Journal article 113 views
Expanding the genome information on<i>Bacillales</i>for biosynthetic gene cluster discovery
Lijie Song,
Lasse Johan Dyrbye Nielsen,
Xinming Xu 
,
Omkar Satyavan Mohite ,
Matin Nuhamunada ,
Zhihui Xu,
Rob Murphy,
Kasun Bodawatta ,
Michael Poulsen ,
Mohamed Hatha Abdulla ,
Eva C. Sonnenschein ,
Tilmann Weber ,
Ákos T. Kovács
,
Omkar Satyavan Mohite ,
Matin Nuhamunada ,
Zhihui Xu,
Rob Murphy,
Kasun Bodawatta ,
Michael Poulsen ,
Mohamed Hatha Abdulla ,
Eva C. Sonnenschein ,
Tilmann Weber ,
Ákos T. Kovács
bioRxiv
Swansea University Author:
Eva C. Sonnenschein
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DOI (Published version): 10.1101/2024.04.24.590912
Abstract
This study showcases 121 new genomes of spore-forming Bacillales from strains collected globally from a variety of habitats, assembled using Oxford Nanopore long-read and MGI short-read sequences. Bacilli are renowned for their capacity to produce diverse secondary metabolites with use in agricultur...
| Published in: | bioRxiv |
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| Published: |
Cold Spring Harbor Laboratory
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| URI: | https://cronfa.swan.ac.uk/Record/cronfa66577 |
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| Abstract: |
This study showcases 121 new genomes of spore-forming Bacillales from strains collected globally from a variety of habitats, assembled using Oxford Nanopore long-read and MGI short-read sequences. Bacilli are renowned for their capacity to produce diverse secondary metabolites with use in agriculture, biotechnology, and medicine. These secondary metabolites are encoded within biosynthetic gene clusters (smBGCs). smBGCs have significant research interest due to their potential for the discovery of new bioactivate compounds. Our dataset includes 62 complete genomes, 2 at chromosome level, and 57 at contig level, covering a genomic size range from 3.50 Mb to 7.15 Mb. Phylotaxonomic analysis revealed that these genomes span 16 genera, with 69 of them belonging to Bacillus. A total of 1,176 predicted BGCs were identified by in silico genome mining. We anticipate that the open-access data presented here will expand the reported genomic information of spore-forming Bacillales and facilitate a deeper understanding of the genetic basis of Bacillales’ potential for secondary metabolite production. |
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| Item Description: |
Preprint article before certification by peer review. |
| College: |
Faculty of Science and Engineering |