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Expanding the genome information on<i>Bacillales</i>for biosynthetic gene cluster discovery

Lijie Song, Lasse Johan Dyrbye Nielsen, Xinming Xu Orcid Logo, Omkar Satyavan Mohite Orcid Logo, Matin Nuhamunada Orcid Logo, Zhihui Xu, Rob Murphy, Kasun Bodawatta Orcid Logo, Michael Poulsen Orcid Logo, Mohamed Hatha Abdulla Orcid Logo, Eva C. Sonnenschein Orcid Logo, Tilmann Weber Orcid Logo, Ákos T. Kovács Orcid Logo

bioRxiv

Swansea University Author: Eva C. Sonnenschein Orcid Logo

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DOI (Published version): 10.1101/2024.04.24.590912

Abstract

This study showcases 121 new genomes of spore-forming Bacillales from strains collected globally from a variety of habitats, assembled using Oxford Nanopore long-read and MGI short-read sequences. Bacilli are renowned for their capacity to produce diverse secondary metabolites with use in agricultur...

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Published in: bioRxiv
Published: Cold Spring Harbor Laboratory
URI: https://cronfa.swan.ac.uk/Record/cronfa66577
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spelling v2 66577 2024-06-03 Expanding the genome information on<i>Bacillales</i>for biosynthetic gene cluster discovery f6a4027578a15ea3e6453a54b849c686 0000-0001-6959-5100 Eva C. Sonnenschein Eva C. Sonnenschein true false 2024-06-03 BGPS This study showcases 121 new genomes of spore-forming Bacillales from strains collected globally from a variety of habitats, assembled using Oxford Nanopore long-read and MGI short-read sequences. Bacilli are renowned for their capacity to produce diverse secondary metabolites with use in agriculture, biotechnology, and medicine. These secondary metabolites are encoded within biosynthetic gene clusters (smBGCs). smBGCs have significant research interest due to their potential for the discovery of new bioactivate compounds. Our dataset includes 62 complete genomes, 2 at chromosome level, and 57 at contig level, covering a genomic size range from 3.50 Mb to 7.15 Mb. Phylotaxonomic analysis revealed that these genomes span 16 genera, with 69 of them belonging to Bacillus. A total of 1,176 predicted BGCs were identified by in silico genome mining. We anticipate that the open-access data presented here will expand the reported genomic information of spore-forming Bacillales and facilitate a deeper understanding of the genetic basis of Bacillales’ potential for secondary metabolite production. Journal Article bioRxiv Cold Spring Harbor Laboratory 0 0 0 0001-01-01 10.1101/2024.04.24.590912 Preprint article before certification by peer review. COLLEGE NANME Biosciences Geography and Physics School COLLEGE CODE BGPS Swansea University 2024-07-24T14:30:27.3995025 2024-06-03T14:14:13.4085212 Faculty of Science and Engineering School of Biosciences, Geography and Physics - Biosciences Lijie Song 1 Lasse Johan Dyrbye Nielsen 2 Xinming Xu 0000-0002-3203-4526 3 Omkar Satyavan Mohite 0000-0002-3240-1656 4 Matin Nuhamunada 0000-0003-3177-8299 5 Zhihui Xu 6 Rob Murphy 7 Kasun Bodawatta 0000-0002-6095-9059 8 Michael Poulsen 0000-0002-2839-1715 9 Mohamed Hatha Abdulla 0000-0003-0136-2911 10 Eva C. Sonnenschein 0000-0001-6959-5100 11 Tilmann Weber 0000-0002-8260-5120 12 Ákos T. Kovács 0000-0002-4465-1636 13
title Expanding the genome information on<i>Bacillales</i>for biosynthetic gene cluster discovery
spellingShingle Expanding the genome information on<i>Bacillales</i>for biosynthetic gene cluster discovery
Eva C. Sonnenschein
title_short Expanding the genome information on<i>Bacillales</i>for biosynthetic gene cluster discovery
title_full Expanding the genome information on<i>Bacillales</i>for biosynthetic gene cluster discovery
title_fullStr Expanding the genome information on<i>Bacillales</i>for biosynthetic gene cluster discovery
title_full_unstemmed Expanding the genome information on<i>Bacillales</i>for biosynthetic gene cluster discovery
title_sort Expanding the genome information on<i>Bacillales</i>for biosynthetic gene cluster discovery
author_id_str_mv f6a4027578a15ea3e6453a54b849c686
author_id_fullname_str_mv f6a4027578a15ea3e6453a54b849c686_***_Eva C. Sonnenschein
author Eva C. Sonnenschein
author2 Lijie Song
Lasse Johan Dyrbye Nielsen
Xinming Xu
Omkar Satyavan Mohite
Matin Nuhamunada
Zhihui Xu
Rob Murphy
Kasun Bodawatta
Michael Poulsen
Mohamed Hatha Abdulla
Eva C. Sonnenschein
Tilmann Weber
Ákos T. Kovács
format Journal article
container_title bioRxiv
institution Swansea University
doi_str_mv 10.1101/2024.04.24.590912
publisher Cold Spring Harbor Laboratory
college_str Faculty of Science and Engineering
hierarchytype
hierarchy_top_id facultyofscienceandengineering
hierarchy_top_title Faculty of Science and Engineering
hierarchy_parent_id facultyofscienceandengineering
hierarchy_parent_title Faculty of Science and Engineering
department_str School of Biosciences, Geography and Physics - Biosciences{{{_:::_}}}Faculty of Science and Engineering{{{_:::_}}}School of Biosciences, Geography and Physics - Biosciences
document_store_str 0
active_str 0
description This study showcases 121 new genomes of spore-forming Bacillales from strains collected globally from a variety of habitats, assembled using Oxford Nanopore long-read and MGI short-read sequences. Bacilli are renowned for their capacity to produce diverse secondary metabolites with use in agriculture, biotechnology, and medicine. These secondary metabolites are encoded within biosynthetic gene clusters (smBGCs). smBGCs have significant research interest due to their potential for the discovery of new bioactivate compounds. Our dataset includes 62 complete genomes, 2 at chromosome level, and 57 at contig level, covering a genomic size range from 3.50 Mb to 7.15 Mb. Phylotaxonomic analysis revealed that these genomes span 16 genera, with 69 of them belonging to Bacillus. A total of 1,176 predicted BGCs were identified by in silico genome mining. We anticipate that the open-access data presented here will expand the reported genomic information of spore-forming Bacillales and facilitate a deeper understanding of the genetic basis of Bacillales’ potential for secondary metabolite production.
published_date 0001-01-01T14:30:26Z
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score 11.028798

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