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Expanding the genome information on Bacillales for biosynthetic gene cluster discovery

Lijie Song, Lasse Johan Dyrbye Nielsen, Xinming Xu, Omkar Satyavan Mohite, Matin Nuhamunada Orcid Logo, Zhihui Xu, Rob Murphy, Kasun Bodawatta, Michael Poulsen Orcid Logo, Mohamed Hatha Abdulla, Eva C. Sonnenschein Orcid Logo, Tilmann Weber Orcid Logo, Ákos T. Kovács Orcid Logo

Scientific Data, Volume: 11, Start page: 1267

Swansea University Author: Eva C. Sonnenschein Orcid Logo

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DOI (Published version): 10.1038/s41597-024-04118-x

Abstract

This study showcases 121 new genomes of spore-forming Bacillales from strains collected globally from a variety of habitats, assembled using Oxford Nanopore long-read and MGI short-read sequences. Bacilli are renowned for their capacity to produce diverse secondary metabolites with use in agricultur...

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Published in: Scientific Data
ISSN: 2052-4463
Published: Springer Nature 2024
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URI: https://cronfa.swan.ac.uk/Record/cronfa66577
first_indexed 2024-07-24T13:30:26Z
last_indexed 2024-12-05T19:43:08Z
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spelling 2024-12-05T12:20:29.6148897 v2 66577 2024-06-03 Expanding the genome information on Bacillales for biosynthetic gene cluster discovery f6a4027578a15ea3e6453a54b849c686 0000-0001-6959-5100 Eva C. Sonnenschein Eva C. Sonnenschein true false 2024-06-03 BGPS This study showcases 121 new genomes of spore-forming Bacillales from strains collected globally from a variety of habitats, assembled using Oxford Nanopore long-read and MGI short-read sequences. Bacilli are renowned for their capacity to produce diverse secondary metabolites with use in agriculture, biotechnology, and medicine. These secondary metabolites are encoded within biosynthetic gene clusters (smBGCs). smBGCs have significant research interest due to their potential as sources of new bioactivate compounds. Our dataset includes 62 complete genomes, 2 at chromosome level, and 57 at contig level, covering a genomic size range from 3.50 Mb to 7.15 Mb. Phylotaxonomic analysis revealed that these genomes span 16 genera, with 69 of them belonging to Bacillus. A total of 1,176 predicted BGCs were identified by in silico genome mining. We anticipate that the open-access data presented here will expand the reported genomic information of spore-forming Bacillales and facilitate a deeper understanding of the genetic basis of Bacillales’ potential for secondary metabolite production. Journal Article Scientific Data 11 1267 Springer Nature 2052-4463 21 11 2024 2024-11-21 10.1038/s41597-024-04118-x Data Descriptor COLLEGE NANME Biosciences Geography and Physics School COLLEGE CODE BGPS Swansea University Another institution paid the OA fee This project was supported by the Danish National Research Foundation (DNRF137) for the Center for Microbial Secondary Metabolites, and Novo Nordisk Foundation within the INTERACT project of the Collaborative Crop Resiliency Program (NNF19SA0059360). TW acknowledges funding from the Novo Nordisk Foundation (NNF20CC0035580). 2024-12-05T12:20:29.6148897 2024-06-03T14:14:13.4085212 Faculty of Science and Engineering School of Biosciences, Geography and Physics - Biosciences Lijie Song 1 Lasse Johan Dyrbye Nielsen 2 Xinming Xu 3 Omkar Satyavan Mohite 4 Matin Nuhamunada 0000-0003-3177-8299 5 Zhihui Xu 6 Rob Murphy 7 Kasun Bodawatta 8 Michael Poulsen 0000-0002-2839-1715 9 Mohamed Hatha Abdulla 10 Eva C. Sonnenschein 0000-0001-6959-5100 11 Tilmann Weber 0000-0002-8260-5120 12 Ákos T. Kovács 0000-0002-4465-1636 13
title Expanding the genome information on Bacillales for biosynthetic gene cluster discovery
spellingShingle Expanding the genome information on Bacillales for biosynthetic gene cluster discovery
Eva C. Sonnenschein
title_short Expanding the genome information on Bacillales for biosynthetic gene cluster discovery
title_full Expanding the genome information on Bacillales for biosynthetic gene cluster discovery
title_fullStr Expanding the genome information on Bacillales for biosynthetic gene cluster discovery
title_full_unstemmed Expanding the genome information on Bacillales for biosynthetic gene cluster discovery
title_sort Expanding the genome information on Bacillales for biosynthetic gene cluster discovery
author_id_str_mv f6a4027578a15ea3e6453a54b849c686
author_id_fullname_str_mv f6a4027578a15ea3e6453a54b849c686_***_Eva C. Sonnenschein
author Eva C. Sonnenschein
author2 Lijie Song
Lasse Johan Dyrbye Nielsen
Xinming Xu
Omkar Satyavan Mohite
Matin Nuhamunada
Zhihui Xu
Rob Murphy
Kasun Bodawatta
Michael Poulsen
Mohamed Hatha Abdulla
Eva C. Sonnenschein
Tilmann Weber
Ákos T. Kovács
format Journal article
container_title Scientific Data
container_volume 11
container_start_page 1267
publishDate 2024
institution Swansea University
issn 2052-4463
doi_str_mv 10.1038/s41597-024-04118-x
publisher Springer Nature
college_str Faculty of Science and Engineering
hierarchytype
hierarchy_top_id facultyofscienceandengineering
hierarchy_top_title Faculty of Science and Engineering
hierarchy_parent_id facultyofscienceandengineering
hierarchy_parent_title Faculty of Science and Engineering
department_str School of Biosciences, Geography and Physics - Biosciences{{{_:::_}}}Faculty of Science and Engineering{{{_:::_}}}School of Biosciences, Geography and Physics - Biosciences
document_store_str 0
active_str 0
description This study showcases 121 new genomes of spore-forming Bacillales from strains collected globally from a variety of habitats, assembled using Oxford Nanopore long-read and MGI short-read sequences. Bacilli are renowned for their capacity to produce diverse secondary metabolites with use in agriculture, biotechnology, and medicine. These secondary metabolites are encoded within biosynthetic gene clusters (smBGCs). smBGCs have significant research interest due to their potential as sources of new bioactivate compounds. Our dataset includes 62 complete genomes, 2 at chromosome level, and 57 at contig level, covering a genomic size range from 3.50 Mb to 7.15 Mb. Phylotaxonomic analysis revealed that these genomes span 16 genera, with 69 of them belonging to Bacillus. A total of 1,176 predicted BGCs were identified by in silico genome mining. We anticipate that the open-access data presented here will expand the reported genomic information of spore-forming Bacillales and facilitate a deeper understanding of the genetic basis of Bacillales’ potential for secondary metabolite production.
published_date 2024-11-21T08:30:37Z
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score 11.085372

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