Journal article 3 views
The behavioural, toxicological, and biochemical effects of caffeine on Lumbriculus variegatus
,
Aidan Seeley
Environmental Toxicology and Pharmacology, Start page: 104975
Swansea University Authors:
Grace Labdon, Nia Davies, Sophie Reed , Aidan Seeley
Full text not available from this repository: check for access using links below.
DOI (Published version): 10.1016/j.etap.2026.104975
Abstract
Lumbriculus variegatus is increasingly used in environmental toxicology and pharmacology, yet the behavioural, toxicological and biochemical effects of caffeine in this species remain poorly defined. Here, we characterised caffeine’s effects on stimulated behaviours, locomotor activity, toxicity, an...
| Published in: | Environmental Toxicology and Pharmacology |
|---|---|
| ISSN: | 1382-6689 |
| Published: |
Elsevier BV
2026
|
| Online Access: |
Check full text
|
| URI: | https://cronfa.swan.ac.uk/Record/cronfa71493 |
| Abstract: |
Lumbriculus variegatus is increasingly used in environmental toxicology and pharmacology, yet the behavioural, toxicological and biochemical effects of caffeine in this species remain poorly defined. Here, we characterised caffeine’s effects on stimulated behaviours, locomotor activity, toxicity, and energy stores. Exposure to ≥5.0 mM caffeine for 10 minutes or ≥3.0 mM for 24 hours significantly reduced stimulated behaviours, with locomotor activity similarly suppressed at ≥5.0 mM (10 minutes) and ≥1.0 mM (24 hours) (p < .05, n = 8) with impairment persisting 24 hours after exposure to 10 mM (10 minutes) or 3.5 mM (24 hours). A 24-hour LC50 of 4.7 mM (95% CI: 4.60–4.70 mM) was observed, with significant lethality after seven days at 4.5 mM (p < .0001). These findings provide the first characterisation of caffeine’s behavioural and toxicological effects in L. variegatus and contribute to the environmental risk assessment of caffeine contamination in freshwater systems. |
|---|---|
| College: |
Faculty of Medicine, Health and Life Sciences |
| Start Page: |
104975 |