</sid><ORCID>0000-0001-8703-8092</ORCID><firstname>Sarah</firstname><surname>Prior</surname><name>Sarah Prior</name><active>true</active><ethesisStudent>false</ethesisStudent></author><author><sid>f5da81cd18adfdedb2ccb845bddc12f7</sid><ORCID>0000-0002-6986-6449</ORCID><firstname>Richard</firstname><surname>Bracken</surname><name>Richard Bracken</name><active>true</active><ethesisStudent>false</ethesisStudent></author></swanseaauthors><date>2023-01-20</date><deptcode>STSC</deptcode><abstract>Purpose: Physical exercise is shown to mitigate catecholamine metabolites; however, it is unknown if exercise-induced increases in sympatho-adrenal activity or catecholamine metabolites are influenced by ingestion of specific catechins found within green tea. This study explored the impact of epigallocatechin gallate (EGCG) ingestion on catecholamine metabolism during graded cycle exercise in humans. Methods: Eight males (22.4 ± 3.3 years, BMI:25.7 ± 2.4 kg.m2) performed a randomised, placebo-controlled, single-blind, cross-over trial after consumption (1450 mg) of either EGCG or placebo (PLAC) and performed graded cycling to volitional exhaustion. Venous bloods were taken at rest, 2 h post-ingestion and after every 3-min stage. Blood variables were analysed for catecholamines, catecholamine metanephrines and metabolic variables at rest, 2 h post-ingestion (POST-ING), peak rate of lipid oxidation (FATpeak), lactate threshold (LT) and peak rate of oxygen consumption (VO2peak). Data were analysed using SPSS (Version 26). Results: Resting catecholamine and metanephrines were similar between trials. Plasma adrenaline (AD) was lower in ECGC treatment group between trials at FATpeak (P < 0.05), LT (P < 0.001) and VO2peak (P < 0.01). Noradrenaline (NA) was lower under EGCG at POST (P < 0.05), FATpeak (P < 0.05), LT (P < 0.01) and VO2peak (P < 0.05) compared to PLAC. Metanephrines, glucose and lactate increased similarly with exercise intensity in both trials. Lipid oxidation rate was 32% lower in EGCG at FATpeak (EGCG 0.33 ± 0.14 vs. PLAC 0.49 ± 0.11 g.min−1, P < 0.05). Cycle time to exhaustion was similar (NS). Conclusion: Acute EGCG supplementation reduced circulating catecholamines but not; metanephrine, glucose or lactates, response to graded exercise. Lower circulating catecholamines may explain a lower lipid oxidation rate.</abstract><type>Journal Article</type><journal>European Journal of Nutrition</journal><volume>62</volume><journalNumber>3</journalNumber><paginationStart>1517</paginationStart><paginationEnd>1526</paginationEnd><publisher>Springer Science and Business Media LLC</publisher><placeOfPublication/><isbnPrint/><isbnElectronic/><issnPrint>1436-6207</issnPrint><issnElectronic>1436-6215</issnElectronic><keywords>Epigallocatechin gallate, Catecholamines, Substrate metabolism, Graded exercise</keywords><publishedDay>1</publishedDay><publishedMonth>4</publishedMonth><publishedYear>2023</publishedYear><publishedDate>2023-04-01</publishedDate><doi>10.1007/s00394-023-03092-1</doi><url>http://dx.doi.org/10.1007/s00394-023-03092-1</url><notes/><college>COLLEGE NANME</college><department>Sport and Exercise Sciences</department><CollegeCode>COLLEGE CODE</CollegeCode><DepartmentCode>STSC</DepartmentCode><institution>Swansea University</institution><apcterm>SU Library paid the OA fee (TA Institutional Deal)</apcterm><funders>This research did not receive any specific grant from funding agencies in the public, commercial, or not-for-profit sectors.</funders><projectreference/><lastEdited>2023-06-20T16:22:16.8718593</lastEdited><Created>2023-01-20T11:57:33.4121990</Created><path><level id="1">Faculty of Science and Engineering</level><level id="2">School of Engineering and Applied Sciences - Sport and Exercise Sciences</level></path><authors><author><firstname>Rachel</firstname><surname>Churm</surname><orcid>0000-0001-9855-6282</orcid><order>1</order></author><author><firstname>Liam M.</firstname><surname>Williams</surname><order>2</order></author><author><firstname>Gareth</firstname><surname>Dunseath</surname><order>3</order></author><author><firstname>Sarah L.</firstname><surname>Prior</surname><order>4</order></author><author><firstname>Richard M.</firstname><surname>Bracken</surname><order>5</order></author><author><firstname>Gareth</firstname><surname>Dunseath</surname><orcid>0000-0001-6022-862X</orcid><order>6</order></author><author><firstname>Sarah</firstname><surname>Prior</surname><orcid>0000-0001-8703-8092</orcid><order>7</order></author><author><firstname>Richard</firstname><surname>Bracken</surname><orcid>0000-0002-6986-6449</orcid><order>8</order></author></authors><documents><document><filename>62385__27898__3dc279e334ba4129bbcaef519c231d83.pdf</filename><originalFilename>62385.VOR.pdf</originalFilename><uploaded>2023-06-20T16:18:56.3313011</uploaded><type>Output</type><contentLength>698775</contentLength><contentType>application/pdf</contentType><version>Version of Record</version><cronfaStatus>true</cronfaStatus><documentNotes>© The Author(s) 2023. Distributed under the terms of a Creative Commons Attribution 4.0 License (CC BY 4.0).</documentNotes><copyrightCorrect>true</copyrightCorrect><language>eng</language><licence>https://creativecommons.org/licenses/by/4.0/</licence></document></documents><OutputDurs/></rfc1807> |
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v2 62385 2023-01-20 The polyphenol epigallocatechin gallate lowers circulating catecholamine concentrations and alters lipid metabolism during graded exercise in man: a randomized cross-over study c6cd8267ff0b13f2ea333bbfefdae144 0000-0001-9855-6282 Rachel Churm Rachel Churm true false fccbba9edcaee08a839a3c5cff8cbe19 0000-0001-6022-862X Gareth Dunseath Gareth Dunseath true false cdda101035997acfaa6fdf17097f52b2 0000-0001-8703-8092 Sarah Prior Sarah Prior true false f5da81cd18adfdedb2ccb845bddc12f7 0000-0002-6986-6449 Richard Bracken Richard Bracken true false 2023-01-20 STSC Purpose: Physical exercise is shown to mitigate catecholamine metabolites; however, it is unknown if exercise-induced increases in sympatho-adrenal activity or catecholamine metabolites are influenced by ingestion of specific catechins found within green tea. This study explored the impact of epigallocatechin gallate (EGCG) ingestion on catecholamine metabolism during graded cycle exercise in humans. Methods: Eight males (22.4 ± 3.3 years, BMI:25.7 ± 2.4 kg.m2) performed a randomised, placebo-controlled, single-blind, cross-over trial after consumption (1450 mg) of either EGCG or placebo (PLAC) and performed graded cycling to volitional exhaustion. Venous bloods were taken at rest, 2 h post-ingestion and after every 3-min stage. Blood variables were analysed for catecholamines, catecholamine metanephrines and metabolic variables at rest, 2 h post-ingestion (POST-ING), peak rate of lipid oxidation (FATpeak), lactate threshold (LT) and peak rate of oxygen consumption (VO2peak). Data were analysed using SPSS (Version 26). Results: Resting catecholamine and metanephrines were similar between trials. Plasma adrenaline (AD) was lower in ECGC treatment group between trials at FATpeak (P < 0.05), LT (P < 0.001) and VO2peak (P < 0.01). Noradrenaline (NA) was lower under EGCG at POST (P < 0.05), FATpeak (P < 0.05), LT (P < 0.01) and VO2peak (P < 0.05) compared to PLAC. Metanephrines, glucose and lactate increased similarly with exercise intensity in both trials. Lipid oxidation rate was 32% lower in EGCG at FATpeak (EGCG 0.33 ± 0.14 vs. PLAC 0.49 ± 0.11 g.min−1, P < 0.05). Cycle time to exhaustion was similar (NS). Conclusion: Acute EGCG supplementation reduced circulating catecholamines but not; metanephrine, glucose or lactates, response to graded exercise. Lower circulating catecholamines may explain a lower lipid oxidation rate. Journal Article European Journal of Nutrition 62 3 1517 1526 Springer Science and Business Media LLC 1436-6207 1436-6215 Epigallocatechin gallate, Catecholamines, Substrate metabolism, Graded exercise 1 4 2023 2023-04-01 10.1007/s00394-023-03092-1 http://dx.doi.org/10.1007/s00394-023-03092-1 COLLEGE NANME Sport and Exercise Sciences COLLEGE CODE STSC Swansea University SU Library paid the OA fee (TA Institutional Deal) This research did not receive any specific grant from funding agencies in the public, commercial, or not-for-profit sectors. 2023-06-20T16:22:16.8718593 2023-01-20T11:57:33.4121990 Faculty of Science and Engineering School of Engineering and Applied Sciences - Sport and Exercise Sciences Rachel Churm 0000-0001-9855-6282 1 Liam M. Williams 2 Gareth Dunseath 3 Sarah L. Prior 4 Richard M. Bracken 5 Gareth Dunseath 0000-0001-6022-862X 6 Sarah Prior 0000-0001-8703-8092 7 Richard Bracken 0000-0002-6986-6449 8 62385__27898__3dc279e334ba4129bbcaef519c231d83.pdf 62385.VOR.pdf 2023-06-20T16:18:56.3313011 Output 698775 application/pdf Version of Record true © The Author(s) 2023. Distributed under the terms of a Creative Commons Attribution 4.0 License (CC BY 4.0). true eng https://creativecommons.org/licenses/by/4.0/ |
title |
The polyphenol epigallocatechin gallate lowers circulating catecholamine concentrations and alters lipid metabolism during graded exercise in man: a randomized cross-over study |
spellingShingle |
The polyphenol epigallocatechin gallate lowers circulating catecholamine concentrations and alters lipid metabolism during graded exercise in man: a randomized cross-over study Rachel Churm Gareth Dunseath Sarah Prior Richard Bracken |
title_short |
The polyphenol epigallocatechin gallate lowers circulating catecholamine concentrations and alters lipid metabolism during graded exercise in man: a randomized cross-over study |
title_full |
The polyphenol epigallocatechin gallate lowers circulating catecholamine concentrations and alters lipid metabolism during graded exercise in man: a randomized cross-over study |
title_fullStr |
The polyphenol epigallocatechin gallate lowers circulating catecholamine concentrations and alters lipid metabolism during graded exercise in man: a randomized cross-over study |
title_full_unstemmed |
The polyphenol epigallocatechin gallate lowers circulating catecholamine concentrations and alters lipid metabolism during graded exercise in man: a randomized cross-over study |
title_sort |
The polyphenol epigallocatechin gallate lowers circulating catecholamine concentrations and alters lipid metabolism during graded exercise in man: a randomized cross-over study |
author_id_str_mv |
c6cd8267ff0b13f2ea333bbfefdae144 fccbba9edcaee08a839a3c5cff8cbe19 cdda101035997acfaa6fdf17097f52b2 f5da81cd18adfdedb2ccb845bddc12f7 |
author_id_fullname_str_mv |
c6cd8267ff0b13f2ea333bbfefdae144_***_Rachel Churm fccbba9edcaee08a839a3c5cff8cbe19_***_Gareth Dunseath cdda101035997acfaa6fdf17097f52b2_***_Sarah Prior f5da81cd18adfdedb2ccb845bddc12f7_***_Richard Bracken |
author |
Rachel Churm Gareth Dunseath Sarah Prior Richard Bracken |
author2 |
Rachel Churm Liam M. Williams Gareth Dunseath Sarah L. Prior Richard M. Bracken Gareth Dunseath Sarah Prior Richard Bracken |
format |
Journal article |
container_title |
European Journal of Nutrition |
container_volume |
62 |
container_issue |
3 |
container_start_page |
1517 |
publishDate |
2023 |
institution |
Swansea University |
issn |
1436-6207 1436-6215 |
doi_str_mv |
10.1007/s00394-023-03092-1 |
publisher |
Springer Science and Business Media LLC |
college_str |
Faculty of Science and Engineering |
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|
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facultyofscienceandengineering |
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Faculty of Science and Engineering |
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facultyofscienceandengineering |
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Faculty of Science and Engineering |
department_str |
School of Engineering and Applied Sciences - Sport and Exercise Sciences{{{_:::_}}}Faculty of Science and Engineering{{{_:::_}}}School of Engineering and Applied Sciences - Sport and Exercise Sciences |
url |
http://dx.doi.org/10.1007/s00394-023-03092-1 |
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0 |
description |
Purpose: Physical exercise is shown to mitigate catecholamine metabolites; however, it is unknown if exercise-induced increases in sympatho-adrenal activity or catecholamine metabolites are influenced by ingestion of specific catechins found within green tea. This study explored the impact of epigallocatechin gallate (EGCG) ingestion on catecholamine metabolism during graded cycle exercise in humans. Methods: Eight males (22.4 ± 3.3 years, BMI:25.7 ± 2.4 kg.m2) performed a randomised, placebo-controlled, single-blind, cross-over trial after consumption (1450 mg) of either EGCG or placebo (PLAC) and performed graded cycling to volitional exhaustion. Venous bloods were taken at rest, 2 h post-ingestion and after every 3-min stage. Blood variables were analysed for catecholamines, catecholamine metanephrines and metabolic variables at rest, 2 h post-ingestion (POST-ING), peak rate of lipid oxidation (FATpeak), lactate threshold (LT) and peak rate of oxygen consumption (VO2peak). Data were analysed using SPSS (Version 26). Results: Resting catecholamine and metanephrines were similar between trials. Plasma adrenaline (AD) was lower in ECGC treatment group between trials at FATpeak (P < 0.05), LT (P < 0.001) and VO2peak (P < 0.01). Noradrenaline (NA) was lower under EGCG at POST (P < 0.05), FATpeak (P < 0.05), LT (P < 0.01) and VO2peak (P < 0.05) compared to PLAC. Metanephrines, glucose and lactate increased similarly with exercise intensity in both trials. Lipid oxidation rate was 32% lower in EGCG at FATpeak (EGCG 0.33 ± 0.14 vs. PLAC 0.49 ± 0.11 g.min−1, P < 0.05). Cycle time to exhaustion was similar (NS). Conclusion: Acute EGCG supplementation reduced circulating catecholamines but not; metanephrine, glucose or lactates, response to graded exercise. Lower circulating catecholamines may explain a lower lipid oxidation rate. |
published_date |
2023-04-01T16:22:14Z |
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1769235582158897152 |
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11.021648 |